References

We’ve compiled all the resources we examined in preparing the information on this website, and want you to have access too. Unfortunately some of these resources are behind a pay-wall, but we’ve linked to open source options whenever possible.

Crippa, J. A., Zuardi, A. W., Martín-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., & Fusar-Poli, P. (2009). Cannabis and anxiety: A critical review of the evidence. Human Psychopharmacology, 24(7), 515-523. https://doi.org/10.1002/hup.1048

 

Darkovska-Serafimovska, M., Serafimovska, T., Arsova-Sarafinovska, Z., Stefanoski, S., Keskovski, Z., & Balkanov, T. (2018). Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases. Journal of Pain Research, 11, 837-842. https://doi.org/10.2147/JPR.S160556

 

Government of Canada. (2018, October 17). About cannabis. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/about.html

 

Grinspoon, P. (2020, September 24). Cannabidiol (cbd)-What we know and what we don’t. Harvard Health Publishing. https://www.health.harvard.edu/blog/cannabidiol-cbd-what-we-know-and-what-we-dont-2018082414476

 

Guimarães, F. S., Chiaretti, T. M., Graeff, F. G., and Zuardi, A. W. (1990). Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology, 100(4), 558–559. https://doi.org/10.1007/BF02244012

 

How cbd can be taken: 4 different delivery methods. (2020). Phytoextractum. https://www.phytoextractum.com/resources/how-cbd-can-be-taken-4-different-delivery-methods/

 

Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., Klosterkötter, J., Hellmich, M., & Koethe, D. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry, 2(3), e94-e94. https://doi.org/10.1038/tp.2012.15

 

Lowe, D. J. E., Sasiadek, J. D., Coles, A. S., & George, T. P. (2019). Cannabis and mental illness: A review. European Archives of Psychiatry and Clinical Neuroscience, 269(1), 107-120. https://doi.org/10.1007/s00406-018-0970-7

 

McGuire, P., Robson, P., Cubala, W. J., Vasile, D., Morrison, P. D., Barron, R., Taylor, A., & Wright, S. (2018). Cannabidiol (cbd) as an adjunctive therapy in schizophrenia: A multicenter randomized controlled trial. The American Journal of Psychiatry, 175(3), 225-231. https://doi.org/10.1176/appi.ajp.2017.17030325

 

Pearson, J., Martin, A., Horgan, K., Wittreich, J., Gertz, B., & Lindley, C. (2000). Vomiting-and nausea-specific quality of life in patients with acute and delayed chemotherapy-induced emesis. Quality of Life Research, 9(3), 296-296. https://www.jstor.org/stable/4036294

 

Rexaline, S. (2019, March 7). Cbd vs. thc: The science behind most popular cannabinoids. Benzinga. https://www.benzinga.com/markets/cannabis/19/03/13312269/cbd-vs-thc-the-science-behind-the-most-popular-cannabinoids?utm_sq=g0v89su8hc&utm_source=Twitter&utm_medium=social&utm_campaign=ParkAmerican&utm_content=NewsArticles

 

Shannon, S., & Opila-Lehman, J. (2016). Effectiveness of cannabidiol oil for pediatric anxiety and insomnia as part of posttraumatic stress disorder: A case report. Permanente Journal, 20(4), 16-005. https://doi.org/10.7812/TPP/16-005

 

Anthony J. C., Warner L. A., Kessler R. C. (1994). Comparative epidemiology of dependence on tobacco, alcohol, controlled substances, and inhalants: Basic findings from the national comorbidity survey. Experimental and Clinical Psychopharmacology, 2(3), 244–268. https://doi.org/10.1037/1064-1297.2.3.244

 

Arendt, M., Rosenberg, R., Foldager, L., Perto, G., & Munk-Jørgensen, P. (2005). Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: Follow-up study of 535 incident cases. British Journal of Psychiatry, 187(6), 510-515. https://doi.org/10.1192/bjp.187.6.510

 

Arkowitz, H., & Lilienfeld, S. (2021, March 1). Experts tell the truth about pot. Scientific American. https://www.scientificamerican.com/article/the-truth-about-pot/

 

Bab, I., Zimmer, A., & Melamed, E. (2009). Cannabinoids and the skeleton: From marijuana to reversal of bone loss. Annals of Medicine (Helsinki), 41(8), 560-567. https://doi.org/10.1080/07853890903121025

 

Canadian Centre on Substance Use and Addiction. (2019). 7 things about edible cannabis. https://www.ccsa.ca/sites/default/files/2019-06/CCSA-7-Things-About-Edible-Cannabis-2019-en.pdf

 

Corey-Bloom, J., Wolfson, T., Gamst, A., Jin, S., Marcotte, T. D., Bentley, H., & Gouaux, B. (2012). Smoked cannabis for spasticity in multiple sclerosis: A randomized, placebo-controlled trial. Canadian Medical Association Journal (CMAJ), 184(10), 1143-1150. https://doi.org/10.1503/cmaj.110837

 

Crane, M. (2021). Dangers of marijuana: Long-term effects of pot on the brain and body. American Addiction Centers. https://americanaddictioncenters.org/marijuana-rehab/long-term-effects

 

Freeman, T. P., & Winstock, A. R. (2015). Examining the profile of high-potency cannabis and its association with severity of cannabis dependence. Psychological Medicine, 45(15), 3181-3189. https://doi.org/10.1017/S0033291715001178

 

Government of Canada. (2019). Cannabis: Lower your risks. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/resources/lower-your-risks.html

 

Government of Canada. (2020). Canadian cannabis survey 2020: Summaryhttps://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/canadian-cannabis-survey-2020-summary.html#a4

 

Greco, R., Gasperi, V., Maccarrone, M., & Tassorelli, C. (2010). The endocannabinoid system and migraine. Experimental Neurology, 224(1), 85-91. https://doi.org/10.1016/j.expneurol.2010.03.029

 

Green, B., Kavanagh, D., & Young, R. (2003). Being stoned: A review of self-reported cannabis effects. Drug and Alcohol Review, 22(4), 453-460. https://doi.org/10.1080/09595230310001613976

 

Grewal, J. K., & Loh, L. C. (2020). Health considerations of the legalization of cannabis edibles. Canadian Medical Association Journal (CMAJ), 192(1), E1-E2. https://doi.org/10.1503/cmaj.191217

 

Grewal. S., & George. T. (2017). Cannabis-induced psychosis: A review. Psychiatric Times, 34(7). https://www.psychiatrictimes.com/view/cannabis-induced-psychosis-review

 

Hall, W. (2015). What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? Addiction (Abingdon, Endlang), 110(1), 19-35. https://doi.org/10.1111/add.12703

 

Hamilton, H. A., Brands, B., Ialomiteanu, A. R., & Mann, R. E. (2017). Therapeutic use of cannabis: Prevalence and characteristics among adults in ontario, canada. Canadian Journal of Public Health, 108(3), e282-e287. https://doi.org/10.17269/CJPH.108.6130

 

Hasin, D. S., Saha, T. D., Kerridge, B. T., Goldstein, R. B., Chou, S. P., Zhang, H., Jung, J., Pickering, R. P., Ruan, W. J., Smith, S. M., Huang, B., & Grant, B. F. (2015). Prevalence of marijuana use disorders in the united states between 2001-2002 and 2012-2013. JAMA Psychiatry, 72(12), 1235-1242. https://doi.org/10.1001/jamapsychiatry.2015.1858

 

Holt. J. (2021, January 18). The pros and cons of using marijuana recreationally. Grow Diaries.  https://growdiaries.com/journal/the-pros-and-cons-of-using-cannabis-recreationally

 

Jones, K. A., Blagrove, M., & Parrott, A. C. (2009). Cannabis and ecstasy/mdma: Empirical measures of creativity in recreational users. Journal of Psychoactive Drugs, 41(4), 323-329. https://doi.org/10.1080/02791072.2009.10399769

 

Joy, J. E., Watson, S. J., Benson, J. A., NetLibrary, I., Institute of Medicine (U.S.). Division of Neuroscience and Behavioral Health, & Institute of Medicine. (1999;2000;2005;). In Janet E. Joy, John A. Benson J. and Stanley J. Watson J.(Eds.), Marijuana and medicine: Assessing the science base. National Academy Press. https://doi.org/10.17226/6376

 

Kouri, E., Pope, H. G., Yurgelun-Todd, D., & Gruber, S. (1995). Attributes of heavy vs. occasional marijuana smokers in a college population. Biological Psychiatry (1969), 38(7), 475-481. https://doi.org/10.1016/0006-3223(94)00325-W

 

Ksir, C., & Hart, C. L. (2016). Cannabis and psychosis: A critical overview of the relationship. Current Psychiatry Reports, 18(2), 1-11. https://doi.org/10.1007/s11920-015-0657-y

 

Lachenmeier, D. W., & Rehm, J. (2015). Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach. Scientific Reports, 5(1), 8126. https://doi.org/10.1038/srep08126

 

Liu, Q., Wu, Z., Liu, Y., Chen, L., Zhao, H., Guo, H., Zhu, K., Wang, W., Chen, S., Zhou, N.,Li, Y., & Shi, B. (2020). Cannabinoid receptor 2 activation decreases severity of cyclophosphamide‐ induced cystitis via regulating autophagy. Neurourology and Urodynamics, 39(1), 158-169. https://doi.org/10.1002/nau.24205

 

Long and short-term effects of cannabis. (2018, June 21). Portage. https://portage.ca/en/blog/long-and-short-term-effects-of-cannabis/

 

MacCallum, C.A., & Russo, E. B. (2018). Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine, 49, 12-19. https://doi.org/10.1016/j.ejim.2018.01.004

 

Mundell, E., J. (2020, March 18). One joint may cause psychotic symptoms: Study. A Family Pharmacy Apple Valley. https://www.afamilypharmacy.com/patient-resources/article/755848/one-joint-may-cause-psychotic-symptoms-study

 

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. (2017). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12.  https://doi.org/10.17226/24625

 

Peki, W. (2021). 61 potential benefits of marijuana and its cannabinoids that are backed by scientific research. Herbonaut. https://www.herbonaut.com/benefits-of-marijuana/

 

Ramo, D. E., Delucchi, K. L., Hall, S. M., Liu, H., & Prochaska, J. J. (2013). Marijuana and tobacco co-use in young adults: Patterns and thoughts about use. Journal of Studies on Alcohol and Drugs, 74(2), 301-310. https://doi.org/10.15288/jsad.2013.74.301

 

Ramos Barreda, A., De Leon, K., & Urmas, S. (2018). A simple guide to pot, thc and how much is too much. LA Times. https://www.latimes.com/projects/la-me-weed-101-thc-calculator/

 

Reiman, A. (2009). Cannabis as a substitute for alcohol and other drugs. Harm Reduction Journal, 6(1), 35-35. https://doi.org/10.1186/1477-7517-6-35

 

Rosenberg, E. C., Tsien, R. W., Whalley, B. J., & Devinsky, O. (2015). Cannabinoids and epilepsy. Neurotherapeutics, 12(4), 747-768. https://doi.org/10.1007/s13311-015-0375-5

 

Rubinstein, M. L., Rait, M. A., & Prochaska, J. J. (2014). Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers. Drug and Alcohol Dependence, 141, 159-162. https://doi.org/10.1016/j.drugalcdep.2014.05.015

 

Szaflarski, Jerzy P., MD, PhD, & Devinsky, O. (2017). Cannabinoids and epilepsy —introduction. Epilepsy & Behavior, 70(Pt B), 277-277. https://doi.org/10.1016/j.yebeh.2017.01.015

 

Wall, J., Davis, S., & Ridgway, S. (2001). Cannabis: Its therapeutic use. Nursing Standard, 16(10), 39-44. https://doi.org/10.7748/ns2001.11.16.10.39.c3123

 

Ware, M. A., Wang, T., Shapiro, S., Robinson, A., Ducruet,T., Huynh, T., Gamsa, A., Bennett, G. J., & Collet, J. (2010). Smoked cannabis for chronic neuropathic pain: A randomized controlled trial. Canadian Medical Association Journal (CMAJ), 182(14), E694-E701. https://doi.org/10.1503/cmaj.091414

 

Watkins. M., (2020, August 17). Marijuana (weed, cannabis) overdose symptoms, signs & treatment. American Addictions Centers. https://drugabuse.com/drugs/marijuana/overdose/

 

Webb, C. W., & Webb, S. M. (2014). Therapeutic benefits of cannabis: A patient survey.Hawai'i Journal of Medicine & Public Health, 73(4), 109-111. https://pubmed.ncbi.nlm.nih.gov/24765558/

 

Weckowicz, T. E. (1975). Effect of marijuana on divergent and convergent production cognitive tests. Journal of Abnormal Psychology (1965), 84(4), 386-398. https://doi.org/10.1037/0021-843X.84.4.386

 

World Health Organization. (2016). The health and social effects of nonmedical cannabis use. https://apps.who.int/iris/handle/10665/251056

 

Armstrong, M. J. (2018, October 16). Legal cannabis vs. black market: Can it compete? The Conversation. Retrieved February 1, 2020, from https://theconversation.com/legal-cannabis-vs-black-market-can-it-compete-104915.

 

Ashton, C. H. (2001). Pharmacology and effects of cannabis: A brief review. British Journal of Psychiatry, 178(2), 101-106. https://doi.org/10.1192/bjp.178.2.101

 

Beirness, D. J., & Porath-Waller, A. J. (2019). Clearing the smoke on cannabis: Cannabis use and driving -an update. Canadian Centre on Substance Abuse. https://www.ccsa.ca/sites/default/files/2019-10/CCSA-Cannabis-Use-Driving-Report-2019-en_1.pdf

 

Berghaus, G., & Guo, B.L. (1995). Medicines and driver fitness—findings from a meta-analysis of experimental studies as basic information to patients, physicians, and experts. Transportation Research Board. https://trid.trb.org/view/470158

 

Bjorge, P. (2020, March 4). Cannabis tinctures 101: How to make, consume, and dose them. Leafly.https://www.leafly.ca/news/cannabis-101/cannabis-tinctures-101-what-are-they-how-to-make-them-and-how-to

 

Boone, S. (2021, April 16). Curious about the indica vs. sativa debate? Learn the real difference. Scary Mommy. https://www.scarymommy.com/indica-vs-sativa/#:~:text=Indica%20plants%20are%20short%20and%20stocky%20with%20broad,written%20records%20of%20their%20distinct%20genetics%20and%20evolution.

 

Borodovsky, J. T., Crosier, B. S., Lee, D. C., Sargent, J. D., & Budney, A. J. (2016). Smoking, vaping, eating: Is legalization impacting the way people use cannabis? The International Journal of Drug Policy, 36, 141-147. https://doi.org/10.1016/j.drugpo.2016.02.022

 

Boshkova, M., (2018). Why do people smoke weed? The top 12 reasons. Higher Mentality. https://www.highermentality.com/why-people-smoke-weed/

 

Capler, R. (2009). Why people use cannabis. Visions: BC’s Mental Health and Substance Use Journal, 5(4), 9. https://www.heretohelp.bc.ca/why-people-use-cannabis

 

Duvall, C., S, (2019). “Decriminalization doesn’t erase marijuana’s class and race problems.” Opposing viewpoints online collection, Gale, 2019. www.gale.com. Originally published as “Decriminalization doesn’t address marijuana’s standing as a drug of the poor,” The Conversation, 31 Mar. 2015. https://www.gale.com/open-access/marijuana

 

Fataar, F., Goodman, S., Wadsworth, E., & Hammond, D. (2021). Consumer perceptions of ‘legal’ and ‘illegal’ cannabis in us states with legal cannabis sales. Addictive Behaviors, 112, 106563-106563. https://doi.org/10.1016/j.addbeh.2020.106563

 

Franciosi, A. (2017). THC patch: The ultimate guide to thc transdermal patches. Honest Marijuana. https://honestmarijuana.com/thc-patch/

 

Fraser, G., A., (2009). The use of a synthetic cannabinoid in the management of treatment-resistant nightmares in posttraumatic stress disorder (PTSD). CNS Neuroscience & Therapeutics, 15(1), 84-88. https://doi.org/10.1111/j.1755-5949.2008.00071.x

 

Gilbert, A. N., & DiVerdi, J. A. (2018). Consumer perceptions of strain differences in cannabis aroma. PloS One, 13(2), e0192247-e0192247. https://doi.org/10.1371/journal.pone.0192247

 

Government of Canada. (2019). What you need to know before you choose to consume cannabishttps://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/resources/wHat-you-need-to-know-if-you-choose-to-consume-cannabis.html

 

Government of Canada. (2020). Canadian Cannabis Survey 2020: Summaryhttps://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/canadian-cannabis-survey-2020-summary.html#a2

 

Government of Canada. (2020). What you need to know about cannabis. https://www.canada.ca/en/services/health/campaigns/cannabis/canadians.html#a7

 

Government of Ontario. (2021). Cannabis and driving. Learn about the laws and penalties, and how cannabis affects your driving. https://www.ontario.ca/page/cannabis-and-driving

 

Hartman, R. L., Brown, T. L., Milavetz, G., Spurgin, A., Pierce, R. S., Gorelick, D. A., Gaffney, G., & Huestis, M. A. (2015). Cannabis effects on driving lateral control with and without alcohol. Drug and Alcohol Dependence, 154, 25-37. https://doi.org/10.1016/j.drugalcdep.2015.06.015

 

Hartman, R. L., & Huestis, M. A. (2013). Cannabis effects on driving skills. Clinical Chemistry (Baltimore, Md.), 59(3), 478-492. https://doi.org/10.1373/clinchem.2012.194381

 

Hartogsohn, I. (2017). Constructing drug effects: A history of set and setting. Drug Science, Policy and Law. https://doi.org/10.1177/2050324516683325

 

Holland, K. (2021). Sativa vs. indica: What to expect across cannabis types and strains. Healthline. https://www.healthline.com/health/sativa-vs-indica

 

Huestis, M. A. (2007). Human cannabinoid pharmacokinetics. Chemistry & Biodiversity, 4(8), 1770- 1804. https://doi.org/10.1002/cbdv.200790152

 

Legal vs. illegal: Inside canada’s marketplace. (2020). Responsible Cannabis Use. https://thercu.org/blogs/blog/legal-vs-illegal-inside-canada-s-cannabis-marketplace

 

Livingston, L., (2018). 6 uses for indica cannabis strains. Buy My Weed Online. https://buymyweedonline.com/marijuana/6-uses-for-indica/

 

MADD. (n.d.). Cannabis and driving. https://madd.ca/pages/impaired-driving/overview/cannabis-and-driving/

 

Martin, T. L., Solbeck, P. A. M., Mayers, D. J., Langille, R. M., Buczek, Y., & Pelletier, M. R. (2013). A review of alcohol-impaired driving: The role of blood alcohol concentration and complexity of the driving task. Journal of Forensic Sciences, 58(5), 1238-1250. https://doi.org/10.1111/1556-4029.12227

 

McPartland, J. M., & Small, E. (2020). A classification of endangered high-thc cannabis (cannabis sativa subsp. indica) domesticates and their wild relatives. Phytokeys, 144(2), 81-112. https://doi.org/10.3897/phytokeys.144.46700

 

Moore, T. R. (2002). A primer of drug action: A concise nontechnical guide to the actions, uses, and side effects of psychoactive drugs, ninth edition. American Journal of Health-System Pharmacy, 59(11), 1130-1131. https://doi.org/10.1093/ajhp/59.11.1130a

 

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. (2017). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12. https://doi.org/10.17226/24625

 

Parnes, J. E., Bravo, A. J., Conner, B. T., & Pearson, M. R. (2018). A burning problem:Cannabis lessons learned from Colorado. Addiction Research & Theory, 26(1), 3-10. https://doi.org/10.1080/16066359.2017.1315410

 

Ramaekers, J. G., Robbe, H. W. J., & O'Hanlon, J. F. (2000). Marijuana, alcohol and actual driving performance. Human Psychopharmacology, 15(7), 551-558. https://doi.org/10.1002/1099-1077(200010)15:7<551::AID-HUP236>3.0.CO;2-P

 

Rosado, J., (2019). Cannabis hybrids. Marijuana Doctors. https://www.marijuanadoctors.com/resources/cannabis-hybrids/

 

Rotermann, M. (2019). National cannabis survey 2nd quarter. Statistics Canada. https://www150.statcan.gc.ca/n1/en/catalogue/11-627-M2019057

 

Safe Cannabis Guide. (n.d.). Methods of cannabis consumption. https://www.safecannabisuse.com/dosing/

 

Society for the Study of Ingestive Behavior. (2018, July 17). How cannabis affects appetite: brain changes. ScienceDaily. Retrieved June 27, 2021 from www.sciencedaily.com/releases/2018/07/180717094747.htm

 

Statistics Canada. (2019, October 30). National cannabis survey, third quarter 2019. https://www150.statcan.gc.ca/n1/daily-quotidien/191030/dq191030a-eng.htm

 

The Cannabis Advisory. (n.d.). How soon after using cannabis can you drive?  https://www.thecannabisadvisory.com/cannabis-news/after-using-cannabis-can-drive/

 

Tringale, R., & Jensen, C. (2011). Cannabis and insomniahttp://files7.webydo.com/92/9209805/UploadedFiles/5E9EC245-448E-17B2-C7CA-21C6BDC6852D.pdf

 

Vincent, P. C., Collins, R. L., Liu, L., Yu, J., De Leo, J. A., & Earleywine, M. (2017). Theeffects of perceived quality on behavioral economic demand for marijuana: A web-based experiment. Drug and Alcohol Dependence, 170, 174-180. https://doi.org/10.1016/j.drugalcdep.2016.11.013

 

Volkow, N. (2015). The biology and potential therapeutic effects of cannabidiol. National Institute on Drug Abuse. https://archives.drugabuse.gov/testimonies/2015/biology-potential-therapeutic-effects-cannabidiol#:~:text=CBD%20has%20shown%20therapeutic%20efficacy,measures%20of%20stress%20and%20anxiety.&text=In%20addition%2C%20CBD%20has%20shown,human%20laboratory%20and%20clinical%20trials.

 

White, J, (n.d.). Cannabis Sativa - What is Cannabis Sativa? A guide to sativa marijuana strains, their effects and medical uses, and how they work. CNBS. https://www.cnbs.org/cannabis-types/cannabis-sativa/

 

Abajobir, A. A., Najman, J. M., Williams, G., Strathearn, L., Clavarino, A., & Kisely, S. (2017). Substantiated childhood maltreatment and young adulthood cannabis use disorders: A pre-birth cohort study. Psychiatry Research, 256, 21-31. https://doi.org/10.1016/j.psychres.2017.06.017

 

Abrams, D. I. (2016). Integrating cannabis into clinical cancer care. Current Oncology (Toronto), 23(2), S8-14. https://doi.org/10.3747/co.23.3099

 

Abrams, D. I. (2018). The therapeutic effects of cannabis and cannabinoids: An update from the national academies of sciences, engineering and medicine report. European Journal of Internal Medicine, 49, 7-11. https://doi.org/10.1016/j.ejim.2018.01.003

 

Abulseoud, O. A., Zuccoli, M. L., Zhang, L., Barnes, A., Huestis, M. A., & Lin, D. (2017). The acute effect of cannabis on plasma, liver and brain ammonia dynamics, a translational study. European Neuropsychopharmacology, 27(7), 679-690. https://doi.org/10.1016/j.euroneuro.2017.03.006 

 

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596

 

Andreae, M. H., Carter, G. M., Shaparin, N., Suslov, K., Ellis, R. J., Ware, M. A., Abrams, D. I., Prasad, H., Wilsey, B., Indyk, D., Johnson, M., & Sacks, H. S. (2015). Inhaled cannabis for chronic neuropathic pain: a meta-analysis of individual patient data. The Journal of Pain, 16(12), 1221-1232. https://doi.org/10.1016/j.jpain.2015.07.009

 

Babson, K. A., & Bonn-Miller, M. O. (2014). Sleep disturbances: Implications for cannabis use, cannabis use cessation, and cannabis use treatment. Current Addiction Reports, 1(2), 109-114. https://doi.org/10.1007/s40429-014-0016-9

 

Babson, K. A., Sottile, J., & Morabito, D. (2017). Cannabis, cannabinoids, and sleep: A review of the literature. Current Psychiatry Reports, 19(4), 1-12. https://doi.org/10.1007/s11920-017-0775-9

 

Bar-Sela, G., Zalman, D., Semenysty, V., & Ballan, E. (2019). The effects of dosage-controlled cannabis capsules on cancer-related cachexia and anorexia syndrome in advanced cancer patients: Pilot study. Integrative Cancer Therapies, 18, 1534735419881498. https://doi.org/10.1177/1534735419881498

 

Baron, E. P., Lucas, P., Eades, J., & Hogue, O. (2018). Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort. Journal of Headache and Pain, 19(1), 1-28. https://doi.org/10.1186/s10194-018-0862-2

 

Barrus, D. G., Capogrossi, K. L., Cates, S. C., Gourdet, C. K., Peiper, N. C., Novak, S. P., Lefever, T. W., & Wiley, J. L. (2016). Tasty thc: Promises and challenges of cannabis edibles. Methods Report (RTI Press), 2016, 10.3768/rtipress.2016.op.0035.1611. https://doi.org/10.3768/rtipress.2016.op.0035.1611

 

BC Lung Foundation. (2019). Cannabis and Lung Healthhttps://bclung.ca/how-we-can-help/cannabis-and-lung-health

 

Beal, K. (2019). Considerations in the addition of cannabis to chocolate. Current Opinion in Food Science, 28, 14-17. https://doi.org/10.1016/j.cofs.2019.02.007

 

Berghuis, P., Rajnicek, A. M., Morozov, Y. M., Ross, R. A., Mulder, J., Urbán, G. M., Monory, K., Marsicano, G., Matteoli, M., Canty, A., Irving, A. J., Katona, I., Yanagawa, Y., Rakic, P., Lutz, B., Mackie, K., & Harkany, T. (2007). Hardwiring the brain: Endocannabinoids shape neuronal connectivity. Science (New York, N.Y.), 316(5828), 1212-1216. https://doi.org/10.1126/science.1137406

 

Bhattacharyya, S., Fusar-Poli, P., Borgwardt, S., Martin-Santos, R., O'Carroll, C., Crippa, J., Atakan, Z., & McGuire, P. (2009). P. 3.02 Opposite neural effects of the main psychoactive ingredients of cannabis—implications for therapeutics. European Neuropsychopharmacology, 19, S63-S64. https://doi.org/10.1016/S0924-977X(09)70072-0

 

Blake, A., & Nahtigal, I. (2019). The evolving landscape of cannabis edibles. Current Opinion in Food Science, 28, 25-31. https://doi.org/10.1016/j.cofs.2019.03.009

 

Boden, M. T., Babson, K. A., Vujanovic, A. A., Short, N. A., & Bonn-Miller, M. O. (2013). Posttraumatic stress disorder and cannabis use characteristics among military veterans with cannabis dependence. The American Journal on Addictions, 22(3), 277-284. https://doi.org/10.1111/j.1521-0391.2012.12018.x

 

Bolanis, D., Orri, M., Castellanos-Ryan, N., Renaud, J., Montreuil, T., Boivin, M., Vitaro, F., Tremblay, R. E., Turecki, G., Cote, S. M., Seguin, J. R., & Geoffroy, M. C. (2020). Cannabis use, depression and suicidal ideation in adolescence: direction of associations in a population based cohort. Journal of Affective Disorders, 274, 1076-1083. https://doi.org/10.1016/j.jad.2020.05.136

 

Bonn-Miller, M. O., Babson, K. A., & Vandrey, R. (2013;2014;). Using cannabis to help you sleep: Heightened frequency of medical cannabis use among those with ptsd. Drug and Alcohol Dependence, 136, 162-165. https://doi.org/10.1016/j.drugalcdep.2013.12.008

 

Brierley, D. I., Samuels, J., Duncan, M., Whalley, B. J., & Williams, C. M. (2016).Cannabigerol is a novel, well-tolerated appetite stimulant in pre-satiated rats. Psychopharmacology, 233(19), 3603-3613. https://doi.org/10.1007/s00213-016-4397-4

 

Brubacher, J. R., Chan, H., & Staples, J. A. (2020). Cannabis-impaired driving and canadian youth. Paediatrics & Child Health, 25(Supplement_1), S21-S25. https://doi.org/10.1093/pch/pxaa017

 

Buckner, J. D., Jeffries, E. R., Crosby, R. D., Zvolensky, M. J., Cavanaugh, C. E., & Wonderlich, S. A. (2018). The impact of ptsd clusters on cannabis use in a racially diverse trauma-exposed sample: An analysis from ecological momentary assessment. The American Journal of Drug & Alcohol Abuse, 44(5), 532–542. https://doi.org/10.1080/00952990.2018.1430149

 

Budney, A. J., Hughes, J. R., Moore, B. A., & Vandrey, R. (2004). Review of the validity and significance of cannabis withdrawal syndrome. The American Journal of Psychiatry, 161(11), 1967-1977. https://doi.org/10.1176/appi.ajp.161.11.1967

 

Budney, A. J., Moore, B. A., Vandrey, R. G., & Hughes, J. R. (2003). The time course and significance of cannabis withdrawal. Journal of Abnormal Psychology, 112(3), 393–402. https://doi.org/10.1037/0021-843X.112.3.393

 

Budney, A. J., Sargent, J. D., & Lee, D. C. (2015). Vaping cannabis (marijuana): Parallel concerns to e‐cigs? Addiction (Abingdon, England), 110(11), 1699-1704. https://doi.org/10.1111/add.13036

 

Burggren, A. C., Shirazi, A., Ginder, N., & London, E. D. (2019). Cannabis effects on brain structure, function, and cognition: Considerations for medical uses of cannabis and its derivatives. The American Journal of Drug and Alcohol Abuse, 45(6), 563-579. https://doi.org/10.1080/00952990.2019.1634086

 

Butterworth, P., Slade, T., & Degenhardt, L. (2014). Factors associated with the timing and onset of cannabis use and cannabis use disorder: Results from the 2007 australian national survey of mental health and well‐being. Drug and Alcohol Review, 33(5), 555-564. https://doi.org/10.1111/dar.12183

 

Capler, R. (2009). Why people use cannabis. Visions: BC’s Mental Health and Substance Use Journal, 5(4), 9. https://www.heretohelp.bc.ca/why-people-use-cannabis

 

Casadio, P., Fernandes, C., Murray, R. M., & Di Forti, M. (2011). Cannabis use in youngpeople: The risk for schizophrenia. Neuroscience and Biobehavioral Reviews, 35(8), 1779-1787. https://doi.org/10.1016/j.neubiorev.2011.04.007

 

Chang, L., Yakupov, R., Cloak, C., & Ernst, T. (2006). Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain (London, England: 1878), 129(5), 1096-1112. https://doi.org/10.1093/brain/awl064

 

Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. (2018). Self‐initiated use of topical cannabidiol oil for epidermolysis bullosa. Pediatric Dermatology, 35(4), e224-e227. https://doi.org/10.1111/pde.13545

 

Chinnappa, N. B., Zalewska, K., & Mckeon, D. (2014). P60 cannabis lung causing debilitating emphysema: Are we on the verge of an epidemic? Thorax, 69(Suppl 2), A101-A101. https://doi.org/10.1136/thoraxjnl-2014-206260.201

 

Colizzi, M., McGuire, P., Giampietro, V., Williams, S., Brammer, M., & Bhattacharyya, S. (2018). Previous cannabis exposure modulates the acute effects of delta-9-tetrahydrocannabinol on attentional salience and fear processing. Experimental and Clinical Psychopharmacology, 26(6), 582-598. https://doi.org/10.1037/pha0000221

 

Colizzi, M., Tosato, S., & Ruggeri, M. (2020). Cannabis and cognition: Connecting the dots towards the understanding of the relationship. Brain Sciences, 10(3), 133. https://doi.org/10.3390/brainsci10030133

 

Corey-Bloom, J., Wolfson, T., Gamst, A., Jin, S., Marcotte, T. D., Bentley, H., & Gouaux, B. (2012). Smoked cannabis for spasticity in multiple sclerosis: A randomized, placebo-controlled trial. Canadian Medical Association Journal (CMAJ), 184(10), 1143-1150. https://doi.org/10.1503/cmaj.110837

 

Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., & Goudriaan, A. E. (2014). Effect of baseline cannabis use and working‐memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study. Human Brain Mapping, 35(5), 2470-2482. https://doi.org/10.1002/hbm.22342

 

Crippa, J. A., Zuardi, A. W., Martín-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., & Fusar-Poli, P. (2009). Cannabis and anxiety: A critical review of the evidence. Human Psychopharmacology, 24(7), 515-523. https://doi.org/10.1002/hup.1048

 

Curry, B., & Gould, S. (2018). Scoping review: Medicinal benefits of cannabis related to stimulating appetite in populations at risk for nutritional deficiency. Journal of the Academy of Nutrition and Dietetics, 118(10), A123-A123. https://doi.org/10.1016/j.jand.2018.08.015

 

D'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004). The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis. Neuropsychopharmacology, 29(8), 1558-1572. https://doi.org/10.1038/sj.npp.1300496

 

Dahlgren, M. K., Sagar, K. A., Smith, R. T., Lambros, A. M., Kuppe, M. K., & Gruber, S. A. (2020). Recreational cannabis use impairs driving performance in the absence of acute intoxication. Drug and Alcohol Dependence, 208, 107771. https://doi.org/10.1016/j.drugalcdep.2019.107771

 

Danielsson, A. K., Lundin, A., Agardh, E., Allebeck, P., & Forsell, Y. (2016). Cannabis use, depression and anxiety: A 3-year prospective population-based study. Journal of Affective Disorders, 193, 103-108. https://doi.org/10.1016/j.jad.2015.12.045

 

Davis, G. P., Compton, M. T., Wang, S., Levin, F. R., & Blanco, C. (2013). Association between cannabis use, psychosis, and schizotypal personality disorder: Findings from the national epidemiologic survey on alcohol and related conditions. Schizophrenia Research, 151(1), 197-202. https://doi.org/10.1016/j.schres.2013.10.018

 

De Aquino, J. P., Sofuoglu, M., Stefanovics, E. A., & Rosenheck, R. A. (2020). Impact of cannabis on non-medical opioid use and symptoms of posttraumatic stress disorder: A nationwide longitudinal va study. The American Journal of Drug and Alcohol Abuse, 46(6), 812-822. https://doi.org/10.1080/00952990.2020.1818248

 

Defoe, I. N., Khurana, A., Betancourt, L. M., Hurt, H., & Romer, D. (2019). Disentangling longitudinal relations between youth cannabis use, peer cannabis use, and conduct problems: Developmental cascading links to cannabis use disorder. Addiction (Abingdon, England), 114(3), 485–493. https://doi.org/10.1111/add.14456

 

Degenhardt, L., Hall, W., & Lynskey, M. (2003). Exploring the association between cannabis use and depression. Addiction, 98(11), 1493-1504. https://doi.org/10.1046/j.1360-0443.2003.00437.x

 

Denson, T. F., & Earleywine, M. (2006). Decreased depression in marijuana users. Addictive Behaviors, 31(4), 738-742. https://doi.org/10.1016/j.addbeh.2005.05.052

 

Donoghue, K., Doody, G. A., Murray, R. M., Jones, P. B., Morgan, C., Dazzan, P., Hart, J., Mazzoncini, R., & MacCabe, J. H. (2014). Cannabis use, gender and age of onset of schizophrenia: Data from the ÆSOP study. Psychiatry Research, 215(3), 528-532. https://doi.org/10.1016/j.psychres.2013.12.038

 

Drummer, O. H., Gerostamoulos, D., & Woodford, N. W. (2019). Cannabis as a cause of death: A review. Forensic Science International, 298, 298-306. https://doi.org/10.1016/j.forsciint.2019.03.007

 

Duncan, A. E., Sartor, C. E., Scherrer, J. F., Grant, J. D., Heath, A. C., Nelson, E. C., Jacob, T., & Bucholz, K. K. (2008). The association between cannabis abuse and dependence and childhood physical and sexual abuse: Evidence from an offspring of twins design. Addiction, 103(6), 990-997. https://doi.org/10.1111/j.1360-0443.2008.02210.x

 

Duran, M., Pérez, E., Abanades, S., Vidal, X., Saura, C., Majem, M., Arriola, E., Rabanal, M., Pastor, A., Farre, M., Rams, N., Laporte, J. R., & Capellà, D. (2010). Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy‐induced nausea and vomiting. British Journal of Clinical Pharmacology, 70(5), 656-663. https://doi.org/10.1111/j.1365-2125.2010.03743.x

 

Dworkin, E. R., Kaysen, D., Bedard-Gilligan, M., Rhew, I. C., & Lee, C. M. (2017). Daily-level associations between ptsd and cannabis use among young sexual minority women. Addictive Behaviors, 74, 118-121. https://doi.org/10.1016/j.addbeh.2017.06.007

 

Earleywine, M., & Barnwell, S. S. (2007). Decreased respiratory symptoms in cannabis users who vaporize. Harm Reduction Journal, 4(1), 11. https://doi.org/10.1186/1477-7517-4-11

 

Ellgren, M., Artmann, A., Tkalych, O., Gupta, A., Hansen, H.S., Hansen, S.H., Devi, L. A., & Hurd, Y. L. (2008). Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: Thc effects. European Neuropsychopharmacology, 18(11), 826-834. https://doi.org/10.1016/j.euroneuro.2008.06.009

 

Farokhnia, M., McDiarmid, G. R., Newmeyer, M. N., Munjal, V., Abulseoud, O. A., Huestis, M. A., & Leggio, L. (2020). Effects of oral, smoked, and vaporized cannabis on endocrine pathways related to appetite and metabolism: A randomized, double-blind, placebo-controlled, human laboratory study. Translational Psychiatry, 10(1), 71. https://doi.org/10.1038/s41398-020-0756-3

 

Farrimond, J. A., Whalley, B. J., & Williams, C. M. (2010). A low-Δ9tetrahydrocannabinol cannabis extract induces hyperphagia in rats. Behavioural Pharmacology, 21(8), 769-772. https://doi.org/10.1097/FBP.0b013e328340a062

 

Feingold, D., Weiser, M., Rehm, J., & Lev-Ran, S. (2016). The association between cannabis use and anxiety disorders: Results from a population-based representative sample. European Neuropsychopharmacology, 26(3), 493-505. https://doi.org/10.1016/j.euroneuro.2015.12.037

 

Fischer, B., Jeffries, V., Hall, W., Room, R., Goldner, E., & Rehm, J. (2011). Lower risk cannabis use guidelines for canada (lrcug): A narrative review of evidence and recommendations. Canadian Journal of Public Health, 102(5), 324-327. https://doi.org/10.1007/BF03404169

 

Fischer, B., Russell, C., Sabioni, P., van den Brink, W., Le Foll, B., Hall, W., Rehm, J., & Room, R. (2017). Lower-risk cannabis use guidelines: A comprehensive update ofevidence and recommendations. American Journal of Public Health (1971), 107(8), E1-E12. https://doi.org/10.2105/AJPH.2017.303818 

 

Gaffal, E., Cron, M., Glodde, N., & Tüting, T. (2013). Anti‐inflammatory activity of topical thc in dnfb‐mediated mouse allergic contact dermatitis independent of cb1 and cb2 receptors. Allergy, 68(8), 994-1000. https://doi.org/10.1111/all.12183

 

Gage, S. H., Jones, H. J., Burgess, S., Bowden, J., Davey Smith, G., Zammit, S., & Munafò, M. R. (2017). Assessing causality in associations between cannabis use and schizophrenia risk: A two-sample mendelian randomization study. Psychological Medicine, 47(5), 971-980. https://doi.org/10.1017/S0033291716003172

 

Galli, J. A., Sawaya, R. A., & Friedenberg, F. K. (2011). Cannabinoid hyperemesis syndrome. Current Drug Abuse Reviews, 4(4), 241–249. https://doi.org/10.2174/1874473711104040241

 

Gates, P., Jaffe, A., & Copeland, J. (2014). Cannabis smoking and respiratory health: Consideration of the literature. Respirology (Carolton, Vic.), 19(5), 655-662. https://doi.org/10.1111/resp.12298

 

Gieringer, D., St. Laurent, J., & Goodrich, S. (2004). Cannabis vaporizer combines efficient delivery of thc with effective suppression of pyrolytic compounds. Journal of Cannabis Therapeutics, 4(1), 7-27. https://doi.org/10.1300/J175v04n01_02

 

Government of Canada. (2021). Addiction to cannabis. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/health-effects/addiction.html

 

Graham, V. E., & Clough, A. R. (2019). "Need everyone helping to keep off because everyone helping to keep on" - reducing harms from cannabis use in remote indigenous australian communities involves more than just users. Substance use & Misuse, 54(5), 699-712. https://doi.org/10.1080/10826084.2018.1504078

 

Green, B. O. B., Kavanagh, D., & Young, R. (2003). Being stoned: A review of self‐reported cannabis effects. Drug and Alcohol Review, 22(4), 453-460. https://doi.org/10.1080/09595230310001613976

 

Grewal, J. K., & Loh, L. C. (2020). Health considerations of the legalization of cannabis edibles. Canadian Medical Association Journal (CMAJ), 192(1), E1-E2. https://doi.org/10.1503/cmaj.191217 

 

Griffith-Lendering, M. F. H., Wigman, J. T. W., Prince van Leeuwen, A., Huijbregts, S. C. J., Huizink, A. C., Ormel, J., Verhulst, F. C., van Os, J., Swaab, H., & Vollebergh, W. A. M. (2013). Cannabis use and vulnerability for psychosis in early adolescence - A trails study. Addiction (Abingdon, England), 108(4), 733-740.https://doi.org/10.1111/add.12050

 

Grotenhermen, F. (1999). The effects of cannabis and thc. Forschende Komplementarmedizin, 6 Suppl 3, 7-11. https://doi.org/10.1159/000057149

 

Grotenhermen, F. (2001). Harm reduction associated with inhalation and oral administration of cannabis and thc. Journal of Cannabis Therapeutics, 1(3-4), 133-152. https://doi.org/10.1300/J175v01n03_09 

 

Grotenhermen, F. (2003). Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical Pharmacokinetics, 42(4), 327-360. https://doi.org/10.2165/00003088-200342040-00003

 

Grotenhermen, F. (2004). Cannabinoids for therapeutic use: Designing systems to increase efficacy and reliability. American Journal of Drug Delivery, 2(4), 229-240. https://doi.org/10.2165/00137696-200402040-00003

 

Gustavsen, S., Søndergaard, HB., Linnet, K., Thomsen, R., Rasmussen, BS., Sorensen, PS., Sellebjerg, F., & Oturai, AB. (2021). Safety and efficacy of low-dose medical cannabis oils in multiple sclerosis. Multiple Sclerosis and Related Disorders, 48, 102708-102708. https://doi.org/10.1016/j.msard.2020.102708

 

Habboushe, J., Rubin, A., Liu, H., & Hoffman, R. S. (2018). The prevalence of cannabinoid hyperemesis syndrome among regular marijuana smokers in an urban public hospital. Basic & Clinical Pharmacology & Toxicology, 122(6), 660-662. https://doi.org/10.1111/bcpt.12962

 

Halladay, J. E., Boyle, M. H., Munn, C., Jack, S. M., & Georgiades, K. (2019). Sex differences in the association between cannabis use and suicidal ideation and attempts, depression, and psychological distress among canadians. Canadian Journal of Psychiatry, 64(5), 345-350. https://doi.org/10.1177/0706743718804542

 

Hancox, R. J., Poulton, R., Ely, M., Welch, D., Taylor, D. R., McLachlan, C. R., Greene, J. M., Moffitt, T. E., Caspi, A., & Sears, M. R. (2010). Effects of cannabis on lung function: A population-based cohort study. The European Respiratory Journal, 35(1), 42–47. https://doi.org/10.1183/09031936.00065009

 

Hancox, R. J., Shin, H. H., Gray, A. R., Poulton, R., & Sears, M. R. (2015). Effects of quitting cannabis on respiratory symptoms. The European Respiratory Journal, 46(1), 80-87. https://doi.org/10.1183/09031936.00228914

 

Harvey, M. A., Sellman, J. D., Porter, R. J., & Frampton, C. M. (2007). The relationship between non-acute adolescent cannabis use and cognition. Drug and Alcohol Review, 26(3), 309-319. https://doi.org/10.1080/09595230701247772

 

Hasin, D. S., Kerridge, B. T., Saha, T. D., Huang, B., Pickering, R., Smith, S. M., Jung, J., Zhang, H., & Grant, B. F. (2016). Prevalence and correlates of dsm-5 cannabis use disorder, 2012-2013: Findings from the national epidemiologic survey on alcohol and related conditions–III. The American Journal of Psychiatry, 173(6), 588-599. https://doi.org/10.1176/appi.ajp.2015.15070907

 

Hawke, L. D., Wilkins, L., & Henderson, J. (2020). Early cannabis initiation: Substance use and mental health profiles of service-seeking youth. Journal of Adolescence, 83, 112-121. https://doi.org/10.1016/j.adolescence.2020.06.004

 

Hazekamp, A., Ruhaak, R., Zuurman, L., van Gerven, J., & Verpoorte, R. (2006). Evaluation of a vaporizing device (volcano®) for the pulmonary administration of tetrahydrocannabinol. Journal of Pharmaceutical Sciences, 95(6), 1308-1317. https://doi.org/10.1002/jps.20574

 

Hernandez, J. M., Paty, J., & Price, I. M. (2018). Cannabinoid hyperemesis syndrome presentation to the emergency department: A two-year multicentre retrospective chart review in a major urban area. Canadian Journal of Emergency Medicine, 20(4), 550- 555. https://doi.org/10.1017/cem.2017.381

 

Hezode, C., Roudot-Thoraval, F., Nguyen, S., Grenard, P., Julien, B., Zafrani, E., Pawlostky, J., Dhumeaux, D., Lotersztajn, S., & Mallat, A. (2005). Daily cannabis smoking as a risk factor for progression of fibrosis in chronic hepatitis c. Hepatology (Baltimore, MD.), 42(1), 63-71. https://doi.org/10.1002/hep.20733

 

Hodgson, K., Coleman, J. R. I., Hagenaars, S. P., Purves, K. L., Glanville, K., Choi, S. W., O'Reilly, P., Breen, G., Lewis, C. M., & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. (2020). Cannabis use, depression and self‐harm: Phenotypic and genetic relationships. Addiction (Abingdon, England), 115(3), 482-492. https://doi.org/10.1111/add.14845

 

Horwood, L. J., Fergusson, D. M., Coffey, C., Patton, G. C., Tait, R., Smart, D., Letcher, P., Silins, E., & Hutchinson, D. M. (2012). Cannabis and depression: An integrative data analysis of four australasian cohorts. Drug and Alcohol Dependence, 126(3), 369-378. https://doi.org/10.1016/j.drugalcdep.2012.06.002

 

Jager, G., Kahn, R. S., Van Den Brink, W., Van Ree, J.,M., & Ramsey, N. F. (2006). Long-term effects of frequent cannabis use on working memory and attention: An fMRI study. Psychopharmacology, 185(3), 358-68. https://doi.org/10.1007/s00213-005-0298-7

 

Jager, G., Van Hell, H. H., De Win, M. M., Kahn, R.S., Van Den Brink, W., Van Ree, J. M., Ramsey, N. F. (2007). Effects of frequent cannabis use on hippocampal activity during an associative memory task. European Neuropsychopharmacology, 17(4), 289-297. https://doi.org/10.1016/j.euroneuro.2006.10.003

 

Jennings, J. M., Johnson, R. M., Brady, A. C., & Dennis, D. A. (2020). Patient perception regarding potential effectiveness of cannabis for pain management. The Journal of Arthroplasty, 35(12), 3524-3527. https://doi.org/10.1016/j.arth.2020.06.051

 

Johnson, M. J., Pierce, J. D., Mavandadi, S., Klaus, J., Defelice, D., Ingram, E., & Oslin, D. W. (2015;2016;). Mental health symptom severity in cannabis using and non-using veterans with probable ptsd. Journal of Affective Disorders, 190, 439-442. https://doi.org/10.1016/j.jad.2015.10.048

 

Johnson, S. B., Blum, R. W., & Giedd, J. N. (2009). Adolescent maturity and the brain: The promise and pitfalls of neuroscience research in adolescent health policy. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 45(3), 216–221. https://doi.org/10.1016/j.jadohealth.2009.05.016

 

Jones, C. B., Meier, M. H., & Pardini, D. A. (2018). Comparison of the locations where young adults smoke, vape, and eat/drink cannabis: Implications for harm reduction. Addictive Behaviors Reports, 8, 140-146. https://doi.org/10.1016/j.abrep.2018.09.002

 

Joshi, M., Joshi, A., & Bartter, T. (2014). Marijuana and lung diseases. Current Opinion in Pulmonary Medicine, 20(2), 173-179. https://doi.org/10.1097/MCP.0000000000000026

 

Kanayama, G., Rogowska, J., Pope, H. G., Gruber, S. A., & Yurgelun-Todd, D. A. (2004). Spatial working memory in heavy cannabis users: A functional magnetic resonance imaging study. Psychopharmacology, 176(3), 239-247. https://doi.org/10.1007/s00213-004-1885-8

 

Kedzior, K. K., & Laeber, L. T. (2014). A positive association between anxiety disorders and cannabis use or cannabis use disorders in the general population--a meta-analysis of 31 studies. BMC Psychiatry, 14(1), 136. https://doi.org/10.1186/1471-244X-14-136

 

Kevorkian, S., Bonn-Miller, M. O., Belendiuk, K., Carney, D. M., Roberson-Nay, R., & Berenz, E. C. (2015). Associations among trauma, posttraumatic stress disorder, cannabis use, and cannabis use disorder in a nationally representative epidemiologic sample. Psychology of Addictive Behaviors, 29(3), 633. https://doi.org/10.1037/adb0000110

 

Khalili, M. A., & Rasulzadeh, M. (2011). Spasticity: A review of methods for assessment and treatment. Iranian Rehabilitation Journal, 9(14), 60-64. http://irj.uswr.ac.ir/article-1-262-en.pdf

 

King, C., & Holmes, A. (2015). Cannabinoid hyperemesis syndrome. Canadian Medical Association Journal (CMAJ), 187(5), 355. https://doi.org/10.1503/cmaj.140154

 

Koppel, B. S., Brust, J. C., Fife, T., Bronstein, J., Youssof, S., Gronseth, G., & Gloss, D. (2014). Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders: Report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology, 82(17), 1556-1563. https://doi.org/10.1212/WNL.0000000000000363

 

Kosiba, J. D., Maisto, S. A., & Ditre, J. W. (2019). Patient-reported use of medical cannabis for pain, anxiety, and depression symptoms: Systematic review and meta-analysis. Social Science & Medicine (1982), 233, 181-192. https://doi.org/10.1016/j.socscimed.2019.06.005

 

Koskinen, J., Lohonen, J., Koponen, H., Isohanni, M., & Miettunen, J. (2010). Rate of cannabis use disorders in clinical samples of patients with schizophrenia: A meta-analysis. Schizophrenia Bulletin, 36(6), 1115-1130.https://doi.org/10.1093/schbul/sbp031

 

Kroon, E., Kuhns, L., Hoch, E., & Cousijn, J. (2020). Heavy cannabis use, dependence and the brain: A clinical perspective. Addiction (Abingdon, England), 115(3), 559-572. https://doi.org/10.1111/add.14776

 

Lamy, F. R., Daniulaityte, R., Sheth, A., Nahhas, R. W., Martins, S. S., Boyer, E. W., & Carlson, R. G. (2016). “Those edibles hit hard”: Exploration of twitter data on cannabisedibles in the u.s. Drug and Alcohol Dependence, 164, 64-70. https://doi.org/10.1016/j.drugalcdep.2016.04.029 

 

Lau, N., Sales, P., Averill, S., Murphy, F., Sato, S. O., & Murphy, S. (2015). Responsible and controlled use: Older cannabis users and harm reduction. The International Journal of Drug Policy, 26(8), 709-718. https://doi.org/10.1016/j.drugpo.2015.03.008

 

Leberl, M., Kratzer, A., & Taraseviciene-Stewart, L. (2013). Tobacco smoke induced copd/emphysema in the animal model—are we all on the same page? Frontiers in Physiology, 4, 91-91. https://doi.org/10.3389/fphys.2013.00091

 

Lee, C. M., Neighbors, C., & Woods, B. A. (2007). Marijuana motives: Young adults' reasons for using marijuana. Addictive behaviors, 32(7), 1384-1394. https://doi.org/10.1016/j.addbeh.2006.09.010

 

Lee, D. C., Crosier, B. S., Borodovsky, J. T., Sargent, J. D., & Budney, A. J. (2016). Online survey characterizing vaporizer use among cannabis users. Drug and Alcohol Dependence, 159, 227-233. https://doi.org/10.1016/j.drugalcdep.2015.12.020

 

Lee, M. H., & Hancox, R. J. (2011). Effects of smoking cannabis on lung function. Expert Review of Respiratory Medicine, 5(4), 537-46. https://doi.org/10.1586/ers.11.40

 

Lev-Ran, S., Roerecke, M., Le Foll, B., George, T. P., McKenzie, K., & Rehm, J. (2014). The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies. Psychological Medicine, 44(4), 797-810. https://doi.org/10.1017/S0033291713001438

 

Levy, J., Buhl, K., Fernandez, C., & Jayaram, K. (2020). Does smoking cannabis increase the risk of barrett’s esophagus? Cureus (Palo Alto, CA), 12(2), e6913. https://doi.org/10.7759/cureus.6913

 

Li, X., Vigil, J. M., Stith, S. S., Brockelman, F., Keeling, K., & Hall, B. (2019). The effectiveness of self-directed medical cannabis treatment for pain. Complementary Therapies in Medicine, 46, 123-130. https://doi.org/10.1016/j.ctim.2019.07.022

 

Livne, O., Shmulewitz, D., Lev-Ran, S., & Hasin, D. S. (2019). Dsm-5 cannabis withdrawal syndrome: Demographic and clinical correlates in u.s. adults. Drug and Alcohol Dependence, 195, 170-177.https://doi.org/10.1016/j.drugalcdep.2018.09.005

 

Loflin, M., & Earleywine, M. (2015). No smoke, no fire: What the initial literature suggests regarding vapourized cannabis and respiratory risk. Canadian Journal of Respiratory Therapy: CJRT, 51(1), 7-9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456813/

 

Lopez-Quintero, C., Cobos, José Pérez de los, Hasin, D. S., Okuda, M., Wang, S., Grant, B. F., & Blanco, C. (2010;2011;). Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: Results of the national epidemiologic survey on alcohol and related conditions (nesarc). Drug and Alcohol Dependence, 115(1), 120-130. https://doi.org/10.1016/j.drugalcdep.2010.11.004

 

Luque, J. S., Okere, A. N., Reyes-Ortiz, C. A., & Williams, P. M. (2021). Mixed methods study of the potential therapeutic benefits from medical cannabis for patients in florida. Complementary Therapies in Medicine, 57, 102669. https://doi.org/10.1016/j.ctim.2021.102669

 

Maida, V., & Corban, J. (2017). Topical medical cannabis: A new treatment for wound pain—three cases of pyoderma gangrenosum. Journal of Pain and Symptom Management, 54(5), 732-736. https://doi.org/10.1016/j.jpainsymman.2017.06.005

 

Maida, V., Shi, R. B., Fazzari, F. G. T., & Zomparelli, L. (2021). Topical cannabis-based medicines - A novel adjuvant treatment for venous leg ulcers: An open-label trial. Experimental Dermatology, 30(9), 1258-1267. https://doi.org/10.1111/exd.14395

 

Malone, D. T., Hill, M. N., & Rubino, T. (2010). Adolescent cannabis use and psychosis: Epidemiology and neurodevelopmental models. British journal of pharmacology, 160(3), 511-522. https://doi.org/10.1111/j.1476-5381.2010.00721.x

 

Martin, R., Safaee, S. D., Somsamouth, K., Mounivong, B., Sinclair, R., Bansal, S., & Singh, P. N. (2013). Mixed methods pilot study of sharing behaviors among waterpipe smokers of rural lao pdr: Implications for infectious disease transmission. International Journal of Environmental Research and Public Health, 10(6), 2120-2132. https://doi.org/10.3390/ijerph10062120 

 

Mehra, R., Moore, B. A., Crothers, K., Tetrault, J., & Fiellin, D. A. (2006). The association between marijuana smoking and lung cancer: A systematic review. Archives of Internal Medicine, 166(13), 1359-1367. https://doi.org/10.1001/archinte.166.13.1359

 

Michael G. DeGroote Centre for Medicinal Cannabis Research. (2018). What effects does smoking cannabis have on the respiratory system? McMaster University MDCMCR. https://cannabisresearch.mcmaster.ca/news/2018/04/27/cannabis-smoking-and-effects-on-the-respiratory-system

 

Moir, D., Rickert, W. S., Levasseur, G., Larose, Y., Maertens, R., White, P., & Desjardins, S. (2008). A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions. Chemical Research in Toxicology, 21(2), 494-502. https://doi.org/10.1021/tx700275p

 

Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M., & Lewis, G. (2007). Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review. Lancet (London, England), 370(9584), 319-328. https://doi.org/10.1016/S0140-6736(07)61162-3

 

Murphy, J., Houston, J. E., Shevlin, M., & Adamson, G. (2013). Childhood sexual trauma, cannabis use and psychosis: Statistically controlling for pre-trauma psychosis and psychopathology. Social Psychiatry and Psychiatric Epidemiology, 48(6), 853-861. https://doi.org/10.1007/s00127-012-0592-8

 

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. (2017). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12. https://doi.org/10.17226/24625

 

National Institute of Mental Health. (n.d.). What is psychosis? https://www.nimh.nih.gov/health/topics/schizophrenia/raise/what-is-psychosis

 

Nicholson, A. N., Turner, C., Stone, B. M., & Robson, P. J. (2004). Effect of Δ-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. Journal of Clinical Psychopharmacology, 24(3), 305-313. https://doi.org/10.1097/01.jcp.0000125688.05091.8f

 

Nugent, S. M., Morasco, B. J., O'Neil, M. E., Freeman, M., Low, A., Kondo, K., Elven, C., Zakher, B., Motu’apuaka, M., Paynter, R., & Kansagara, D. (2017). The effects of cannabis among adults with chronic pain and an overview of general harms: A systematic review. Annals of Internal Medicine, 167(5), 319-331. https://doi.org/10.7326/M17-0155

 

Ogeil, R. P., Cheetham, A., Mooney, A., Allen, N. B., Schwartz, O., Byrne, M. L., Simmons, J. G., Whittle, S., & Lubman, D. I. (2019). Early adolescent drinking and cannabis use predicts later sleep-quality problems. Psychology of Addictive Behaviors, 33(3), 266- 273. https://doi.org/10.1037/adb0000453

 

Ogeil, R. P., Phillips, J. G., Rajaratnam, S. M., & Broadbear, J. H. (2015). Risky drug use and effects on sleep quality and daytime sleepiness. Human Psychopharmacology: Clinical and Experimental, 30(5), 356-363. https://doi.org/10.1002/hup.2483

 

Ogle, W., Coppen, L., & Copriviza, C. (2020). Beyond the runners high: Cannabis and exercise: 2311 board# 230 may 28 2: 00 PM-3: 30 PM. Medicine & Science in Sports & Exercise, 52(7S), 621. https://doi.org/10.1249/01.mss.0000681040.70825.cc

 

Osborne, G. B., & Fogel, C. (2008). Understanding the motivations for recreational marijuana use among adult canadians. Substance use & Misuse, 43(3-4), 539-587. https://doi.org/10.1080/10826080701884911

 

Papatheodorou, S.I., Buettner, H., Rice, M.B., & Mittleman, M.A. (2016). Recent marijuana use and associations with exhaled nitric oxide and pulmonary function in adults in the united states. Chest, 149(6), 1428-1435. https://doi.org/10.1016/j.chest.2015.12.033

 

Park, J. Y., & Wu, L. T. (2017). Prevalence, reasons, perceived effects, and correlates ofmedical marijuana use: A review. Drug and Alcohol Dependence, 177, 1-13. https://doi.org/10.1016/j.drugalcdep.2017.03.009

 

Patel, S., Khan, S., Saipavankumar, M., & Pousettef, H. (2020). The association between cannabis use and schizophrenia: Causative or curative? A systematic review. Cureus, 12(7), e9309. https://doi.org/10.7759/cureus.9309

 

Patton, G. C., Coffey, C., Carlin, J. B., Degenhardt, L., Lynskey, M., & Hall, W. (2002). Cannabis use and mental health in young people: Cohort study. BMJ (Clinical Research Ed.), 325(7374), 1195-1198. https://doi.org/10.1136/bmj.325.7374.1195

 

Pergolizzi Jr, J. V., LeQuang, J. A., & Bisney, J. F. (2018). Cannabinoid hyperemesis. Medical Cannabis and Cannabinoids, 1(2), 73-95. https://doi.org/10.1159/000494992

 

Pope Jr, H. G., Gruber, A. J., Hudson, J. I., Cohane, G., Huestis, M. A., & Yurgelun-Todd, D.(2003). Early-onset cannabis use and cognitive deficits: What is the nature of the association? Drug and Alcohol Dependence, 69(3), 303-310. https://doi.org/10.1016/s0376-8716(02)00334-4

 

Power, R. A., Verweij, K. J. H., Zuhair, M., Montgomery, G. W., Henders, A. K., Heath, A. C., Madden, P. A. F., Medland, S. E., Wray, N. R., & Martin, N. G. (2014). Genetic predisposition to schizophrenia associated with increased use of cannabis. Molecular Psychiatry, 19(11), 1201-1204. https://doi.org/10.1038/mp.2014.51

 

Pratt, M., Stevens, A., Thuku, M., Butler, C., Skidmore, B., Wieland, L. S., Clemons, M., Kanji, S., & Hutton, B. (2019). Benefits and harms of medical cannabis: A scoping review of systematic reviews. Systematic Reviews, 8(1), 320-320. https://doi.org/10.1186/s13643-019-1243-x

 

Reilly, D., Didcott, P., Swift, W., & Hall, W. (1998). Long‐term cannabis use: Characteristics of users in an australian rural area. Addiction (Abingdon, England), 93(6), 837-846. https://doi.org/10.1046/j.1360-0443.1998.9368375.x

 

Riggs, P. K., Vaida, F., Rossi, S. S., Sorkin, L. S., Gouaux, B., Grant, I., & Ellis, R. J. (2012). A pilot study of the effects of cannabis on appetite hormones in hiv-infected adult men. Brain Research, 1431, 46-52. https://doi.org/10.1016/j.brainres.2011.11.001

 

Roberts, C. A., Jager, G., Christiansen, P., & Kirkham, T. C. (2019). Exploring the munchies: An online survey of users’ experiences of cannabis effects on appetite and the development of a cannabinoid eating experience questionnaire. Journal of Psychopharmacology (Oxford, England), 33(9), 1149-1159. https://doi.org/10.1177/0269881119862526

 

Rock, E. M., Bolognini, D., Limebeer, C. L., Cascio, M. G., Anavi‐Goffer, S., Fletcher, P. J., Mechoulam, R., Pertwee, R. G., & Parker, L. A. (2012). Cannabidiol, a non‐psychotropic component of cannabis, attenuates vomiting and nausea‐like behaviour via indirect agonism of 5‐ht(1a) somatodendritic autoreceptors in the dorsal raphe nucleus. British Journal of Pharmacology, 165(8), 2620-2634. https://doi.org/10.1111/j.1476-5381.2011.01621.x

 

Rooke, S. E., Norberg, M. M., Copeland, J., & Swift, W. (2013). Health outcomes associated with long-term regular cannabis and tobacco smoking. Addictive Behaviors, 38(6), 2207-2213. https://doi.org/10.1016/j.addbeh.2013.01.013 

 

Ruiz-Veguilla, M., Barrigón, M. L., Hernández, L., Rubio, J. L., Gurpegui, M., Sarramea, F., Cervilla, J., Gutiérrez, B., James, A., & Ferrin, M. (2013). Dose–response effect between cannabis use and psychosis liability in a non-clinical population: Evidence from a snowball sample. Journal of Psychiatric Research, 47(8), 1036-1043. https://doi.org/10.1016/j.jpsychires.2013.03.003

 

Schoeler, T., Kambeitz, J., Behlke, I., Murray, R., & Bhattacharyya, S. (2016). The effects of cannabis on memory function in users with and without a psychotic disorder: Findings from a combined meta-analysis. Psychological Medicine, 46(1), 177-188. https://doi.org/10.1017/S0033291715001646

 

Schreiner, A. M., & Dunn, M. E. (2012). Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: A meta-analysis. Experimental and Clinical Psychopharmacology, 20(5), 420-429. https://doi.org/10.1037/a0029117

 

Sharpe, L., Sinclair, J., Kramer, A., de Manincor, M., & Sarris, J. (2020). Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties. Journal of Translational Medicine, 18(1), 374. https://doi.org/10.1186/s12967-020-02518-2

 

Shiplo, S., Asbridge, M., Leatherdale, S. T., & Hammond, D. (2016). Medical cannabis use in canada: Vapourization and modes of delivery. Harm Reduction Journal, 13(1), 30-30. https://doi.org/10.1186/s12954-016-0119-9

 

Soriano-Co, M., Batke, M., & Cappell, M. S. (2010). The cannabis hyperemesis syndrome characterized by persistent nausea and vomiting, abdominal pain, and compulsive bathing associated with chronic marijuana use: A report of eight cases in the United States. Digestive Diseases and Sciences, 55(11), 3113–3119. https://doi.org/10.1007/s10620-010-1131-7

 

Stefani, A., Aramini, B., Baraldi, C., Pellesi, L., Della Casa, G., Morandi, U., & Guerzoni, S. (2020). Secondary spontaneous pneumothorax and bullous lung disease in cannabis and tobacco smokers: A case-control study. PloS One, 15(3), e0230419. https://doi.org/10.1371/journal.pone.0230419 

 

Suraev, A., Hoyos, C., Mills, L., McGregor, I., Bravo, M., Arkell, T., Benson, N., & Lintzeris, N. (2019). Cannabis use patterns for sleep disorders in australia: A subanalysis of an online cross‐sectional survey. Journal of Sleep Research, 28(S1). https://doi.org/10.1111/jsr.68_12912

 

Tan, W. C., Lo, C., Jong, A., Xing, L., Fitzgerald, M. J., Vollmer, W. M., Buist, S. A., & Sin, D. D., Vancouver Burden of Obstructive Lung Disease (BOLD) Research Group, & for the Vancouver Burden of Obstructive Lung Disease (BOLD) Research Group (2009). Marijuana and chronic obstructive lung disease: A population-based study. Canadian Medical Association Journal (CMAJ), 180(8), 814-820. https://doi.org/10.1503/cmaj.081040

 

Taylor, D. R., Fergusson, D. M., Milne, B. J., Horwood, L. J., Moffitt, T. E., Sears, M. R., & Poulton, R. (2002). A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults. Addiction (Abingdon, England), 97(8), 1055–1061. https://doi.org/10.1046/j.1360-0443.2002.00169.x

 

Tetrault, J. M., Crothers, K., Moore, B. A., Mehra, R., Concato, & J., Fiellin, D. A. (2007). Effects of marijuana smoking on pulmonary function and respiratory complications: A systematic review. Archives of Internal Medicine, 167(3), 221-228. https://doi.org/10.1001/archinte.167.3.221

 

Thu, K., Hayes, M., Miles, S., Tierney, L., & Foy, A. (2013). Marijuana ‘bong’ smoking and tuberculosis. Internal Medicine Journal, 43(4), 456-458. https://doi.org/10.1111/imj.12089

 

Tramèr, M. R., Carroll, D., Campbell, F. A., Reynolds, D. J. M., Moore, R. A., & McQuay, H. J. (2001). Cannabinoids for control of chemotherapy induced nausea and vomiting: Quantitative systematic review. BMG (Clinical Research Ed.), 323(7303), 16-21. https://doi.org/10.1136/bmj.323.7303.16

 

Tringale, R., & Jensen, C. (2011). Cannabis and insomniahttp://files7.webydo.com/92/9209805/UploadedFiles/5E9EC245-448E-17B2-C7CA-21C6BDC6852D.pdf

 

Van Dam, N. T., & Earleywine, M. (2010). Pulmonary function in cannabis users: Support for a clinical trial of the vaporizer. The International Journal of Drug Policy, 21(6), 511-513. https://doi.org/10.1016/j.drugpo.2010.04.001 

 

van der Pol, P., Liebregts, N., de Graaf, R., Korf, D. J., van den Brink, W., & van Laar, M. (2013). Predicting the transition from frequent cannabis use to cannabis dependence: A three-year prospective study. Drug and Alcohol Dependence, 133(2), 352-359. https://doi.org/10.1016/j.drugalcdep.2013.06.009

 

van Os, J., Bak, M., Hanssen, M., Bijl, R. V., de Graaf, R., & Verdoux, H. (2002). Cannabis use and psychosis: A longitudinal population-based study. American Journal of Epidemiology, 156(4), 319-327. https://doi.org/10.1093/aje/kwf043

 

Veen, N. D., Selten, J. P., van der Tweel, I., Feller, W. G., Hoek, H. W., & Kahn, R. S. (2004). Cannabis use and age at onset of schizophrenia. The American Journal of Psychiatry, 161(3), 501-506. https://doi.org/10.1176/appi.ajp.161.3.501

 

Verweij, K. J. H., Abdellaoui, A., Nivard, M. G., Sainz Cort, A., Ligthart, L., Draisma, H. H. M., Minică, C. C., & International Cannabis Consortium, Gillespie, N. A., Willemsen, G., Hottenga, J. J., Boomsma, D. I., & Vink, J. M. (2017). Short communication: Genetic association between schizophrenia and cannabis use. Drug and Alcohol Dependence, 171, 117-121. https://doi.org/10.1016/j.drugalcdep.2016.09.022

 

Wang, X., Dow-Edwards, D., Keller, E., & Hurd, Y. L. (2003). Preferential limbic expression of the cannabinoid receptor mrna in the human fetal brain. Neuroscience, 118(3), 681-694. https://doi.org/10.1016/s0306-4522(03)00020-4

 

Webb, C. W., & Webb, S. M. (2014). Therapeutic benefits of cannabis: A patient survey. Hawai'i Journal of Medicine & Public Health, 73(4), 109-111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/

 

Whiting, P. F., Wolff, R. F., Deshpande, S., Di Nisio, M., Duffy, S., Hernandez, A. V., Keurentjes, J. C., Lang, S., Misso, K., Ryder, S., Schmidlkofer, S., Westwood, M., & Kleijnen, J. (2015). Cannabinoids for medical use: A systematic review and meta-analysis. JAMA, 313(24), 2456-2473. https://doi.org/10.1001/jama.2015.6358

 

Winters, K. C., & Lee, C. S. (2008). Likelihood of developing an alcohol and cannabis use disorder during youth: Association with recent use and age. Drug and Alcohol Dependence, 92(1-3), 239-247. https://doi.org/10.1016/j.drugalcdep.2007.08.005

 

Wittchen, H., Fröhlich, C., Behrendt, S., Günther, A., Rehm, J., Zimmermann, P., Lieb, R., & Perkonigg, A. (2007). Cannabis use and cannabis use disorders and their relationship to mental disorders: A 10-year prospective-longitudinal community study in adolescents. Drug and Alcohol Dependence, 88 Suppl 1, S60-S70. https://doi.org/10.1016/j.drugalcdep.2006.12.013

 

Wu, J. H. (2014). Evidence brief: Communicable disease impacts of sharing electronic-cigarettes with drip tips. Public Health Ontario. https://www.publichealthontario.ca/-/media/documents/e/2014/eb-ecig-communicable-driptip.pdf?la=en

 

Wu, T. C., Tashkin, D. P., Djahed, B., & Rose, J. E. (1988). Pulmonary hazards of smoking marijuana as compared with tobacco. The New England Journal of Medicine, 318(6), 347–351. https://doi.org/10.1056/NEJM198802113180603

 

Yanes, J. A., Riedel, M. C., Ray, K. L., Kirkland, A. E., Bird, R. T., Boeving, E. R., Reid, M. A., Gonzalez, R., Robinson, J. L., Laird, A. R., & Sutherland, M. T. (2018). Neuroimaging meta-analysis of cannabis use studies reveals convergent functional alterations in brain regions supporting cognitive control and reward processing. Journal of Psychopharmacology (Oxford, England), 32(3), 283–295. https://doi.org/10.1177/0269881117744995

 

Zhang, L. R., Morgenstern, H., Greenland, S., Chang, S., Lazarus, P., Teare, M. D., Woll, P. J., Orlow, I., Cox, B., Brhane, Y., Liu, G., Hung, R. J., & on behalf of the Cannabis and Respiratory Disease Research Group of New Zealand. (2015). Cannabis smoking and lung cancer risk: Pooled analysis in the international lung cancer consortium: Cannabis smoking and lung cancer. International Journal of Cancer, 136(4), 894-903.  https://doi.org/10.1002/ijc.29036

 

Zhou, E. S., Nayak, M. M., Chai, P. R., & Braun, I. M. (2021). Cancer patient’s attitudes of using medicinal cannabis for sleep. Journal of Psychosocial Oncology, 1-7. https://doi.org/10.1080/07347332.2021.1910396

 

Abdallah, S. J., Smith, B. M., Ware, M. A., Moore, M., Li, P. Z., Bourbeau, J., & Jensen, D. (2018). Effect of vaporized cannabis on exertional breathlessness and exercise endurance in advanced chronic obstructive pulmonary disease: A randomized controlled trial. Annals of the American Thoracic Society, 15(10), 1146-1158. https://doi.org/10.1513/AnnalsATS.201803-198OC

 

Agrawal, A., Budney, A. J., & Lynskey, M. T. (2012). The co-occurring use and misuse of cannabis and tobacco: A review. Addiction (Abingdon, England), 107(7), 1221-1233. https://doi.org/10.1111/j.1360-0443.2012.03837.x

 

Allen, J. A., Davis, K. C., Duke, J. C., Nonnemaker, J. M., Bradfield, B. R., & Farrelly, M. C. (2017). New product trial, use of edibles, and unexpected highs among marijuana and hashish users in colorado. Drug and Alcohol Dependence, 176, 44-47. https://doi.org/10.1016/j.drugalcdep.2017.03.006

 

Al-Zouabi, I., Stogner, J. M., Miller, B. L., & Lane, E. S. (2018). Butane hash oil and dabbing: insights into use, amateur production techniques, and potential harm mitigation. Substance Abuse and Rehabilitation, 9, 91–101. https://doi.org/10.2147/SAR.S135252

 

Anderson, R. P., & Zechar, K. (2019). Lung injury from inhaling butane hash oil mimics pneumonia. Respiratory Medicine Case Reports, 26, 171-173. https://doi.org/10.1016/j.rmcr.2019.01.002

 

Baron, E. P. (2015). Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: What a long strange trip it's been. Headache, 55(6), 885-916. https://doi.org/10.1111/head.12570

 

Blake, A., & Nahtigal, I. (2019). The evolving landscape of cannabis edibles. Current Opinion in Food Science, 28, 25-31. https://doi.org/10.1016/j.cofs.2019.03.009

 

Calapai, F., Cardia, L., Sorbara, E. E., Navarra, M., Gangemi, S., Calapai, G., & Mannucci, C. (2020). Cannabinoids, Blood-Brain Barrier, and Brain Disposition. Pharmaceutics, 12(3), 265. https://doi.org/10.3390/pharmaceutics12030265

 

Cannabis-based medicines -Gw pharmaceuticals: High cbd, high thc, medicinal cannabis -Gw pharmaceuticals, thc:cbd. (2003). Drugs in R&D, 4(5), 306-309. https://doi.org/10.2165/00126839-200304050-00005

 

Chelliah, M. P., Zinn, Z., Khuu, P., & Teng, J. M. (2018). Self‐initiated use of topical cannabidiol oil for epidermolysis bullosa. Pediatric Dermatology, 35(4), e224-e227. https://doi.org/10.1111/pde.13545

 

Cinnamon Bidwell, L., YorkWilliams, S. L., Mueller, R. L., Bryan, A. D., & Hutchison, K. E. (2018). Exploring cannabis concentrates on the legal market: User profiles, product strength, and health-related outcomes. Addictive Behaviors Reports, 8, 102-106. https://doi.org/10.1016/j.abrep.2018.08.004

 

Cozzi, N. V. (1993). Effects of water filtration on marijuana smoke: A literature review. MAPS Bull, 4(2), 4-6. https://maps.org/news/bulletin/effects-of-water-filtration-on-marijuana-smoke/

 

Craft, S., Winstock, A., Ferris, J., Mackie, C., Lynskey, M. T., & Freeman, T. P. (2020;2019;). Characterising heterogeneity in the use of different cannabis products: Latent class analysis with 55 000 people who use cannabis and associations with severity of cannabis dependence. Psychological Medicine, 50(14), 2364-2373. https://doi.org/10.1017/S0033291719002460

 

Earleywine, M., & Barnwell, S. S. (2007). Decreased respiratory symptoms in cannabis users who vaporize. Harm Reduction Journal, 4(1), 1-4. https://doi.org/10.1186/1477-7517-4-11

 

Gaffal, E., Cron, M., Glodde, N., & Tüting, T. (2013). Anti‐inflammatory activity of topical thc in dnfb‐mediated mouse allergic contact dermatitis independent of cb1 and cb2 receptors. Allergy, 68(8), 994-1000. https://doi.org/10.1111/all.12183

 

Gates, P., Jaffe, A., & Copeland, J. (2014). Cannabis smoking and respiratory health: Consideration of the literature. Respirology (Carlton, Vic.), 19(5), 655-662. https://doi.org/10.1111/resp.12298

 

Gieringer, D. (1996). Marijuana water pipe and vaporizer study. MAPS Bull, 6(3), 59-66. https://maps.org/news-letters/v06n3/06359mj1.html

 

Gieringer, D. H. (2001). Cannabis "vaporization": A promising strategy for smoke harm reduction. Journal of Cannabis Therapeutics, 1(3-4), 153-170. https://doi.org/10.1300/J175v01n03_10

 

Government of Canada. (2019). Canadian cannabis survey 2019 –Summary.https://www.canada.ca/en/health-canada/services/publications/drugs-health-products/canadian-cannabis-survey-2019-summary.html

 

Government of Canada. (2019). Final regulations: Edible cannabis, cannabis extracts, cannabis topicalshttps://www.canada.ca/content/dam/hc-sc/documents/services/drugs-medication/cannabis/resources/final-regulations-edible-cannabis-extracts-topical-eng.pdf

 

Government of Canada. (2020). Canadian cannabis survey 2020: Summaryhttps://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/canadian-cannabis-survey-2020-summary.html#a2

 

Government of Canada. (2021, February 3). Cannabis legalization and regulationhttps://www.justice.gc.ca/eng/cj-jp/cannabis/

 

Grof, C. P. L. (2018). Cannabis, from plant to pill. British Journal of Clinical Pharmacology, 84(11), 2463-2467. https://doi.org/10.1111/bcp.13618

 

Grotenhermen, F. (2001). Harm reduction associated with inhalation and oral administration of cannabis and thc. Journal of Cannabis Therapeutics, 1(3-4), 133-152. https://doi.org/10.1300/J175v01n03_09

 

Grotenhermen, F. (2003). Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical Pharmacokinetics, 42(4), 327-360. https://doi.org/10.2165/00003088-200342040-00003

 

Grotenhermen, F., Russo, E., & Zuardi, A. W. (2017). Even high doses of oral cannabidiol do not cause thc-like effects in humans: Comment on merrick et al. cannabis and cannabinoid research 2016; 1 (1): 102–112; DOI: 10.1089/can. 2015.0004. Cannabis and Cannabinoid Research, 2(1), 1-4. https://doi.org/10.1089/can.2016.0036

 

Guy, G. W., Flint, M. E., Robson, P. J., & Whittle, B. A. (2000). A phase one study of sublingual cannabis-based medicine extract. Journal of Pharmacy and Pharmacology,52(9; SUPP/1), 294-294. https://eurekamag.com/research/034/314/034314323.php

 

Guy, R. H. (1996). Current status and future prospects of transdermal drug delivery. Pharmaceutical Research, 13(12), 1765-1769. https://doi.org/10.1023/a:1016060403438

 

GW Pharmaceuticals. (2012). Sativex Product Monograph, Salisbury, Wiltshire, UK. https://pdf.hres.ca/dpd_pm/00016162.PDF

 

Hakkarainen, P. (2016). Vaporizing the pot world –easy, healthy, and cool. Drugs and Alcohol Today, 16(3), 185-193. https://doi.org/10.1108/DAT-10-2015-0062

 

Hancox, R. J., Poulton, R., Ely, M., Welch, D., Taylor, D. R., McLachlan, C. R., Greene, J. M., Moffitt, T. E., Caspi, A., & Sears, M. R. (2010). Effects of cannabis on lung function: a population-based cohort study. The European Respiratory Journal, 35(1), 42–47. https://doi.org/10.1183/09031936.00065009

 

Happyana, N., Agnolet, S., Muntendam, R., Van Dam, A., Schneider, B., & Kayser, O. (2013). Analysis of cannabinoids in laser-microdissected trichomes of medicinal cannabis sativa using lcms and cryogenic nmr. Phytochemistry (Oxford), 87, 51-59. https://doi.org/10.1016/j.phytochem.2012.11.001

 

Hash. (2021, June 28). https://weedmaps.com/learn/dictionary/hash

 

Hawley, D., Graham, T., Stasiak, M., & Dixon, M. (2018). Improving cannabis bud quality and yield with subcanopy lighting. Hortscience, 53(11), 1593-1599. https://doi.org/10.21273/HORTSCI13173-18

 

Hazekamp, A., Ruhaak, R., Zuurman, L., van Gerven, J., & Verpoorte, R. (2006). Evaluation of a vaporizing device (volcano®) for the pulmonary administration of tetrahydrocannabinol. Journal of Pharmaceutical Sciences, 95(6), 1308-1317. https://doi.org/10.1002/jps.20574

 

He, T., Oks, M., Esposito, M., Steinberg, H., & Makaryus, M. (2017). “Tree-in-bloom”: Severe acute lung injury induced by vaping cannabis oil. Annals of the American Thoracic Society, 14(3). https://doi.org/10.1513/AnnalsATS.201612-974LE

 

Hess, C., Krämer, M., & Madea, B. (2017). Topical application of thc containing products is not able to cause positive cannabinoid finding in blood or urine. Forensic Science International, 272, 68-71. https://doi.org/10.1016/j.forsciint.2017.01.008

 

Hosseini, A.,McLachlan, A. J., & Lickliter, J. D. (2021). A phase I trial of the safety, tolerability and pharmacokinetics of cannabidiol administered as single‐dose oil solution and single and multiple doses of a sublingual wafer in healthy volunteers. British Journal of Clinical Pharmacology, 87(4), 2070-2077. https://doi.org/10.1111/bcp.14617

 

Howie, N., Trigkas, T., Cruchley, A., Wertz, P., Squier, C., & Williams, D. (2001). Short-term exposure to alcohol increases the permeability of human oral mucosa. Oral Diseases, 7(6), 349-354. https://doi.org/10.1034/j.1601-0825.2001.00731.x

 

Huestis M. A. (2007). Human cannabinoid pharmacokinetics. Chemistry & Biodiversity, 4(8), 1770–1804. https://doi.org/10.1002/cbdv.200790152

 

Jackson, D. K. & Hyatt, K. (2013). Silicone and hyaluronic acid (hla) delivery systems for products by sustainable processes for medical uses including wound management. (US Patent No. US2013/0184354 A1). https://patents.google.com/patent/US20130184354A1/en

 

Jin, D., Jin, S., & Chen, J. (2019). Cannabis indoor growing conditions, management practices, and post-harvest treatment: a review. American Journal of Plant Sciences, 10(6), 925. https://doi.org/10.4236/ajps.2019.106067

 

Johnson, J. R., Lossignol, D., Burnell-Nugent, M., & Fallon, M. T. (2013). An open-label extension study to investigate the long-term safety and tolerability of thc/cbd oromucosal spray and oromucosal thc spray in patients with terminal cancer-related pain refractory to strong opioid analgesics. Journal of Pain and Symptom Management, 46(2), 207-218. https://doi.org/10.1016/j.jpainsymman.2012.07.014

 

Joshi, M., Joshi, A., & Bartter, T. (2014). Marijuana and lung diseases. Current Opinion in Pulmonary Medicine, 20(2), 173-179. https://doi.org/10.1097/MCP.0000000000000026

 

Kado, J. (2020). Topical formulation for binding to dermatological cannabinoid receptors. (US Patent No. 10543176). https://patents.google.com/patent/US10543176B2/en?oq=U.S.+Patent+No.+10%2c543%2c176

 

Kamel, R. (2015). Transdermal drug delivery: Benefits and challenges. Journal of Applied Pharmacy, 8(1). https://doi.org/10.4172/1920-4159.1000e103

 

Kawahara, K., & Tojo, K. (2007). Skin irritation in transdermal drug delivery systems: A strategy for its reduction. Pharmaceutical Research, 24(2), 399-408. https://doi.org/10.1007/s11095-006-9165-4

 

Kliuk-Ben Bassat, O., Brill, S., Vaisman, N., Schechter, M., Ashtamker, N., Hirshberg, B., & Mosenzon, O. (2021). Pos-676 exploratory study to assess the safety of sublingual oil based medical cannabis bol-dp-o-04 in dialysis patients who have chronic pain. Kidney International Reports, 6(4), S295-S295. https://doi.org/10.1016/j.ekir.2021.03.707

 

Klumpers, L. E., Beumer, T. L., van Hasselt, J. G., Lipplaa, A., Karger, L. B., Kleinloog, H.D., Freijer, J. I., de Kam, M. L., & van Gerven, J. M. (2012). Novel Δ9‐tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects. British Journal of Clinical Pharmacology, 74(1), 42-53. https://doi.org/10.1111/j.1365-2125.2012.04164.x

 

Lamy, F. R., Daniulaityte, R., Zatreh, M.,Nahhas, R. W., Sheth, A., Martins, S. S., Boyer, E. W., & Carlson, R. G. (2018). "You got to love rosin: Solventless dabs, pure, clean, natural medicine." Exploring twitter data on emerging trends in rosin tech marijuana concentrates. Drug and Alcohol Dependence, 183, 248-252. https://doi.org/10.1016/j.drugalcdep.2017.10.039

 

Lee, M. H. S., & Hancox, R. J. (2011). Effects of smoking cannabis on lung function. Expert Review of Respiratory Medicine, 5(4), 537-547. https://doi.org/10.1586/ers.11.40

 

Loflin, M., & Earleywine, M. (2014). A new method of cannabis ingestion: The dangers of dabs? Addictive Behaviors, 39(10), 1430-1433. https://doi.org/10.1016/j.addbeh.2014.05.013

 

Maida, V., & Corban, J. (2017). Topical medical cannabis: A new treatment for wound pain—Three cases of pyoderma gangrenosum. Journal of Pain and Symptom Management, 54(5), 732-736. https://doi.org/10.1016/j.jpainsymman.2017.06.005

 

Maida, V., Shi, R. B., Fazzari, F. G. T., & Zomparelli, L. (2021). Topical cannabis-based medicines -A novel adjuvant treatment for venous leg ulcers: An open-label trial. Experimental Dermatology, 30(9), 1258-1267. https://doi.org/10.1111/exd.14395

 

Mariani, J. J., Brooks, D., Haney, M., & Levin, F. R. (2011). Quantification and comparison of marijuana smoking practices: Blunts, joints, and pipes. Drug and Alcohol Dependence, 113(2-3), 249-251. https://doi.org/10.1016/j.drugalcdep.2010.08.008

 

Marsot, A., Audebert, C., Attolini, L., Lacarelle, B., Micallef, J., & Blin, O. (2017). Population pharmacokinetics model of thc used by pulmonary route in occasional cannabis smokers. Journal of Pharmacological and Toxicological Methods, 85, 49-54. https://doi.org/10.1016/j.vascn.2017.02.003

 

McInnis, O. A., & Plecas, D. (2016). Clearing the smoke on cannabis: Respiratory effects of cannabis smoking: An update. Canadian Centre on Substance Abuse. https://www.ccsa.ca/sites/default/files/2019-04/CCSA-Cannabis-Use-Respiratory-Effects-Report-2016-en.pdf

 

Meier, M. H. (2017). Associations between butane hash oil use and cannabis-related problems. Drug and Alcohol Dependence, 179, 25-31. https://doi.org/10.1016/j.drugalcdep.2017.06.015

 

Michael G. DeGroote Centre for Medicinal Cannabis Research. (2018).What effects does smoking cannabis have on the respiratory system? McMaster University MDCMCR. https://cannabisresearch.mcmaster.ca/news/2018/04/27/cannabis-smoking-and-effects-on-the-respiratory-system

 

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. (2017). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12. https://doi.org/10.17226/24625

 

National Center for Chronic Disease Prevention and Health Promotion (US) Office on Smoking and Health. (2014). The health consequences of smoking—50 years of progress: A report of the surgeon general. Centers for Disease Control and Prevention (US). https://pubmed.ncbi.nlm.nih.gov/24455788/

 

OCS. (n.d.-a). Cannabis basics: Methods of consumption. https://ocs.ca/blogs/cannabis-basics/methods-of-consumption

 

OCS. (n.d.-b). Choosing cannabis products: Vaporizers vs. vapes: What’s the difference? https://ocs.ca/blogs/choosing-cannabis-products/vaporizers-vs-vapes-what-s-the-difference?index=ocs_articles&objectIDs=30531815244&queryID=f702b092338baed61343af5ee7bf3590

 

OCS. (n.d.-c). Extracts: Deep dive. https://ocs.ca/blogs/choosing-cannabis-products/extracts-deep-dive?index=ocs_articles&objectIDs=30529587020&queryID=c9d2d3b11ba2c0bc47edc49ebc255f20

 

OCS. (n.d.-d). How to clean a bong. https://ocs.ca/blogs/cannabis-how-tos/how-to-clean-a-bong?index=ocs_articles&objectIDs=30530701132&queryID=eababca6199dae7967fd91ecb3dc398e

 

OCS. (n.d.-e). Intro to live resin. https://ocs.ca/blogs/cannabis-basics/intro-to-live-resin?index=ocs_articles&objectIDs=30554556236&queryID=e8c384c1145b55517aa47e40466943e9

 

OCS. (n.d.-f). Intro to shatter. https://ocs.ca/blogs/cannabis-basics/intro-to-shatter?index=ocs_articles&objectIDs=30551541580&queryID=fbfee6a5e73dae7cb6619237e3d5d2a4

 

OCS. (n.d.-g). Intro to topicals. https://ocs.ca/blogs/cannabis-basics/intro-to-topicals

 

OCS. (n.d.-h). Rolling papers.https://ocs.ca/collections/rolling-papers?product=1314114307916&sort_by=products_priCe_per_uom_asc

 

Papaseit, E., Pérez-Mañá, C., Pérez-Acevedo, A. P., Hladun, O., Torres-Moreno, M. C., Muga, R., Torrens, M., & Farré, M. (2018). Cannabinoids: from pot to lab. International Journal of Medical Sciences, 15(12), 1286–1295. https://doi.org/10.7150/ijms.27087

 

Papatheodorou, S. I., Buettner, H., Rice, M. B., & Mittleman, M. A. (2016). Recent marijuana use and associations with exhaled nitric oxide and pulmonary function in adults in the united states. Chest, 149(6), 1428-1435. https://doi.org/10.1016/j.chest.2015.12.033

 

Peschel, W. (2016). Quality control of traditional cannabis tinctures: Pattern, markers, and stability. Scientia Pharmaceutica, 84(3), 567-584. https://doi.org/10.3390/scipharm84030567

 

Pierre, J. M., Gandal, M., & Son, M. (2016). Cannabis-induced psychosis associated with high potency “wax dabs”. Schizophrenia Research, 172(1-3), 211-212. https://doi.org/10.1016/j.schres.2016.01.056

 

Pomahacova, B., Van der Kooy, F., & Verpoorte, R. (2009). Cannabis smoke condensate III: The cannabinoid content of vaporised cannabis sativa. Inhalation Toxicology, 21(13), 1108-1112. https://doi.org/10.3109/08958370902748559

 

Raber, J. C., Elzinga, S., & Kaplan, C. (2015). Understanding dabs: Contamination concerns of cannabis concentrates and cannabinoid transfer during the act of dabbing. The Journal of Toxicological Sciences, 40(6), 797-803. https://doi.org/10.2131/jts.40.797

 

Riboulet-Zemouli, K. (2020). ‘Cannabis’ ontologies I: Conceptual issues with cannabis and cannabinoids terminology. Drug Science, Policy and Law, 6. https://doi.org/10.1177/2050324520945797

 

Ruchlemer, R., Amit-Kohn, M., Raveh, D., & Hanuš, L. (2015). Inhaled medicinal cannabis and the immunocompromised patient. Supportive Care in Cancer, 23(3), 819-822. https://doi.org/10.1007/s00520-014-2429-3

 

Russo E. B. (2011). Taming thc: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x

 

Sagar, K. A., Lambros, A. M., Dahlgren, M. K., Smith, R. T., & Gruber, S. A. (2018). Made from concentrate? A national web survey assessing dab use in the united states. Drug and Alcohol Dependence, 190, 133-142. https://doi.org/10.1016/j.drugalcdep.2018.05.022

 

Scully, C. (2007). Cannabis; adverse effects from an oromucosal spray. British Dental Journal, 203(6), E12-E37. https://doi.org/10.1038/bdj.2007.749

 

Seltenrich, N. (2019). Cannabis contaminants: Regulating solvents, microbes, and metals in legal weed. Environmental Health Perspectives, 127(8), 82001. https://doi.org/10.1289/EHP5785

 

Shakya, P., Madhav, N. V. S., Shakya, A. K., & Singh, K. (2011). Palatal mucosa as a route for systemic drug delivery: A review. Journal of Controlled Release, 151(1), 2-9. https://doi.org/10.1016/j.jconrel.2010.11.003

 

Skalicky, J., Husek, J., Hofbauerova, J., & Dittrich, M. (2012). A composition for the treatment of inflammatory diseases comprising boswellic acids and cannabidiol. (European Patent Application No. 2444081A1). https://patents.google.com/patent/EP2444081A1/en

 

Stephens D, Patel JK, Angelo D, Frunzi J. (2020). Cannabis butane hash oil dabbing induced lung injury mimicking atypical pneumonia. Cureus, 12(2), e7033. https://doi.org/10.7759/cureus.7033

 

Stinchcomb, A. L., Valiveti, S., Hammell, D. C., & Ramsey, D. R. (2004;2010;). Human skin permeation of Δ8-tetrahydrocannabinol, cannabidiol and cannabinol. Journal of Pharmacy and Pharmacology, 56(3), 291-297. https://doi.org/10.1211/0022357022791

 

Stockburger, S. (2016). Forms of administration of cannabis and their efficacy. Journal of Pain Management, 9(4), 381. https://www.researchgate.net/publication/316546304_Forms_of_administration_of_cannabis_and_their_efficacy

 

Stogner, J. M., & Miller, B. L. (2015). The dabbing dilemma: A call for research on butane hash oil and other alternate forms of cannabis use. Substance Abuse, 36(4), 393-395. https://doi.org/10.1080/08897077.2015.1071724

 

Taylor, D. R., Fergusson, D. M., Milne, B. J., Horwood, L. J., Moffitt, T. E., Sears, M. R., & Poulton, R. (2002). A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults. Addiction (Abingdon, England), 97(8), 1055-1061. https://doi.org/10.1046/j.1360-0443.2002.00169.x

 

Tetrault, J.M., Crothers, K., Moore, B.A., Mehra, R., Concato, & J., Fiellin, D.A. (2007). Effects of marijuana smoking on pulmonary function and respiratory complications: A systematic review. Archives of Internal Medicine, 167(3), 221-228. https://doi.org/10.1001/archinte.167.3.221

 

Thu, K., Hayes, M., Miles, S., Tierney, L., & Foy, A. (2013). Marijuana ‘bong’ smoking and tuberculosis. Internal Medicine Journal, 43(4), 456-458. https://doi.org/10.1111/imj.12089

 

Tijani, A. O., Thakur, D., Mishra, D., Frempong, D., Chukwunyere, U. I., & Puri, A. (2021). Delivering therapeutic cannabinoids via skin: Current state and future perspectives. Journal of Controlled Release, 334, 427-451. https://doi.org/10.1016/j.jconrel.2021.05.005

 

Touitou, E., Fabin, B., Dany, S., & Almog, S. (1988). Transdermal delivery of tetrahydrocannabinol. International Journal of Pharmaceutics, 43(1-2), 9-15. https://doi.org/10.1016/0378-5173(88)90052-X

 

Trofin, I. G., Dabija, G., Vaireanu, D. I., & Filipescu, L. (2012). Long-term storage and cannabis oil stability. Revista de Chimie, 63(3), 293-297. https://www.academia.edu/20127134/Long_term_Storage_and_Cannabis_Oil_Stability

 

Van Dam, N. T., & Earleywine, M. (2010). Pulmonary function in cannabis users: Support for a clinical trial of the vaporizer. International Journal on Drug Policy, 21(6), 511–513. https://doi.org/10.1016/j.drugpo.2010.04.001

 

Volkow, N. D., Baler, R. D., Compton, W. M., & Weiss, S. R. (2014). Adverse health effects of marijuana use. The New England Journal of Medicine, 370(23), 2219-2227. https://doi.org/10.1056/NEJMra1402309

 

Weed Maps. (n.d.-a). Bongs. https://weedmaps.com/learn/dictionary/bong

 

Weed Maps. (n.d.-b). Pipes. https://weedmaps.com/learn/dictionary/pipe

 

Weed Maps. (n.d.-c). What is distillate? https://weedmaps.com/learn/dictionary/distillate

 

Wu, T. C., Tashkin, D. P., Djahed, B., & Rose, J. E. (1988). Pulmonary hazards of smoking marijuana as compared with tobacco. The New England Journal of Medicine, 318(6), 347–351. https://doi.org/10.1056/NEJM198802113180603

 

Zhao, T., Cheng, K., Ott, W. R., Wallace, L., & Hildemann, L. M. (2020). Characteristics of secondhand cannabis smoke from common smoking methods: Calibration factor, emission rate, and particle removal rate. Atmospheric Environment (1994), 242, 117731. https://doi.org/10.1016/j.atmosenv.2020.117731

 

Zig Zag. (n.d.). Cigarette roller 78 mm. https://zigzag.com/products/78mm-cigarette-roller

 

Asbridge, M., Hayden, J. A., & Cartwright, J. L. (2012). Acute cannabis consumption and motor vehicle collision risk: Systematic review of observational studies and meta-analysis. BMJ (Online), 344, e536. https://doi.org/10.1136/bmj.e536

 

Asbridge, M., Mann, R., Cusimano, M. D., Trayling, C., Roerecke, M., Tallon, J. M., Whipp, A., & Rehm, J. (2014). Cannabis and traffic collision risk: Findings from a case- crossover study of injured drivers presenting to emergency departments. International Journal of Public Health, 59(2), 395-404. https://doi.org/10.1007/s00038-013-0512-z

 

Ball, A. L. (2007). Hiv, injecting drug use and harm reduction: A public health response. Addiction (Abingdon, England), 102(5), 684-690. https://doi.org/10.1111/j.1360-0443.2007.01761.x

 

Barrus, D. G., Capogrossi, K. L., Cates, S. C., Gourdet, C. K., Peiper, N. C., Novak, S. P., Lefever, T. W., & Wiley, J. L. (2016). Tasty thc: Promises and challenges of cannabis edibles. Methods Report (RTI Press), 2016, 10.3768/rtipress.2016.op.0035.1611. https://doi.org/10.3768/rtipress.2016.op.0035.1611

 

Batalla, A., Bhattacharyya, S., Yuecel, M., Fusar-Poli, P., Crippa, J. A., Nogue, S., Torrens, M., Pujol, J., Farre, M., & Martin-Santos, R. (2013). Structural and functional imaging studies in chronic cannabis users: A systematic review of adolescent and adult findings. PloS One, 8(2), e55821. https://doi.org/10.1371/journal.pone.0055821

 

Bédard, M., Dubois, S., & Weaver, B. (2007). The impact of cannabis on driving. Canadian Journal of Public Health, 98(1), 6-11. https://doi.org/10.1007/BF03405376

 

Bhattacharyya, S., Fusar-Poli, P., Borgwardt, S., Martin-Santos, R., O'Carroll, C., Crippa, J., Atakan, Z., & McGuire, P. (2009). P. 3.02 opposite neural effects of the main psychoactive ingredients of cannabis—Implications for therapeutics. European Neuropsychopharmacology, 19, S63-S64. https://doi.org/10.1016/S0924-977X(09)70072-0

 

Blake, A., & Nahtigal, I. (2019). The evolving landscape of cannabis edibles. Current Opinion in Food Science, 28, 25-31. https://doi.org/10.1016/j.cofs.2019.03.009

 

Canadian Nurses Association. (2017). Harm reduction for non-medical cannabis use. https://hl-prod-ca-oc-download.s3-ca-central-1.amazonaws.com/CNA/2f975e7e-4a40-45ca-863c-5ebf0a138d5e/UploadedImages/documents/Harm_Reduction_for_Non_Medical_Cannabis_Use.pdf

 

Cannabis Regulations (SOR/2018-144). https://laws-lois.justice.gc.ca/eng/regulations/sor-2018-144/

 

Coffey, C., Carlin, J. B., Degenhardt, L., Lynskey, M., Sanci, L., & Patton, G. C. (2002). Cannabis dependence in young adults: An australian population study. Addiction (Abingdon, England), 97(2), 187-194. https://doi.org/10.1046/j.1360-0443.2002.00029.x

 

D'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004). The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology, 29(8), 1558-1572. https://doi.org/10.1038/sj.npp.1300496

 

D’Souza, D. C., Sewell, R. A., & Ranganathan, M. (2009). Cannabis and psychosis/schizophrenia: Human studies. European Archives of Psychiatry and Clinical Neuroscience, 259(7), 413-431. https://doi.org/10.1007/s00406-009-0024-2

 

Earleywine, M., & Barnwell, S. S. (2007). Decreased respiratory symptoms in cannabis users who vaporize. Harm Reduction Journal, 4(1), 11. https://doi.org/10.1186/1477-7517-4-11

 

Einstein, S. (2007). Harm and risk reduction: History, theories, issues, and implications. Substance Use & Misuse, 42(2-3), 257-265. https://doi.org/10.1080/10826080601141990

 

Fischer, B., Russell, C., Sabioni, P., Van Den Brink, W., Le Foll, B., Hall, W., Rehm, J. & Room, R. (2017). Lower-risk cannabis use guidelines: A comprehensive update of evidence and recommendations. American Journal of Public Health, 107(8), e1-e12. https://doi.org/10.2105/AJPH.2017.303818

 

Fontes, M. A., Bolla, K. I., Cunha, P. J., Almeida, P. P., Jungerman, F., Laranjeira, R. R., Bressan, R. A., & Lacerda, A. L. (2011). Cannabis use before age 15 and subsequent executive functioning. The British Journal of Psychiatry : The Journal of Mental Science, 198(6), 442–447. https://doi.org/10.1192/bjp.bp.110.077479

 

Freeman, T. P., & Winstock, A. R. (2015). Examining the profile of high-potency cannabis and its association with severity of cannabis dependence. Psychological Medicine, 45(15), 3181-3189. https://doi.org/10.1017/S0033291715001178

 

Ganzer, F., Bröning, S., Kraft, S., Sack, P. M., & Thomasius, R. (2016). Weighing the evidence: A systematic review on long-term neurocognitive effects of cannabis use in abstinent adolescents and adults. Neuropsychology Review, 26(2), 186–222. https://doi.org/10.1007/s11065-016-9316-2

 

Gieringer, D. H. (2001). Cannabis “vaporization” a promising strategy for smoke harm reduction. Journal of Cannabis Therapeutics, 1(3-4), 153-170. https://doi.org/10.1300/J175v01n03_10

 

Goldschmidt, L., Richardson, G. A., Larkby, C., & Day, N. L. (2016). Early marijuana initiation: The link between prenatal marijuana exposure, early childhood behavior, and negative adult roles. Neurotoxicology and Teratology, 58, 40-45. https://doi.org/10.1016/j.ntt.2016.05.011

 

Government of Canada. (2019). Cannabis: Lower your riskshttps://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/resources/loWer-your-risks.html

 

Government of Canada. (2021). Don’t drive high. https://www.canada.ca/en/campaign/don-t-drive-high.html

 

Gray, T. R., Eiden, R. D., Leonard, K. E., Connors, G. J., Shisler, S., & Huestis, M. A. (2010). Identifying prenatal cannabis exposure and effects of concurrent tobacco exposure on neonatal growth. Clinical Chemistry, 56(9), 1442–1450. https://doi.org/10.1373/clinchem.2010.147876

 

Grotenhermen, F. (2003). Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical Pharmacokinetics, 42(4), 327-360. https://doi.org/10.2165/00003088-200342040-00003

 

Hall, W., & Degenhardt, L. (2008). Cannabis use and the risk of developing a psychotic disorder. World Psychiatry, 7(2), 68-71. https://doi.org/10.1002/j.2051-5545.2008.tb00158.x

 

Hartman, R. L., & Huestis, M. A. (2013). Cannabis effects on driving skills. Clinical Chemistry, 59(3), 478–492. https://doi.org/10.1373/clinchem.2012.194381

 

Hartogsohn, I. (2017). Constructing drug effects: A history of set and setting. Drug Science, Policy and Law, 3. https://doi.org/10.1177/2050324516683325

 

Hawk, M., Coulter, R.W. S., Egan, J. E., Fisk, S., Reuel Friedman, M., Tula, M., & Kinsky, S. (2017). Harm reduction principles for healthcare settings. Harm Reduction Journal, 14(1), 70. https://doi.org/10.1186/s12954-017-0196-4

 

Hawke, L. D., Wilkins, L., & Henderson, J. (2020). Early cannabis initiation: Substance use and mental health profiles of service-seeking youth. Journal of Adolescence, 83, 112–121. https://doi.org/10.1016/j.adolescence.2020.06.004

 

Hazekamp, A., Ruhaak, R., Zuurman, L., van Gerven, J., & Verpoorte, R. (2006). Evaluation of a vaporizing device (Volcano®) for the pulmonary administration of tetrahydrocannabinol. Journal of Pharmaceutical Sciences, 95(6), 1308-1317. https://doi.org/10.1002/jps.20574

 

Hines, L. A., Freeman, T. P., Gage, S. H., Zammit, S., Hickman, M., Cannon, M., Munafo, M., MacLeod, J., & Heron, J. (2020). Association of high-potency cannabis use with mental health and substance use in adolescence. JAMA Psychiatry, 77(10), 1044-1051. https://doi.org/10.1001/jamapsychiatry.2020.1035

 

Hosseini, S., & Oremus, M. (2019). The effect of age of initiation of cannabis use on psychosis, depression, and anxiety among youth under 25 years. The Canadian Journal of Psychiatry, 64(5), 304-312. https://doi.org/10.1177/0706743718809339

 

Hurd, Y. L., Manzoni, O. J.,Pletnikov, M. V., Lee, F. S., Bhattacharyya, S., & Melis, M. (2019). Cannabis and the developing brain: Insights into its long-lasting effects. Journal of Neuroscience, 39(42), 8250-8258. https://doi.org/10.1523/JNEUROSCI.1165-19.2019

 

Institute of Medicine (US) Committee to Assess the Science Base for Tobacco Harm Reduction, Stratton, K., Shetty, W., Wallace, R., Bondurant, S. (Eds.). (2001). Clearing the smoke: Assessing the science base for tobacco harm reduction. National Academies Press (US). https://doi.org/10.17226/10029

 

Koskinen, J., Lohonen, J., Koponen, H., Isohanni, M., & Miettunen, J. (2010). Rate of cannabis use disorders in clinical samples of patients with schizophrenia: A meta-analysis. Schizophrenia Bulletin, 36(6), 1115-1130. https://doi.org/10.1093/schbul/sbp031

 

Lau, N., Sales, P., Averill, S., Murphy, F., Sato, S. O., & Murphy, S. (2015). Responsible and controlled use: Older cannabis users and harm reduction. International Journal of Drug Policy, 26(8), 709-718. https://doi.org/10.1016/j.drugpo.2015.03.008

 

Lev-Ran, S., Roerecke, M., Le Foll, B., George, T. P., McKenzie, K., & Rehm, J. (2014). The association between cannabis use and depression: A systematic review and meta-analysis of longitudinal studies. Psychological Medicine, 44(4), 797–810. https://doi.org/10.1017/S0033291713001438

 

Li, M. C., Brady, J. E., DiMaggio, C. J., Lusardi, A. R., Tzong, K. Y., & Li, G. (2012). Marijuana use and motor vehicle crashes. Epidemiologic Reviews, 34(1), 65-72. https://doi.org/10.1093/epirev/mxr017

 

Looby, A., & Earleywine, M. (2007). Negative consequences associated with dependence in daily cannabis users. Substance Abuse Treatment, Prevention, and Policy, 2(1), 3. https://doi.org/10.1186/1747-597X-2-3

 

MacCallum, C. A., & Russo, E. B. (2018). Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine, 49, 12-19. https://doi.org/10.1016/j.ejim.2018.01.004

 

MacMaster, S. A. (2004). Harm reduction: A new perspective on substance abuse services. Social Work, 49(3), 356-363. https://doi.org/10.1093/sw/49.3.353

 

Marconi, A., Di Forti, M., Lewis, C. M., Murray, R. M., & Vassos, E. (2016). Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophrenia Bulletin, 42(5), 1262-1269. https://doi.org/10.1093/schbul/sbw003

 

Marlatt, G. A. (1996). Harm reduction: Come as you are. Addictive Behaviors, 21(6), 779-788. https://doi.org/10.1016/0306-4603(96)00042-1

 

Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M., & Lewis, G. (2007). Cannabis use and risk of psychotic or affective mental health outcomes: A systematic review. Lancet (London, England), 370(9584), 319–328. https://doi.org/10.1016/S0140-6736(07)61162-3

 

Nickel J. C. (2018). Medical marijuana for urologic chronic pelvic pain. Canadian Urological Association Journal, 12(6 Suppl 3), S181–S183. https://doi.org/10.5489/cuaj.5331

 

Noack, R., Höfler, M., & Lüken, U. (2011). Cannabis use patterns and their association with dsm-iv cannabis dependence and gender. European Addiction Research, 17(6), 321-328. https://doi.org/10.1159/000333338

 

Patton, G. C., Coffey, C., Carlin, J. B., Degenhardt, L., Lynskey, M., & Hall, W. (2002). Cannabis use and mental health in young people: Cohort study. BMJ (Clinical research ed.), 325(7374), 1195–1198. https://doi.org/10.1136/bmj.325.7374.1195

 

Pope Jr, H. G., Gruber, A. J., Hudson, J. I., Cohane, G., Huestis, M. A., & Yurgelun-Todd, D. (2003). Early-onset cannabis use and cognitive deficits: what is the nature of the association? Drug and Alcohol Dependence, 69(3), 303-310. https://doi.org/10.1016/s0376-8716(02)00334-4

 

Rogeberg, O., & Elvik, R. (2016). The effects of cannabis intoxication on motor vehicle collision revisited and revised. Addiction (Abingdon, England), 111(8), 1348–1359. https://doi.org/10.1111/add.13347

 

Ruiz-Veguilla, M., Barrigón, M. L., Hernández, L., Rubio, J. L., Gurpegui, M., Sarramea, F., Cervilla, J., Gutiérrez, B., James, A., & Ferrin, M. (2013). Dose–response effect between cannabis use and psychosis liability in a non-clinical population: Evidence from a snowball sample. Journal of Psychiatric Research, 47(8), 1036-1043. https://doi.org/10.1016/j.jpsychires.2013.03.003

 

Schlag, A. K., Hindocha, C., Zafar, R., Nutt, D. J.,  & Curran, H. V. (2021). Cannabis based medicines and cannabis dependence: A critical review of issues and evidence. Journal of Psychopharmacology, 35(7), 773-785. https://doi.org/10.1177/0269881120986393

 

Schlossarek, S., Kempkensteffen, J., Reimer, J., & Verthein, U. (2016). Psychosocial determinants of cannabis dependence: A systematic review of the literature. European Addiction Research, 22(3), 131-144. https://doi.org/10.1159/000441777

 

Schreiber, S., & Pick, C. G. (2019). Cannabis use during pregnancy: Are we at the verge of defining a “fetal cannabis spectrum disorder”? Medical hypotheses, 124, 53-55. https://doi.org/10.1016/j.mehy.2019.02.017

 

Shewan, D., Dalgarno, P., & Reith, G. (2000). Perceived risk and risk reduction among ecstasy users: the role of drug, set, and setting. International Journal of Drug Policy, 10(6), 431-453. https://doi.org/10.1016/S0955-3959(99)00038-9

 

Solomon, C. S., Solomon, G. D., & Elliott, W. (2020). The abcs of cbd: The fundamentals of cannabidiol. Primary Care Reports, 26(8). https://www.reliasmedia.com/articles/146607-the-abcs-of-cbd-the-fundamentals-of-cannaBidiol

 

Stöver, H., & Kastelic, A. (2014). 14. Drug treatment and harm reduction in prisons. Prisons and Health, 113-133. https://www.euro.who.int/__data/assets/pdf_file/0020/249203/Prisons-and-Health,-14-Drug-treatment-and-harm-reduction-in-prisons.pdf

 

Swift, J., Copeland, S., Lenton, W. (2000). Cannabis and harm reduction. Drug and Alcohol Review, 19(1), 101-112. https://doi.org/10.1080/09595230096200

 

Swift, W., Coffey, C., Carlin, J. B., Degenhardt, L., & Patton, G. C. (2008). Adolescent cannabis users at 24 years: Trajectories to regular weekly use and dependence in young adulthood. Addiction (Abingdon, England), 103(8), 1361-1370. https://doi.org/10.1111/j.1360-0443.2008.02246.x

 

Tabchi, S., & Ghosn, M. (2015). Regorafenib: start low and go slow. Targeted Oncology, 10(3), 445-447. https://doi.org/10.1007/s11523-014-0352-7

 

Tashkin, D. P., Gliederer, F., Rose, J., Change, P., Hui, K. K., Yu, J. L., & Wu, T. C. (1991). Effects of varying marijuana smoking profile on deposition of tar and absorption of co and delta-9-thc. Pharmacology, Biochemistry, and Behavior, 40(3), 651–656. https://doi.org/10.1016/0091-3057(91)90377-e

 

Van Dam, N. T., & Earleywine, M. (2010). Pulmonary function in cannabis users: Support for a clinical trial of the vaporizer. International Journal of Drug Policy, 21(6), 511-513. https://doi.org/10.1016/j.drugpo.2010.04.001

 

Willford, J. A., Chandler, L. S., Goldschmidt, L., & Day, N. L. (2010). Effects of prenatal tobacco, alcohol and marijuana exposure on processing speed, visual-motor coordination, and interhemispheric transfer. Neurotoxicology and Teratology, 32(6), 580–588. https://doi.org/10.1016/j.ntt.2010.06.004

 

Winters, K. C., & Lee, C. S. (2007;2008;). Likelihood of developing an alcohol and cannabis use disorder during youth: Association with recent use and age. Drug and Alcohol Dependence, 92(1), 239-247. https://doi.org/10.1016/j.drugalcdep.2007.08.005

 

Zacny, J. P., & Chait, L. D. (1989). Breathhold duration and response to marijuana smoke. Pharmacology, Biochemistry, and Behavior, 33(2), 481–484. https://doi.org/10.1016/0091-3057(89)90534-0

 

Zacny, J. P., & Chait, L. D. (1991). Response to marijuana as a function of potency and breathhold duration. Psychopharmacology, 103(2), 223-226. https://doi.org/10.1007/BF02244207

 

Zinberg, N. E. (1984). Drug, set, and setting: The basis for controlled intoxicant use. Yale University Press. 

 

Browne, J. (2016). How to smoke weed for maximum enjoyment: Tips for first-timers. The Cannabist. https://www.thecannabist.co/2016/10/07/how-to-smoke-weed-tips-enjoying-first-high/60322/

 

Dalgarno, P., & Shewan, D. (2005). Reducing the risks of drug use: The case for set and setting. Addiction Research & Theory, 13(3), 259-265. https://doi.org/10.1080/16066350500053562

 

Fagan, J. (1993). Set and setting revisited: Influences of alcohol and illicit drugs on the social context of violent events. Alcohol and Interpersonal Violence: Fostering Multidisciplinary Perspectives, 93, 161-191. https://books.google.ca/books?hl=en&lr=&id=ZYNHAAAAMAAJ&oi=fnd&pg=PA161&ots=hP-mvJ4t5B&sig=ghOAlNSJ5c-515ohlb9ogd7XVxY&redir_esc=y#v=onepage&q&f=false

 

Goulding, C., Shankar, A., Elliott, R., & Canniford, R. (2009). The marketplace management of illicit pleasure. Journal of Consumer Research, 35(5), 759-771. https://doi.org/10.1086/592946

 

Haijen, E. C., Kaelen, M., Roseman, L., Timmermann, C., Kettner, H., Russ, S., Nutt, D., Daws, R. E., Hampshire, A. D. G., Lorenz, R.,  & Carhart-Harris, R. L. (2018). Predicting responses to psychedelics: A prospective study. Frontiers in Pharmacology, 9, 897. https://doi.org/10.3389/fphar.2018.00897

 

Hartogsohn, I. (2017). Constructing drug effects: A history of set and setting. Drug Science, Policy and Law. https://doi.org/10.1177/2050324516683325

 

Janikian, M. (2020). Why don’t we talk about “Set and setting” when it comes to cannabis? Merry Jane. https://merryjane.com/culture/why-dont-we-talk-about-set-and-setting-when-it-comes-to-cannabis

 

Lau, N., Sales, P., Averill, S., Murphy, F., Sato, S., & Murphy, S. (2015a). A safer alternative: Cannabis substitution as harm reduction. Drug and Alcohol Review, 34(6), 654-659. https://doi.org/10.1111/dar.12275 

 

Lau, N., Sales, P., Averill, S., Murphy, F., Sato, S., & Murphy, S. (2015b). Responsible and controlled use: Older cannabis users and harm reduction. The International Journal of Drug Policy, 26(8), 709-718. https://doi.org/10.1016/j.drugpo.2015.03.008

 

Leary, T., Litwin, G. H., & Metzner, R. (1963). Reactions to psilocybin administered in a supportive environment. Journal of Nervous and Mental Disease, 137(6), 561-573. https://doi.org/10.1097/00005053-196312000-00007

 

Mason, N. L., Dolder, P. C., & Kuypers, K. P. (2020). Reported effects of psychedelic use on those with low well-being given various emotional states and social contexts. Drug Science, Policy and Law, 6, 2050324519900068. https://doi.org/10.1177/2050324519900068

 

McElrath, K., & McEvoy, K. (2002). Negative experience on ecstasy: The role of drug, set and setting. Journal of Psychoactive Drugs, 34(2), 199-208. https://doi.org/10.1080/02791072.2002.10399954

 

Metzner, R., & Leary, T. (1967). On programming psychedelic experiences. Psychedelic Review, 9, 5-19. https://maps.org/research-archive/psychedelicreview/n09/n09005met.pdf

 

Monshouwer, K., Van Laar, M., Vollebergh, W. A. (2011). Buying cannabis in ‘coffee shops’. Drug and Alcohol Review, 30(2), 148–156. https://doi.org/10.1111/j.1465-3362.2010.00268.x

 

Neitzke-Spruill, L. (2020). Race as a component of set and setting: How experiences of race can influence psychedelic experiences. Journal of Psychedelic Studies, 4(1), 51-60. https://doi.org/10.1556/2054.2019.022

 

NORML. (1996). Principles of responsible cannabis use. https://norml.org/principles/

 

Schall, M., Kemeny, A., & Maltzman, I. (1992). Factors associated with alcohol use in university students. Journal of Studies on Alcohol, 53(2), 122-136. https://doi.org/10.15288/jsa.1992.53.122

 

Schlag, A. K., Hindocha, C., Zafar, R., Nutt, D. J., & Curran, H. V. (2021). Cannabis based medicines and cannabis dependence: A critical review of issues and evidence. Journal of Psychopharmacology, 35(7), 773-785. https://doi.org/10.1177/0269881120986393

 

Shewan, D., Dalgarno, P., & Reith, G. (2000). Perceived risk and risk reduction among ecstasy users: The role of drug, set, and setting. International Journal of Drug Policy, 10(6), 431-453. https://doi.org/10.1016/S0955-3959(99)00038-9

 

Skliamis, K., Benschop, A., Liebregts, N., & Korf, D. J. (2021). Where, when and with whom: Cannabis use, settings and self-regulation rules. Contemporary Drug Problems, 48(3), 241-259. https://doi.org/10.1177/00914509211033921

 

Zinberg, N. E. (1984). Drug, set, and setting: The basis for controlled intoxicant use. Yale University Press. 

 

Cannabis Consumption Makes You Lazy and Unsuccessful

 

Barnwell, S. S., Earleywine, M., & Wilcox, R. (2006). Cannabis, motivation, and life satisfaction in an internet sample. Substance Abuse Treatment, Prevention and Policy, 1(1), 2-2. https://doi.org/10.1186/1747-597X-1-2

 

Bloomfield, M. A. P., Morgan, C. J. A., Kapur, S., Curran, H. V., & Howes, O. D. (2014). The link between dopamine function and apathy in cannabis users: An [18f]-dopa pet imaging study. Psychopharmacology, 231(11), 2251-2259. https://doi.org/10.1007/s00213-014-3523-4

 

Duncan, D. F. (1987). Lifetime prevalence of “Amotivational syndrome" among users and non users of hashish. Psychology of Addictive Behaviors, 1(2), 114-119. https://doi.org/10.1037/h0080444

 

EMCCDA. (2006). The state of the drug problems in europe. Lisbon: EMCDDA.

 

Gerard, A. (2014, May 21). Medical cannabis and the myth of amotivational syndrome. in-Training. https://in-training.org/medical-cannabis-myth-amotivational-syndrome-6905

 

Government of Canada. (2021, August 12). Canadian cannabis survey 2020: Summary. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-     data/canadian-cannabis-survey-2020-summary.html 

 

Joo, S. H., Durband, D. B., & Grable, J. (2008). The academic impact of financial stress on college students. Journal of College Student Retention: Research, Theory & Practice, 10(3), 287-305. https://doi.org/10.2190/CS.10.3.c

 

Kouri, E., Pope Jr, H. G., Yurgelun-Todd, D., & Gruber, S. (1995). Attributes of heavy vs. occasional marijuana smokers in a college population. Biological Psychiatry, 38(7), 475-481. https://doi.org/10.1016/0006-3223(94)00325-w

 

Krumrei-Mancuso, E. J., Newton, F. B., Kim, E., & Wilcox, D. (2013). Psychosocial factors predicting first-year college student success. Journal of College Student Development, 54(3), 247-266. https://doi.org/10.1353/csd.2013.0034

 

Lac, A., & Luk, J. W. (2018). Testing the amotivational syndrome: Marijuana use longitudinally predicts lower self-efficacy even after controlling for demographics, personality, and alcohol and cigarette use. Prevention Science, 19(2), 117-126. https://doi.org/10.1007/s11121-017-0811-3

 

Mattern, K. D., & Shaw, E. J. (2010). A look beyond cognitive predictors of academic success: Understanding the relationship between academic self-beliefs and outcomes. Journal of College Student Development, 51(6), 665-678. https://doi.org/10.1353/csd.2010.0017

 

Mauger, C. (2020). 'Are you high?': Marijuana advocates fume over new state-backed ads. The Detroit News. https://www.detroitnews.com/story/news/politics/2020/01/17/are-you-high-marijuana-advocates-fume-over-new-state-backed-ads/4502648002/

 

Musty, R. E., & Kaback, L. (1995). Relationships between motivation and depression in chronic marijuana users. Life Sciences, 56(23-24), 2151-2158. https://doi.org/10.1016/0024-3205(95)00202-h

 

Petrucci, A. S., LaFrance, E. M., & Cuttler, C. (2020). A comprehensive examination of the links between cannabis use and motivation. Substance Use & Misuse, 55(7), 1155-1164. https://doi.org/10.1080/10826084.2020.1729203

 

Pike, G. R., Kuh, G. D., & Massa-McKinley, R. C. (2008). First-year students' employment, engagement, and academic achievement: Untangling the relationship between work and grades. NASPA Journal, 45(4), 560-582. https://doi.org/10.2202/1949-6605.2011

 

Reilly, D., Didcott, P., Swift, W., & Hall, W. (1998). Long‐term cannabis use: Characteristics of users in an australian rural area. Addiction (Abingdon, England), 93(6), 837-846. https://doi.org/10.1046/j.1360-0443.1998.9368375.x

 

Robb, C. A., Moody, B., & Abdel-Ghany, M. (2012). College student persistence to degree: The burden of debt. Journal of College Student Retention: Research, Theory & Practice, 13(4), 431-456. https://doi.org/10.2190/CS.13.4.b

 

Suresh, K. (2011). An overview of randomization techniques: An unbiased assessment of outcome in clinical research. Journal of Human Reproductive Sciences, 4(1), 8-11. https://doi.org/10.4103/0974-1208.82352

 

van Ours, J. C., & Williams, J. (2015). Cannabis use and its effects on health, education and labor market success. Journal of Economic Surveys, 29(5), 993-1010. https://doi.org/10.1111/joes.12070

 

Wahlquist, C. (2015). ‘Stoner sloth’ anti-drug campaign gets reality check as medical experts walk away. The Guardian. https://www.theguardian.com/society/2015/dec/20/stoner-sloth-anti-drug-campaign-gets-reality-check-as-medical-experts-walk-away

 

You Won’t Get High the First Time You Try Cannabis

 

Becker, H. S. (1953). Becoming a marihuana user. American journal of Sociology, 59(3), 235-242. https://doi.org/10.1086/221326

 

Grotenhermen, F. (2003). Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical Pharmacokinetics, 42(4), 327-360. https://doi.org/10.2165/00003088-200342040-00003

 

Huestis MA. (2007). Human cannabinoid pharmacokinetics. Chemistry & Biodiversity, 4(8):1770–1804. https://doi.org/10.1002/cbdv.200790152

 

MacCallum, C. A., & Russo, E. B. (2018). Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine, 49, 12-19. https://doi.org/10.1016/j.ejim.2018.01.004

 

Novak, W. (1980). High culture: Marijuana in the lives of americans. Random House (NY).

 

Cannabis is a Gateway Drug

 

Choo, T., Roh, S., & Robinson, M. (2008). Assessing the “Gateway hypothesis” among middle and high school students in Tennessee. Journal of Drug Issues, 38(2), 467-492. https://doi.org/10.1177/002204260803800205

 

Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2006). Cannabis use and other illicit drug use: Testing the cannabis gateway hypothesis. Addiction (Abingdon, England), 101(4), 556-569. https://doi.org/10.1111/j.1360-0443.2005.01322.x

 

Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2006). Testing the cannabis gateway hypothesis: Replies to Hall, Kandel et al. and MacCoun (2006). Addiction, 101(4), 474-476. https://doi.org/10.1111/j.1360-0443.2006.01450.x

 

Fergusson, D. M., & Horwood, L. J. (2000). Does cannabis use encourage other forms of illicit drug use? Addiction (Abingdon, England), 95(4), 505-520. https://doi.org/10.1046/j.1360-0443.2000.9545053.x

 

Jorgensen, C., & Wells, J. (2021). Is marijuana really a gateway drug? A nationally representative test of the marijuana gateway hypothesis using a propensity score matching design. Journal of Experimental Criminology, 1-18. https://doi.org/10.1007/s11292-021-09464-z

 

Kandel, D. (1975). Stages in adolescent involvement in drug use. Science (New York, N.Y.), 190(4217), 912-914. https://doi.org/10.1126/science.1188374

 

Kandel, D., & Faust, R. (1975). Sequence and stages in patterns of adolescent drug use. Archives of General Psychiatry, 32(7), 923-932. https://doi.org/10.1001/archpsyc.1975.01760250115013

 

Kandel, D. B., Yamaguchi, K., & Klein, L. C. (2006). Testing the gateway hypothesis. Addiction (Abingdon, England), 101(4), 470-476. https://doi.org/10.1111/j.1360-0443.2006.01426.x

 

Maccoun, R. J. (2006). Competing accounts of the gateway effect: The field thins, but still no clear winner. Addiction, 101(4), 473-474. https://doi.org/10.1111/j.1360-0443.2006.01428.x

 

Melberg, H. O., Jones, A. M., & Bretteville-Jensen, A. L. (2010). Is cannabis a gateway to hard drugs? Empirical Economics, 38(3), 583-603. https://doi.org/10.1007/s00181-009-0280-z

 

Miller, M. L., & Hurd, Y. L. (2017). Testing the gateway hypothesis. Neuropsychopharmacology, 42(5), 985-986. https://doi.org/10.1038/npp.2016.279

 

Nkansah-Amankra, S., & Minelli, M. (2016). “Gateway hypothesis” and early drug use: Additional findings from tracking a population-based sample of adolescents to adulthood. Preventive Medicine Reports, 4, 134-141. https://doi.org/10.1016/j.pmedr.2016.05.003

 

Noel, W.M. & Wang, J. (2018). Is cannabis a gateway drug? Key findings and literature review. National Institute of Justice. https://www.ojp.gov/pdffiles1/nij/252950.pdf

 

Robinson, M. B. (2006). Why crime?:An integrated systems theory of antisocial behavior. Recording for the blind & dyslexic. Pearson/Prentice Hall. 

 

Cannabis is So Much Stronger Today Than it Was in The 1900s

 

Chandra, S., Radwan, M. M., Majumdar, C. G., Church, J. C., Freeman, T. P., & ElSohly, M. A. (2019). New trends in cannabis potency in USA and Europe during the last decade (2008–2017). European Archives of Psychiatry and Clinical Neuroscience, 269(1), 5-15. https://doi.org/10.1007/s00406-019-00983-5

 

ElSohly, M. A., Mehmedic, Z., Foster, S., Gon, C., Chandra, S., & Church, J. C. (2016). Changes in cannabis potency over the last 2 decades (1995–2014): Analysis of current data in the United States. Biological Psychiatry, 79(7), 613-619. https://doi.org/10.1016/j.biopsych.2016.01.004

 

Freeman, T. P., Groshkova, T., Cunningham, A., Sedefov, R., Griffiths, P., & Lynskey, M. T. (2019). Increasing potency and price of cannabis in Europe, 2006–16. Addiction (Abingdon, Endland),114(6), 1015-1023. https://doi.org/10.1111/add.14525

 

King, L. (2008). Understanding cannabis potency and monitoring cannabis products in europe. In S. R. Sznitman, B. Olsson, & R. Room (Eds.), A cannabis reader - global issues and local experiences (pp.239-259). European Monitoring Centre for Drugs and Drug Addiction. 

 

Le France, A. (2010). Was marijuana really less potent in the 1960s? The Atlantic. https://www.theatlantic.com/technology/archive/2015/03/was-marijuana-really-less-potent-in-the-1960s/387010/

 

McLaren, J., Swift, W., Dillon, P., & Allsop, S. (2008). Cannabis potency and contamination: a review of the literature. Addiction (Abingdon, England), 103(7), 1100-1109. https://doi.org/10.1111/j.1360-0443.2008.02230.x

 

Mehmedic, Z., Chandra, S., Slade, D., Denham, H., Foster, S., Patel, A. S., Ross, S. A., Khan, I. A., & ElSohly, M. A. (2010). Potency trends of Δ9‐THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008. Journal of Forensic Sciences, 55(5), 1209-1217. https://doi.org/10.1111/j.1556-4029.2010.01441.x

 

The Thistle. (2000). Myths about marijuana. https://www.mit.edu/~thistle/v13/2/myths.html

 

Cannabis Will Make You a Criminal

 

Adda, J., McConnell, B., & Rasul, I. (2014). Crime and the depenalization of cannabis possession: Evidence from a policing experiment. Journal of Political Economy,122(5), 1130-1202. https://doi.org/10.1086/676932

 

Boyd, S. (2010). Reefer madness and beyond. In M. Deflem (Ed.), Popular culture, crime and social control (pp.3-24). Emerald Group Publishing Limited. https://doi.org/10.1108/S1521-6136(2010)0000014004

 

Brinkman, J., & Mok-Lamme, D. (2019). Not in my backyard? Not so fast. The effect of marijuana legalization on neighborhood crime. Regional Science and Urban Economics, 78, 103460. https://doi.org/10.1016/j.regsciurbeco.2019.103460

 

Dellazizzo, L., Potvin, S., Athanassiou, M., & Dumais, A. (2020). Violence and cannabis use: A focused review of a forgotten aspect in the era of liberalizing cannabis. Frontiers in Psychiatry, 11, 567887-567887. https://doi.org/10.3389/fpsyt.2020.567887

 

Denson, T. F., & Earleywine, M. (2008). Self-reported use of alcohol, marijuana, and hard drugs and aggression: A structural equation modeling analysis of an internet survey of long term marijuana users. Journal of Aggression, Maltreatment and Trauma, 16(2), 164-180. https://doi.org/10.1080/10926770801921469

 

Drug Enforcement Administration Museum & Visitors Center (n.d.). Harry jacob anslinger 1930s. https://deamuseum.org/anslinger/in-charge/

 

Freisthler, B., Gaidus, A., Tam, C., Ponicki, W. R., & Gruenewald, P. J. (2017). From medical to recreational marijuana sales: Marijuana outlets and crime in an era of changing marijuana legislation. The Journal of Primary Prevention, 38(3), 249–263. https://doi.org/10.1007/s10935-017-0472-9

 

Green, K. M., Doherty, E. E., Stuart, E. A., & Ensminger, M. E. (2010). Does heavy adolescent marijuana use lead to criminal involvement in adulthood? Evidence from a multiwave longitudinal study of urban african americans. Drug and Alcohol Dependence, 112(1-2), 117-125. https://doi.org/10.1016/j.drugalcdep.2010.05.018

 

Huber III, A., Newman, R., & LaFave, D. (2016). Cannabis control and crime: Medicinal use, depenalization and the war on drugs. The BE Journal of Economic Analysis & Policy, 16(4). https://doi.org/10.1515/bejeap-2015-0167

 

Ostrowsky, M. K. (2011). Does marijuana use lead to aggression and violent behavior? Journal of Drug Education, 41(4), 369-389. https://doi.org/10.2190/DE.41.4.c

 

Pacula, R. L., & Kilmer, B. (2003). Marijuana and crime: Is there a connection beyond prohibition? National Bureau of Economic Research. https://www.nber.org/papers/w10046

 

Pedersen, W., & Skardhamar, T. (2010). Cannabis and crime: findings from a longitudinal study. Addiction (Abingdon, England), 105(1), 109-118. https://doi.org/10.1111/j.1360-0443.2009.02719.x

 

Riggs, N. R., Chou, C., & Pentz, M. A. (2009). Protecting against intergenerational problem behavior: Mediational effects of prevented marijuana use on second-generation parent child relationships and child impulsivity. Drug and Alcohol Dependence, 100(1-2), 153-160. https://doi.org/10.1016/j.drugalcdep.2008.10.003

 

Solomon, R. (2020). Racism and its effect on cannabis research. Cannabis and Cannabinoid Research, 5(1), 2-5. https://doi.org/10.1089/can.2019.0063

 

Stringer, R. J., & Maggard, S. R. (2016). Reefer madness to marijuana legalization: Media exposure and american attitudes toward marijuana (1975-2012). Journal of Drug Issues, 46(4), 428-445. https://doi.org/10.1177/0022042616659762

 

Weed Maps. (n.d.). Does smoking weed kill brain cells? https://weedmaps.com/learn/cannabis-and-your-body/does-smoking-weed-kill-brain-cells

 

Wei, E. H., Loeber, R., & White, H. R. (2004). Teasing apart the developmental associations between alcohol and marijuana use and violence. Journal of Contemporary Criminal Justice, 20(2), 166–183.https://doi.org/10.1177/1043986204263777

 

Smoking Cannabis Kills Brain Cells

 

Burggren, A. C., Shirazi, A., Ginder, N., & London, E. D. (2019). Cannabis effects on brain structure, function, and cognition: Considerations for medical uses of cannabis and its derivatives. The American Journal of Drug and Alcohol Abuse, 45(6), 563-579. https://doi.org/10.1080/00952990.2019.1634086

 

Chang, L., Yakupov, R., Cloak, C., & Ernst, T. (2006). Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain: A Journal of Neurology, 129(Pt 5), 1096-1112. https://doi.org/10.1093/brain/awl064

 

Chen, Y., & Buck, J. (2000). Cannabinoids protect cells from oxidative cell death: A receptor-independent mechanism. Journal of Pharmacology and Experimental Therapeutics, 293(3), 807-812. https://jpet.aspetjournals.org/content/293/3/807

 

Chu, Y. W. L., & Gershenson, S. (2018). High times: The effect of medical marijuana laws on student time use. Economics of Education Review, 66, 142-153. https://doi.org/10.1016/j.econedurev.2018.08.003

 

Colizzi, M., Tosato, S., & Ruggeri, M. (2020). Cannabis and cognition: Connecting the dots towards the understanding of the relationship. Brain Sciences, 10(3), 133. https://doi.org/10.3390/brainsci10030133

 

Cousijn, J., Wiers, R. W., Ridderinkhof, K. R., van den Brink, W., Veltman, D. J., & Goudriaan, A. E. (2014). Effect of baseline cannabis use and working‐memory network function on changes in cannabis use in heavy cannabis users: A prospective fMRI study. Human Brain Mapping, 35(5), 2470-2482. https://doi.org/10.1002/hbm.22342

 

Fishbein, M., Gov, S., Assaf, F., Gafni, M., Keren, O., & Sarne, Y. (2012). Long-term behavioral and biochemical effects of an ultra-low dose of Δ 9-tetrahydrocannabinol (THC): Neuroprotection and ERK signaling. Experimental Brain Research, 221(4), 437-448. https://doi.org/10.1007/s00221-012-3186-5

 

Harvey, M. A., Sellman, J. D., Porter, R. J., & Frampton, C. M. (2007). The relationship between non-acute adolescent cannabis use and cognition. Drug and Alcohol Review, 26(3), 309-319. https://doi.org/10.1080/09595230701247772

 

Heath, R. G. (1973). Marijuana: Effects on deep and surface electroencephalograms of rhesus monkeys. Neuropharmacology, 12(1), 1-14. https://doi.org/10.1016/0028-3908(73)90126-3

 

Jager, G., Kahn, R. S., Van Den Brink, W., Van Ree, J.,M., & Ramsey, N. F. (2006). Long-term effects of frequent cannabis use on working memory and attention: An fMRI 22 study. Psychopharmacology, 185(3), 358-368. https://doi.org/10.1007/s00213-005-0298-7

 

Jiang, W., Zhang, Y., Xiao, L., Van Cleemput, J., Ji, S. P., Bai, G., & Zhang, X. (2005). Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic-and antidepressant-like effects. The Journal of Clinical Investigation, 115(11), 3104-3116. https://doi.org/10.1172/JCI25509

 

Kanayama, G., Rogowska, J., Pope, H. G., Gruber, S. A., & Yurgelun-Todd, D. A. (2004). Spatial working memory in heavy cannabis users: A functional magnetic resonance imaging study. Psychopharmacology, 176(3), 239-247. https://doi.org/10.1007/s00213-004-1885-8

 

Loreto, M. (2021). Does smoking weed kill a person’s brain cells? The Growth Op. nabis-news/does-smoking-weed-kill-a-persons-brain-cells

 

Mechoulam, R., Panikashvili, D., & Shohami, E. (2002). Cannabinoids and brain injury: Therapeutic implications. Trends in Molecular Medicine, 8(2), 58-61. https://doi.org/10.1016/s1471-4914(02)02276-1

 

Moreau, J. (2016). “I learned it by watching you!” The partnership for a drug-free america and the attack on “Responsible use” education in the 1980s. Journal of Social History, 49(3), 710-737. https://doi.org/10.1093/jsh/shv062

 

O’Neal, C. M., Baker, C. M., Glenn, C. A., Conner, A. K., & Sughrue, M. E. (2017). Dr. robert g. heath: A controversial figure in the history of deep brain stimulation. Neurosurgical Focus, 43(3), E12. https://doi.org/10.3171/2017.6.FOCUS17252

 

Pope Jr, H. G., Gruber, A. J., Hudson, J. I., Cohane, G., Huestis, M. A., & Yurgelun-Todd, D. (2003). Early-onset cannabis use and cognitive deficits: What is the nature of the association? Drug and Alcohol Dependence, 69(3), 303-310. https://doi.org/10.1016/s0376-8716(02)00334-4

 

Schoeler, T., Kambeitz, J., Behlke, I., Murray, R., & Bhattacharyya, S. (2016). The effects of cannabis on memory function in users with and without a psychotic disorder: Findings from a combined meta-analysis. Psychological Medicine, 46(1), 177-188. https://doi.org/10.1017/S0033291715001646

 

Schreiner, A. M., & Dunn, M. E. (2012). Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: A meta-analysis. Experimental and Clinical Psychopharmacology, 20(5), 420-429. https://doi.org/10.1037/a0029117

 

The Thistle. (2000). Myths about marijuana. https://www.mit.edu/~thistle/v13/2/myths.html

 

Yanes, J. A., Riedel, M. C., Ray, K. L., Kirkland, A. E., Bird, R. T., Boeving, E. R., Reid, M. A., Gonzalez, R., Robinson, J. L., Laird, A. R., & Sutherland, M. T. (2018). Neuroimaging meta-analysis of cannabis use studies reveals convergent functional alterations in brain regions supporting cognitive control and reward processing. Journal of Psychopharmacology (Oxford, England), 32(3), 283-295. https://doi.org/10.1177/0269881117744995

 

You Can Drive Better When You’re High

 

Asbridge, M., Hayden, J. A., & Cartwright, J. L. (2012). Acute cannabis consumption and motor vehicle collision risk: Systematic review of observational studies and meta-analysis. BMJ (Online), 344, e536. https://doi.org/10.1136/bmj.e536

 

Asbridge, M., Mann, R., Cusimano, M. D., Trayling, C., Roerecke, M., Tallon, J. M., Whipp, A., & Rehm, J. (2014). Cannabis and traffic collision risk: Findings from a case-crossover study of injured drivers presenting to emergency departments. International Journal of Public Health, 59(2), 395-404. https://doi.org/10.1007/s00038-013-0512-z

 

Bédard, M., Dubois, S., & Weaver, B. (2007). The impact of cannabis on driving. Canadian Journal of Public Health, 98(1), 6-11. https://doi.org/10.1007/BF03405376

 

Downey, L. A., King, R., Papafotiou, K., Swann, P., Ogden, E., Boorman, M., & Stough, C. (2013). The effects of cannabis and alcohol on simulated driving: Influences of dose and experience. Accident; analysis and prevention, 50, 879–886. https://doi.org/10.1016/j.aap.2012.07.016

 

Fischer, B., Russell, C., Sabioni, P., Van Den Brink, W., Le Foll, B., Hall, W., Rehm, J., & Room, R. (2017). Lower-risk cannabis use guidelines: A comprehensive update of evidence and recommendations. American Journal of Public Health, 107(8), E1-E12. https://doi.org/10.2105/AJPH.2017.303818

 

Government of Canada. (2020). Canadian Cannabis Survey 2020: Summary. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/canadian-cannabis-survey-2020-summary.html#a4

 

Government of Canada. (2021). Don’t drive high. https://www.canada.ca/en/campaign/don-t-drive-high.html

 

Hartman, R. L., & Huestis, M. A. (2013). Cannabis effects on driving skills. Clinical Chemistry, 59(3), 478–492. https://doi.org/10.1373/clinchem.2012.194381

 

Li, M. C., Brady, J. E., DiMaggio, C. J., Lusardi, A. R., Tzong, K. Y., & Li, G. (2012). Marijuana use and motor vehicle crashes. Epidemiologic Reviews, 34(1), 65-72. https://doi.org/10.1093/epirev/mxr017

 

McCartney, D., Arkell, T. R., Irwin, C., & McGregor, I. S. (2021). Determining the magnitude  and duration of acute [DELTA].sup.9-tetrahydrocannabinol -induced driving and  cognitive impairment: A systematic and meta-analysis review. Neuroscience and  Biobehavioral Reviews, 126, 175. https://doi.org/10.1016/j.neubiorev.2021.01.003 

 

Ramaekers, J. G., Robbe, H. W., & O'Hanlon, J. F. (2000). Marijuana, alcohol and actual driving performance. Human Psychopharmacology, 15(7), 551–558. https://doi.org/10.1002/1099-1077(200010)15:7<551::AID-HUP236>3.0.CO;2-P

 

Rogeberg, O., & Elvik, R. (2016). The effects of cannabis intoxication on motor vehicle collision revisited and revised. Addiction (Abingdon, England), 111(8), 1348–1359. https://doi.org/10.1111/add.13347

 

Swift, W., Copeland, J., Lenton, S. (2000). Cannabis and harm reduction. Drug and Alcohol Review, 19(1), 101-112. https://doi.org/10.1080/09595230096200

 

It’s Natural So it’s Harmless

 

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596

 

Budney, A. J., Hughes, J. R., Moore, B. A., & Vandrey, R. (2004). Review of the validity and significance of cannabis withdrawal syndrome. The American Journal of Psychiatry, 161(11), 1967-1977. https://doi.org/10.1176/appi.ajp.161.11.1967

 

Casadio, P., Fernandes, C., Murray, R. M., & Di Forti, M. (2011). Cannabis use in young people: The risk for schizophrenia. Neuroscience and Biobehavioral Reviews, 35(8), 1779-1787. https://doi.org/10.1016/j.neubiorev.2011.04.007

 

Chang, L., Yakupov, R., Cloak, C., & Ernst, T. (2006). Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation. Brain: A Journal of Neurology, 129(Pt 5), 1096-1112. https://doi.org/10.1093/brain/awl064

 

Colizzi, M., Tosato, S., & Ruggeri, M. (2020). Cannabis and cognition: Connecting the dots towards the understanding of the relationship. Brain Sciences, 10(3), 133. https://doi.org/10.3390/brainsci10030133

 

Joshi, M., Joshi, A., & Bartter, T. (2014). Marijuana and lung diseases. Current Opinion in Pulmonary Medicine, 20(2), 173-179. https://doi.org/10.1097/MCP.0000000000000026

 

Moir, D., Rickert, W. S., Levasseur, G., Larose, Y., Maertens, R., White, P., & Desjardins, S. (2008). A comparison of mainstream and sidestream marijuana and tobacco cigarette smoke produced under two machine smoking conditions. Chemical Research in Toxicology, 21(2), 494-502. https://doi.org/10.1021/tx700275p

 

Moore, T. H., Zammit, S., Lingford-Hughes, A., Barnes, T. R., Jones, P. B., Burke, M., & Lewis, G. (2007). Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review. Lancet (London, England), 370(9584), 319-328. https://doi.org/10.1016/S0140-6736(07)61162-3

 

Patel, J., & Marwaha, R. (2021). Cannabis use disorder. StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK538131/ 

 

Salas-Wright, C. P., Carbone, J. T., Holzer, K. J., & Vaughn, M. G. (2019). Prevalence and correlates of cannabis poisoning diagnosis in a national emergency department sample. Drug and Alcohol Dependence, 204, 107564-107564. https://doi.org/10.1016/j.drugalcdep.2019.107564 

 

Schoeler, T., Kambeitz, J., Behlke, I., Murray, R., & Bhattacharyya, S. (2016). The effects of cannabis on memory function in users with and without a psychotic disorder: Findings from a combined meta-analysis. Psychological Medicine, 46(1), 177-188. https://doi.org/10.1017/S0033291715001646

 

Schreiner, A. M., & Dunn, M. E. (2012). Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: A meta-analysis. Experimental and Clinical Psychopharmacology, 20(5), 420-429. https://doi.org/10.1037/a0029117

 

Yanes, J. A., Riedel, M. C., Ray, K. L., Kirkland, A. E., Bird, R. T., Boeving, E. R., Reid, M. A., Gonzalez, R., Robinson, J. L., Laird, A. R., & Sutherland, M. T. (2018). Neuroimaging meta-analysis of cannabis use studies reveals convergent functional alterations in brain regions supporting cognitive control and reward processing. Journal of Psychopharmacology (Oxford, England), 32(3), 283-295. https://doi.org/10.1177/0269881117744995

 

If You Hold the Smoke in Longer You Get More High 

 

Azorlosa, J. L., Greenwald, M. K., & Stitzer, M. L. (1995). Marijuana smoking: Effects of varying puff volume and breathhold duration. Journal of Pharmacology and Experimental Therapeutics, 272(2), 560-569. https://pubmed.ncbi.nlm.nih.gov/7853169/

 

Farris, S. G., & Metrik, J. (2016). Acute effects of cannabis on breath-holding duration. Experimental and Clinical Psychopharmacology, 24(4), 305–312. https://doi.org/10.1037/pha0000075

 

Fischer, B., Russell, C., Sabioni, P., Van Den Brink, W., Le Foll, B., Hall, W., Rehm, J. & Room, R. (2017). Lower-risk cannabis use guidelines: A comprehensive update of evidence and recommendations. American Journal of Public Health, 107(8), e1-e12. https://doi.org/10.2105/AJPH.2017.303818

 

McClure, E. A., Stitzer, M. L., & Vandrey, R. (2012). Characterizing smoking topography of cannabis in heavy users. Psychopharmacology, 220(2), 309-318. https://doi.org/10.1007/s00213-011-2480-4 

 

Zacny, J. P., & Chait, L. D. (1989). Breathhold duration and response to marijuana smoke. Pharmacology, Biochemistry, and Behavior, 33(2), 481–484. https://doi.org/10.1016/0091-3057(89)90534-0

 

Zacny, J. P., & Chait, L. D. (1991). Response to marijuana as a function of potency and breathhold duration. Psychopharmacology, 103(2), 223-226. https://doi.org/10.1007/BF02244207

 

If You Eat Raw Cannabis, You Will Get High

 

Blake, A., & Nahtigal, I. (2019). The evolving landscape of cannabis edibles. Current Opinion in Food Science, 28, 25-31. https://doi.org/10.1016/j.cofs.2019.03.009

 

Hädener, M., Vieten, S., Weinmann, W., & Mahler, H. (2019). A preliminary investigation of lung availability of cannabinoids by smoking marijuana or dabbing BHO and decarboxylation rate of THC-and CBD-acids. Forensic Science International, 295, 207-212. https://doi.org/10.1016/j.forsciint.2018.12.021

 

Moreno, T., Dyer, P., & Tallon, S. (2020). Cannabinoid decarboxylation: A comparative kinetic study. Industrial & Engineering Chemistry Research, 59(46), 20307-20315. https://doi.org/10.1021/acs.iecr.0c03791

 

Nuapia, Y., Maraba, K., Tutu, H., Chimuka, L., & Cukrowska, E. (2021). In situ decarboxylation-pressurized hot water extraction for selective extraction of cannabinoids from cannabis sativa. Chemometric Approach. Molecules, 26(11), 3343. https://doi.org/10.3390/molecules26113343

 

Wang, M., Wang, Y., Avula, B., Radwan, M. M., Wanas, A. S., van Antwerp, J., Parcher, J. F., ElSohly, M. A., & Khan, I. A. (2016). Decarboxylation study of acidic cannabinoids: A novel approach using ultra-high-performance supercritical fluid chromatography/photodiode array-mass spectrometry. Cannabis and Cannabinoid Research, 1(1), 262-271. https://doi.org/10.1089/can.2016.0020

 

Having Cannabis in Your System (ex. Blood Test) Means You are High

 

Odell, M. S., Frei, M. Y., Gerostamoulos, D., Chu, M., & Lubman, D. I. (2015). Residual cannabis levels in blood, urine and oral fluid following heavy cannabis use. Forensic  Science International, 249, 173-180. https://doi.org/10.1016/j.forsciint.2015.01.026 

 

You Cannot Overdose on Cannabis

 

Salas-Wright, C. P., Carbone, J. T., Holzer, K. J., & Vaughn, M. G. (2019). Prevalence and correlates of cannabis poisoning diagnosis in a national emergency department sample. Drug and Alcohol Dependence, 204, 107564-107564. https://doi.org/10.1016/j.drugalcdep.2019.107564 

 

THC Content is The Most Important Data Point

 

McLaren, J., Swift, W., Dillon, P., & Allsop, S. (2008). Cannabis potency and contamination: A review of the literature. Addiction (Abingdon, England), 103(7), 1100-1109.  https://doi.org/10.1111/j.1360-0443.2008.02230.x 

 

Wang, M., Wang, Y., Avula, B., Radwan, M. M., Wanas, A. S., van Antwerp, J., Parcher, J. F., ElSohly, M. A., & Khan, I. A. (2016). Decarboxylation study of acidic cannabinoids: A novel approach using ultra-high-performance supercritical fluid chromatography/photodiode array-mass spectrometry. Cannabis and Cannabinoid Research, 1(1), 262-271. https://doi.org/10.1089/can.2016.0020

 

Car Accidents Will Go Up After Legalization

 

Aydelotte, J. D., Brown, L. H., Luftman, K. M., Mardock, A. L., Teixeira, P. G. R., Coopwood, B., & Brown, C. V. R. (2017). Crash fatality rates after recreational marijuana legalization in washington and colorado. American Journal of Public Health (1971), 107(8), 1329-1331. https://doi.org/10.2105/AJPH.2017.303848  

 

Callaghan, R. C., Sanches, M., Vander Heiden, J., Asbridge, M., Stockwell, T., Macdonald, S., Peterman, B. H., & Kish, S. J. (2021). Canada’s cannabis legalization and drivers’  traffic-injury presentations to emergency departments in ontario and alberta, 2015-2019. Drug and Alcohol Dependence, 228, 109008-109008. https://doi.org/10.1016/j.drugalcdep.2021.109008 

 

Cannabis is Worse Than Alcohol

 

Nutt, D. J., Prof, King, L. A., PhD, Phillips, L. D., PhD, on behalf of the Independent Scientific Committee on Drugs, & Independent Scientific Committee on Drugs. (2010). Drug harms in the uk: A multicriteria decision analysis. The Lancet (British Edition), 376(9752), 1558-1565. https://doi.org/10.1016/S0140-6736(10)61462-6 

 

Weissenborn, R., & Nutt, D. J. (2012). Popular intoxicants: What lessons can be learned from the last 40 years of alcohol and cannabis regulation? Journal of Psychopharmacology (Oxford), 26(2), 213-220. https://doi.org/10.1177/0269881111414751 

 

Cannabis Has Killed More People Than Alcohol

 

CDC. (2021, January 14). Deaths from excessive alcohol use in the united states. https://www.cdc.gov/alcohol/features/excessive-alcohol-deaths.html 

 

Smoking Cannabis is Just as Bad as Smoking Cigarettes 

 

Barnwell, S. S., Earleywine, M., & Wilcox, R. (2006). Cannabis, motivation, and life satisfaction in an internet sample. Substance Abuse Treatment, Prevention and Policy, 1(1), 2-2. https://doi.org/10.1186/1747-597X-1-2 

 

You Cannot be Addicted to Cannabis

 

Behrendt, S., Wittchen, H., Höfler, M., Lieb, R., & Beesdo, K. (2008;2009;). Transitions from first substance use to substance use disorders in adolescence: Is early onset associated with a rapid escalation? Drug and Alcohol Dependence, 99(1), 68-78. https://doi.org/10.1016/j.drugalcdep.2008.06.014  

 

Government of Canada. (2021, July 2). Addiction to cannabis. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/health-effects/addiction.html  

 

Lopez-Quintero, C., Cobos, Jose Perez de los, Hasin, D. S., Okuda, M., Wang, S., Grant, B. F., & Blanco, C. (2010;2011). Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: Results of the national epidemiological survey on alcohol and related conditions (nesarc). Drug and Alcohol Dependence, 115(1), 120-130. https://doi.org/10.1016/j.drugalcdep.2010.11.004 

 

Patel, J., & Marwaha, R. (2021). Cannabis use disorder. StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK538131/ 

 

You Can Become Addicted After One Try

 

Behrendt, S., Wittchen, H., Höfler, M., Lieb, R., & Beesdo, K. (2008;2009;). Transitions from first substance use to substance use disorders in adolescence: Is early onset associated with a rapid escalation? Drug and Alcohol Dependence, 99(1), 68-78. https://doi.org/10.1016/j.drugalcdep.2008.06.014 

 

There is No Benefit/Effect of Consuming CBD

 

DiLonardo, M., J. (2019). Cbd vs. thc: What’s the difference? WEbMEd. https://www.webmd.com/pain-management/cbd-thc-difference

 

Fletcher, J. (2019). A comparison of cbd and thc. Medical News Today. https://www.medicalnewstoday.com/articles/325871

 

Rexaline, S. (2019, March 7). Cbd vs. thc: The science behind most popular cannabinoids. Benzinga. https://www.benzinga.com/markets/cannabis/19/03/13312269/cbd-vs-thc-the-science-behind-the-most-popular-cannabinoids?utm_sq=g0v89su8hc&utm_source=Twitter&utm_medium=social&utm_campaign=ParkAmerican&utm_content=NewsArticles 

 

Sativa/Indica Describe the Effects of Cannabis, Instead of the Physical Plant Shape

 

Indica vs. sativa: Know your cannabis subspecies. (2020). Crescolabs. https://www.crescolabs.com/indica-vs-sativa/

 

Dangers of High THC Potency Cannabis

 

Drennan, M.L., Karoly, H.C., Bryan, A.D., Hutchison, K.E., Bidwell, L.C. (2021). Acute objective and subjective intoxication effects of legal-market high potency thc-dominant versus cbd-dominant cannabis concentrates. Scientific Reports (Nature Publisher Group), 11(1) https://doi.org/10.1038/s41598-021-01128-2

 

People with a Personal or Family History of Psychosis Should Not Consume Cannabis

 

Caspi, A., Moffitt, T.E., Cannon, M., McClay, J., Murray, R., Harrington, H., Taylor, A., Arseneault, L., Williams, B., Braithwaite, A., Poulton, R., Craig, I.W. (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-o-methyltransferase gene: Longitudinal evidence of a gene x environment interaction. Biological Psychiatry, 57(10), 1117-1127. https://doi.org/10.1016/j.biopsych.2005.01.026

 

Consuming the Stems will Make You Sick/Give You a Headache

 

Jin, D., Dai, K., Xie, Z., Chen, J. (2020). Secondary metabolites profiled in cannabis inflorescences, leaves, stem barks, and roots for medicinal purposes. Scientific Reports, 10, 3309. https://doi.org/10.1038/s41598-020-60172-6

 

There is Justifiable Cause to Disproportionately Incarcerate People of Colour

 

Valleriani, J., Lavalley, J., & McNeil, R. (2018). A missed opportunity? Cannabis legalization and reparations in canada. Canadian Journal of Public Health, 109(5-6), 745-747. https://doi.org/10.17269/s41997-018-0121-y

 

It is Fine to Drive While Smoking or Just After You Smoke

 

McCartney, D., Arkell, T. R., Irwin, C., & McGregor, I. S. (2021). Determining the magnitude and duration of acute [DELTA].sup.9-tetrahydrocannabinol -induced driving and cognitive impairment: A systematic and meta-analysis review. Neuroscience and Biobehavioral Reviews, 126, 175. https://doi.org/10.1016/j.neubiorev.2021.01.003

 

Pearlson, G. D., Stevens, M. C., & D’Souza, D. C. (2021). Cannabis and driving. Frontiers in Psychiatry, 12, 689444-689444. https://doi.org/10.3389/fpsyt.2021.689444                         

 

Wang, G. S. (2021). Cannabis (marijuana): Acute intoxication. UpToDatehttps://www.uptodate.com/contents/cannabis-marijuana-acuteintoxication#:~:text=Inhaled%20marijuana%20%E2%80%93%20After%20inhalation%20of,lasting%20up%20to%20four%20hours

 

Cannabis Users are Drug Addicts

 

Government of Canada. (2021, July 2). Addiction to cannabis. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/healtheffects/addiction.html 

 

Cannabis and Anesthesia

 

Imasogie, N., Rose, R. V., & Wilson, A. (2021). High quantities: Evaluating the association between cannabis use and propofol anesthesia during endoscopy. PloS One, 16(3), e0248062-e0248062. https://doi.org/10.1371/journal.pone.0248062  

 

Sadighi, T., & Londahl-Ramsey, V. (2021). Cannabis use: Change in screening for primary care preoperative clearance. Journal for Nurse Practitioners, 17(7), 819-822. https://doi.org/10.1016/j.nurpra.2021.02.021 

 

Cannabis Harms the Developing Brain

 

Shen, H. (2020). News feature: Cannabis and the adolescent brain. PNAS, 117(1), 7-11. https://doi.org/10.1073/pnas.1920325116

 

Cannabis Gives You the Munchies

 

Hull, M. (2019). The science behind munchies: cannabis and your appetite. Examine. https://examine.com/nutrition/cannabis-munchies/ 

 

Roberts, C. A., Jager, G., Christiansen, P., & Kirkham, T. C. (2019). Exploring the munchies: An online survey of users’ experiences of cannabis effects on appetite and the development of a cannabinoid eating experience questionnaire. Journal of Psychopharmacology (Oxford), 33(9), 1149-1159. https://doi.org/10.1177/0269881119862526 

 

Smoking Makes You Hallucinate

 

Barrett, F. S., Schlienz, N. J., Lembeck, N., Waqas, M., & Vandrey, R. (2018). “Hallucinations” following acute cannabis dosing: A case report and comparison to other hallucinogenic drugs. Cannabis and Cannabinoid Research, 3(1), 85-93. https://doi.org/10.1089/can.2017.0052 

 

You Can Get High from Second-Hand Smoke

 

Herrmann, E. S., Cone, E. J., Mitchell, J. M., Bigelow, G. E., LoDico, C., Flegel, R., & Vandrey, R. (2015). Non-smoker exposure to secondhand cannabis smoke II: Effect of room ventilation on the physiological, subjective, and behavioral/cognitive effects. Drug and Alcohol Dependence, 151, 194-202. https://doi.org/10.1016/j.drugalcdep.2015.03.019

 

Abrams, D. I., Vizoso, H. P., Shade, S. B., Jay, C., Kelly, M. E., & Benowitz, N. L. (2007). Vaporization as a smokeless cannabis delivery system: a pilot study. Clinical Pharmacology & Therapeutics, 82(5), 572-578. https://doi.org/10.1038/sj.clpt.6100200

 

Adams, I. B., & Martin, B. R. (1996). Cannabis: Pharmacology and toxicology in animals and humans. Addiction (Abingdon, England), 91(11), 1585-1614. https://doi.org/10.1046/j.1360-0443.1996.911115852.x 

 

Alger, B. E. (2013). Getting high on the endocannabinoid system. Cerebrum : The Dana Forum on Brain Science,  2013, 14. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3997295/

 

Allen, J. A., Davis, K. C., Duke, J. C., Nonnemaker, J. M., Bradfield, B. R., & Farrelly, M. C. (2017). New product trial, use of edibles, and unexpected highs among marijuana and hashish users in colorado. Drug and Alcohol Dependence, 176, 44-47. https://doi.org/10.1016/j.drugalcdep.2017.03.006 

 

Arboleda, M. F., Prosk, E., Cyr, C., Gamaoun, R., & Vigano, A. (2020). Medical cannabis in supportive cancer care: Lessons from Canada. Supportive Care in Cancer: Official Journal of Multinational Association of Supportive Care in Cancer, 28(7), 2999-3001. https://doi.org/10.1007/s00520-020-05403-2

 

Aston, E. R., Scott, B., & Farris, S. G. (2019). A qualitative analysis of cannabis vaporization among medical users. Experimental and Clinical Psychopharmacology, 27(4), 301-308. https://doi.org/10.1037/pha0000279  

 

Azofeifa, A., Mattson, M. E., Schauer, G., McAfee, T., Grant, A., & Lyerla, R. (2016). National estimates of marijuana use and related indicators — national survey on drug use and health, united states, 2002–2014. Morbidity and mortality weekly report. Surveillance summaries (Washington, D.C.: 2002), 65(11), 1-28. https://doi.org/10.15585/mmwr.ss6511a1 

 

Baron, E. P. (2015). Comprehensive review of medicinal marijuana, cannabinoids, and therapeutic implications in medicine and headache: What a long strange trip it's been. Headache, 55(6), 885-916. https://doi.org/10.1111/head.12570 

 

Barrus, D. G., Capogrossi, K. L., Cates, S. C., Gourdet, C. K., Peiper, N. C., Novak, S. P., Lefever, T. W., & Wiley, J. L. (2016). Tasty thc: Promises and challenges of cannabis edibles. Methods report (RTI Press), 2016, 10.3768/rtipress.2016.op.0035.1611. https://doi.org/10.3768/rtipress.2016.op.0035.1611 

 

Benjamin, D. M., & Fossler, M. J. (2016). Edible cannabis products: it is time for FDA oversight. The Journal of Clinical Pharmacology, 56(9), 1045-1047. https://doi.org/10.1002/jcph.778

 

Benzinga. (2018, March 30). Smoking is just one way to use marijuana: An introduction to vaporizers, edibles, oils, tinctures, dabs and other cannabis products. https://www.benzinga.com/general/biotech/18/03/11035855/smoking-is-just-one-way-to-use-marijuana-an-introduction-to-vaporizer

 

Birnbaum, A. K., Karanam, A., Marino, S. E., Barkley, C. M., Remmel, R. P., Roslawski, M., Gramling‐Aden, M., & Leppik, I. E. (2019). Food effect on pharmacokinetics of cannabidiol oral capsules in adult patients with refractory epilepsy. Epilepsia (Copenhagen), 60(8), 1586-1592. https://doi.org/10.1111/epi.16093 

 

Bjorge, P. (2020, March 4). Cannabis tinctures 101: How to make, consume, and dose them. Leafly. https://www.leafly.ca/news/cannabis-101/cannabis-tinctures-101-what-are-they-how-to-make-them-and-how-to 

 

Blake, A., & Nahtigal, I. (2019). The evolving landscape of cannabis edibles. Current Opinion in Food Science, 28, 25-31. https://doi.org/10.1016/j.cofs.2019.03.009 

 

Bloor, R. N., Wang, T. S., Spanel, P., & Smith, D. (2008). Ammonia release from heated ‘street’ cannabis leaf and its potential toxic effects on cannabis users. Addiction (Abingdon, England), 103(10), 1671-1677. https://doi.org/10.1111/j.1360-0443.2008.02281.x

 

Borodovsky, J. T., Crosier, B. S., Lee, D. C., Sargent, J. D., & Budney, A. J. (2016). Smoking, vaping, eating: Is legalization impacting the way people use cannabis? The International Journal of Drug Policy, 36, 141-147. https://doi.org/10.1016/j.drugpo.2016.02.022 

 

Borodovsky, J. T., Lee, D. C., Crosier, B. S., Gabrielli, J. L., Sargent, J. D., & Budney, A. J. (2017). U.S. cannabis legalization and use of vaping and edible products among youth. Drug and alcohol dependence, 177, 299-306. https://doi.org/10.1016/j.drugalcdep.2017.02.017

 

Bottorff, J. L., Bissell, L. J., Balneaves, L. G., Oliffe, J. L., Capler, N. R., & Buxton, J. (2013). Perceptions of cannabis as a stigmatized medicine: A qualitative descriptive study. Harm Reduction Journal, 10(1), 2. https://doi.org/10.1186/1477-7517-10-2

 

Calapai, F., Cardia, L., Sorbara, E. E., Navarra, M., Gangemi, S., Calapai, G., & Mannucci, C. (2020). Cannabinoids, blood-brain barrier, and brain disposition. Pharmaceutics, 12(3), 265. https://doi.org/10.3390/pharmaceutics12030265

 

Canadian Centre on Substance Use and Addiction. (2019). 7 things about edible cannabishttps://www.ccsa.ca/sites/default/files/2019-06/CCSA-7-Things-About-Edible-Cannabis-2019-en.pdf 

 

Canadian Centre on Substance Use and Addiction. (2019). Edible cannabis: Always read the label. https://ccsa.ca/sites/default/files/2019-10/CCSA-Edible-Cannabis-Read-Label-Infographic-2019-en.pdf

 

Cannabis Regulations (SOR/2018-144). https://laws-lois.justice.gc.ca/eng/Regulations/SOR-2018-144/index.html  

 

Capano, A., Weaver, R., & Burkman, E. (2020). Evaluation of the effects of CBD hemp extract on opioid use and quality of life indicators in chronic pain patients: A prospective cohort study. Postgraduate Medicine, 132(1), 56-61. https://doi.org/10.1080/00325481.2019.1685298

 

Carter, G. T., Weydt, P., Kyashna-Tocha, M., & Abrams, D. I. (2004). Medicinal cannabis: Rational guidelines for dosing. IDrugs: The Investigational Drugs Journal, 7(5), 464-470. https://pubmed.ncbi.nlm.nih.gov/15154108/

 

Chait, L. D., & Zacny, J. P. (1992). Reinforcing and subjective effects of oral Δ 9-thc and smoked marijuana in humans. Psychopharmacology, 107(2), 255-262. https://doi.org/10.1007/BF02245145

 

Cone, E. J., Johnson, R. E., Paul, B. D., Mell, L. D., & Mitchell, J. (1988). Marijuana-laced brownies: Behavioral effects, physiologic effects, and urinalysis in humans following ingestion. Journal of Analytical Toxicology, 12(4), 169-175. https://doi.org/10.1093/jat/12.4.169

 

Craft, S., Winstock, A., Ferris, J., Mackie, C., Lynskey, M. T., & Freeman, T. P. (2020;2019;). Characterising heterogeneity in the use of different cannabis products: Latent class analysis with 55 000 people who use cannabis and associations with severity of cannabis dependence. Psychological Medicine, 50(14), 2364-2373. https://doi.org/10.1017/S0033291719002460 

 

Cranford, J. A., Bohnert, K. M., Perron, B. E., Bourque, C., & Ilgen, M. (2016). Prevalence and correlates of “Vaping” as a route of cannabis administration in medical cannabis patients. Drug and Alcohol Dependence, 169, 41– 47. http://doi.org/10.1016/j.drugalcdep.2016.10.008

 

CSSDP. (2018). Sensible cannabis education - A toolkit for educating youth. https://cssdp.org/uploads/2018/04/Sensible-Cannabis-Education-A-Toolkit-for-Educating-Youth.pdf

 

CSSDP. (2019). Cannabis harm reduction. https://cssdp.org/uploads/2019/09/Cannabis-Harm-Reduction.pdf 

 

Curran, V. H., Brignell, C., Fletcher, S., Middleton, P., & Henry, J. (2002). Cognitive and subjective dose-response effects of acute oral Δ 9-tetrahydrocannabinol (thc) in infrequent cannabis users. Psychopharmacology, 164(1), 61-70. https://doi.org/10.1007/s00213-002-1169-0

 

Cuttler, C., Mischley, L. K., & Sexton, M. (2016). Sex differences in cannabis use and effects: A cross-sectional survey of cannabis users. Cannabis and Cannabinoid Research, 1(1), 166-175. https://doi.org/10.1089/can.2016.0010

 

Dalgarno, P., & Shewan, D. (2005). Reducing the risks of drug use: The case for set and setting. Addiction Research & Theory, 13(3), 259-265. https://doi.org/10.1080/16066350500053562 

 

Ewusi Boisvert, E., Bae, D., Pang, R. D., Davis, J. P., Kelley-Quon, L. I., Barrington-Trimis, J. L., Kirkpatrick, M. G., Chai, S. H., & Leventhal, A. M. (2020). Subjective effects of combustible, vaporized, and edible cannabis: Results from a survey of adolescent cannabis users. Drug and Alcohol Dependence, 206, 107716. https://doi.org/10.1016/j.drugalcdep.2019.107716 

 

Farmer, S., Slavin, M. N., Loflin, M. J. E., Luba, R., & Earleywine, M. (2019). Aversiveness and meaningfulness of uncomfortable experiences with edible cannabis. Journal of Psychoactive Drugs, 51(5), 413-420. https://doi.org/10.1080/02791072.2019.1645371 

 

Fischer, B., Russell, C., Sabioni, P., Van Den Brink, W., Le Foll, B., Hall, W., Rehm, J., & Room, R. (2017). Lower-risk cannabis use guidelines: A comprehensive update of evidence and recommendations. American Journal of Public Health, 107(8), E1-E12. https://doi.org/10.2105/AJPH.2017.303818

 

Fligiel, S. E., Roth, M. D., Kleerup, E. C., Barsky, S. H., Simmons, M. S., & Tashkin, D. P. (1997). Tracheobronchial histopathology in habitual smokers of cocaine, marijuana, and/or tobacco. Chest, 112(2), 319-326. https://doi.org/10.1378/chest.112.2.319

 

Franciosi, A. (2017). THC patch: The ultimate guide to thc transdermal patches. Honest Marijuana. https://honestmarijuana.com/thc-patch/ 

 

Freeman, T. P., & Winstock, A. R. (2015). Examining the profile of high-potency cannabis and its association with severity of cannabis dependence. Psychological Medicine, 45(15), 3181-3189. https://doi.org/10.1017/S0033291715001178 

 

Geshtakovska, G., & Stefkov, G. (2016). Routes of cannabis administration: A brief review. Your hosts Macedonian Pharmaceutical Association and Faculty of Pharmacy, Ss Cyril and Methodius University in Skopje, 515. https://www.researchgate.net/profile/Marija-Vavlukis/publication/303899331_Impact_of_SLCO1B1_521TC_and_388AG_polymorphisms_on_response_to_atorvastatin_in_the_albanian_population/links/575bf9a708ae9a9c9556fa65/Impact-of-SLCO1B1-521TC-and-388AG-polymorphisms-on-response-to-atorvastatin-in-the-albanian-population.pdf#page=515

 

Ghosh, T. S., Van Dyke, M., Maffey, A., Whitley, E., Erpelding, D., & Wolk, L. (2015). Medical marijuana’s public health lessons—implications for retail marijuana in Colorado. The New England Journal of Medicine, 372(11), 991-993. https://doi.org/10.1056/NEJMp1500043 

 

Gieringer, D. H. (2001). Cannabis “Vaporization”: A promising strategy for smoke harm reduction. Journal of Cannabis Therapeutics, 1(3-4), 153-170. https://doi.org/10.1300/J175v01n03_10 

 

Giombi, K. C., Kosa, K. M., Rains, C., & Cates, S. C. (2018). Consumers' perceptions of edible marijuana products for recreational use: Likes, dislikes, and reasons for use. Substance use & Misuse, 53(4), 541-547. https://doi.org/10.1080/10826084.2017.1343353 

 

Government of Canada. (2019, December 13). Canadian Cannabis Survey 2019-Summary. https://www.canada.ca/en/health-canada/services/publications/drugs-health-products/canadian-cannabis-survey-2019-summary.html 

 

Government of Canada. (2019). Cannabis: Lower your risks. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/resources/loWer-your-risks.html

 

Government of Canada. (2019). Final regulations: Edible cannabis, cannabis extracts, cannabis topicalshttps://www.canada.ca/content/dam/hc-sc/documents/services/drugs-medication/cannabis/resources/final-regulations-edible-cannabis-extracts-topical-eng.pdf

 

Grewal, J. K., & Loh, L. C. (2020). Health considerations of the legalization of cannabis edibles. CMAJ : Canadian Medical Association Journal, 192(1), E1–E2. https://doi.org/10.1503/cmaj.191217 

 

Grof, C. P. L. (2018). Cannabis, from plant to pill. British Journal of Clinical Pharmacology, 84(11), 2463-2467. https://doi.org/10.1111/bcp.13618 

 

Grotenhermen, F. (2001). Harm reduction associated with inhalation and oral administration of cannabis and thc. Journal of Cannabis Therapeutics, 1(3-4), 133-152. https://doi.org/10.1300/J175v01n03_09

 

Grotenhermen, F. (2003). Clinical pharmacokinetics of cannabinoids. Journal of Cannabis Therapeutics, 3(1), 3-51. https://doi.org/10.1300/J175v03n01_02

 

Grotenhermen, F. (2007). The toxicology of cannabis and cannabis prohibition. Chemistry & Biodiversity, 4(8), 1744-1769. https://doi.org/10.1002/cbdv.200790151

 

Halperin, A. (2018). 'You're not going to die': How to survive an edible marijuana overdose. The Guardian. https://www.theguardian.com/society/2018/nov/18/marijuana-cannabis-edibles-overdose-too-much 

 

Hart, C. L., Ward, A. S., Haney, M., Comer, S. D., Foltin, R. W., & Fischman, M. W. (2002). Comparison of smoked marijuana and oral Δ9-tetrahydrocannabinol in humans. Psychopharmacology, 164(4), 407-415. https://doi.org/10.1007/s00213-002-1231-y

 

Hartogsohn, I. (2017). Constructing drug effects: A history of set and setting. Drug Science, Policy and Law.https://doi.org/10.1177/2050324516683325 

 

Haug, N. A., Padula, C. B., Sottile, J. E., Vandrey, R., Heinz, A. J., & Bonn-Miller, M. O. (2017). Cannabis use patterns and motives: A comparison of younger, middle-aged, and older medical cannabis dispensary patients. Addictive Behaviors, 72, 14-20. https://doi.org/10.1016/j.addbeh.2017.03.006 

 

Hazekamp, A., Ruhaak, R., Zuurman, L., van Gerven, J., & Verpoorte, R. (2006). Evaluation of a vaporizing device (Volcano) for the pulmonary administration of tetrahydrocannabinol. Journal of Pharmaceutical Sciences, 95(6), 1308 –1317. http://doi.org/10.1002/jps.20574 

 

Hillig, K. W., & Mahlberg, P. G. (2004). A chemotaxonomic analysis of cannabinoid variation in cannabis (Cannabaceae). American Journal of Botany, 91(6), 966-975. https://doi.org/10.3732/ajb.91.6.966

 

Huestis, M. A. (2007). Human cannabinoid pharmacokinetics. Chemistry & biodiversity, 4(8), 1770-1804. https://doi.org/10.1002/cbdv.200790152 

 

Jett, J., Stone, E., Warren, G., & Cummings, K. M. (2018). Cannabis use, lung cancer, and related issues. Journal of Thoracic Oncology, 13(4), 480-487. https://doi.org/10.1016/j.jtho.2017.12.013 

 

Jones, C. B., Hill, M. L., Pardini, D. A., & Meier, M. H. (2016). Prevalence and correlates of vaping cannabis in a sample of young adults. Psychology of Addictive Behaviors, 30(8), 915-921. https://doi.org/10.1037/adb0000217

 

Karschner, E. L., Darwin, W. D., Goodwin, R. S., Wright, S., & Huestis, M. A. (2011). Plasma cannabinoid pharmacokinetics following controlled oral Δ9-tetrahydrocannabinol and oromucosal cannabis extract administration. Clinical chemistry, 57(1), 66-75. https://doi.org/10.1373/clinchem.2010.152439

 

Kostadinov, V., & Roche, A. (2017). Bongs and baby boomers: Trends in cannabis use among older australians. Australasian Journal on Ageing, 36(1), 56-59. https://doi.org/10.1111/ajag.12357

 

Lamy, F. R., Daniulaityte, R., Sheth, A., Nahhas, R. W., Martins, S. S., Boyer, E. W., & Carlson, R. G. (2016). “Those edibles hit hard”: Exploration of twitter data on cannabis edibles in the U.S. Drug and Alcohol Dependence, 164, 64-70. https://doi.org/10.1016/j.drugalcdep.2016.04.029 

 

Lankenau, S. E., Fedorova, E. V., Reed, M., Schrager, S. M., Iverson, E., & Wong, C. F. (2017). Marijuana practices and patterns of use among young adult medical marijuana patients and non-patient marijuana users. Drug and Alcohol Dependence, 170, 181-188. https://doi.org/10.1016/j.drugalcdep.2016.10.025

 

Lau, N., Sales, P., Averill, S., Murphy, F., Sato, S., & Murphy, S. (2015). A safer alternative: Cannabis substitution as harm reduction. Drug and Alcohol Review, 34(6), 654-659. https://doi.org/10.1111/dar.12275 

 

Lau, N., Sales, P., Averill, S., Murphy, F., Sato, S., & Murphy, S. (2015). Responsible and controlled use: Older cannabis users and harm reduction. The International Journal on Drug Policy, 26(8), 709–718. https://doi.org/10.1016/j.drugpo.2015.03.008 

 

Lemberger, L., Martz, R., Rodda, B., Forney, R., & Rowe, H. (1973). Comparative pharmacology of Δ9-tetrahydrocannabinol and its metabolite, 11-OH-Δ9-tetrahydrocannabinol. The Journal of Clinical Investigation, 52(10), 2411-2417. https://doi.org/10.1172/JCI107431 

 

Levinsohn, E. A., & Hill, K. P. (2020). Clinical uses of cannabis and cannabinoids in the unitedstates. Journal of the Neurological Sciences, 411, 116717. https://doi.org/10.1016/j.jns.2020.116717

 

Loflin, M., & Earleywine, M. (2014). A new method of cannabis ingestion: The dangers of dabs? Addictive Behaviors, 39(10), 1430-1433. https://doi.org/10.1016/j.addbeh.2014.05.013 

 

Loflin, M., & Earleywine, M. (2015). No smoke, no fire: What the initial literature suggests regarding vapourized cannabis and respiratory risk. Canadian Journal of Respiratory Therapy: CJRT, 51(1), 7-9. https://pubmed.ncbi.nlm.nih.gov/26078621/

 

MacCallum, C. A., & Russo, E. B. (2018). Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine, 49, 12-19. https://doi.org/10.1016/j.ejim.2018.01.004

 

MacCoun, R. J., & Mello, M. M. (2015). Half-baked—the retail promotion of marijuana edibles. The New England Journal of Medicine, 372(11), 989-991. https://doi.org/10.1056/NEJMp1416014

 

Marangoni, I. P., & Marangoni, A. G. (2019). Cannabis edibles: Dosing, encapsulation, and stability considerations. Current Opinion in Food Science, 28, 1-6. https://doi.org/10.1016/j.cofs.2019.01.005 

 

Mariani, J. J., Brooks, D., Haney, M., & Levin, F. R. (2011). Quantification and comparison of marijuana smoking practices: Blunts, joints, and pipes. Drug and Alcohol Dependence, 113(2-3), 249-251. https://doi.org/10.1016/j.drugalcdep.2010.08.008

 

Marsot, A., Audebert, C., Attolini, L., Lacarelle, B., Micallef, J., & Blin, O. (2017). Population pharmacokinetics model of thc used by pulmonary route in occasional cannabis smokers. Journal of Pharmacological and Toxicological Methods, 85, 49-54. https://doi.org/10.1016/j.vascn.2017.02.003 

 

Moore, T. R. (2002). A primer of drug action: A concise nontechnical guide to the actions, uses, and side effects of psychoactive drugs, ninth edition. American Journal of Health-System Pharmacy, 59(11), 1130-1131. https://doi.org/10.1093/ajhp/59.11.1130a 

 

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. (2017). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12. https://doi.org/10.17226/24625

 

OCS. (n.d.). Intro to cannabis beverages. Retrieved October 20, 2021, from https://ocs.ca/blogs/cannabis-basics/intro-to-cannabis-beverages 

 

Ohlsson, A., Lindgren, J. E., Wahlen, A., Agurell, S., Hollister, L. E., & Gillespie, H. K. (1980). Plasma delta‐9‐tetrahydrocannabinol concentrations and clinical effects after oral and intravenous administration and smoking. Clinical Pharmacology & Therapeutics, 28(3), 409-416. https://doi.org/10.1038/clpt.1980.181

 

Pacula, R. L., Jacobson, M., & Maksabedian, E. J. (2016). In the weeds: a baseline view of cannabis use among legalizing states and their neighbours. Addiction (Abingdon, England), 111(6), 973-980. https://doi.org/10.1111/add.13282

 

Papaseit, E., Pérez-Mañá, C., Pérez-Acevedo, A. P., Hladun, O., Torres-Moreno, M. C., Muga, R., Torrens, M., & Farré, M. (2018). Cannabinoids: from pot to lab. International Journal of Medical Sciences, 15(12), 1286–1295. https://doi.org/10.7150/ijms.27087 

 

Perkins, D. (2021, August 5). Understanding milligram doses in cannabis drinks. Sorse Technology. https://sorsetech.com/understanding-milligram-doses-in-cannabis-drinks/ 

 

Ribeiro, L. I., & Ind, P. W. (2016). Effect of cannabis smoking on lung function and respiratory symptoms: A structured literature review. NPJ Primary Care Respiratory Medicine, 26(1), 16071. https://doi.org/10.1038/npjpcrm.2016.71

 

Rotermann, M. (2021). Looking back from 2020, how cannabis use and related behaviours changed in canada. Health Reports, 32(4), 3-14. https://doi.org/10.25318/82-003-x202100400001-eng

 

Russell, C., Rueda, S., Room, R., Tyndall, M., & Fischer, B. (2018). Routes of administration for cannabis use – basic prevalence and related health outcomes: A scoping review and synthesis. The International Journal of Drug Policy, 52, 87-96. https://doi.org/10.1016/j.drugpo.2017.11.008

 

Russo E. B. (2011). Taming thc: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology, 163(7), 1344–1364. https://doi.org/10.1111/j.1476-5381.2011.01238.x 

 

Sadhir, M. (2016). Pharmacology of cannabis. Journal of Pain Management, 9(4), 375-379. https://uknowledge.uky.edu/pediatrics_facpub/265/

 

Schauer, G. L., King, B. A., Bunnell, R. E., Promoff, G., & McAfee, T. A. (2016). Toking, vaping, and eating for health or fun: Marijuana use patterns in adults, U.S., 2014. American Journal of Preventive Medicine, 50(1), 1-8. https://doi.org/10.1016/j.amepre.2015.05.027

 

Schlienz, N. J., Spindle, T. R., Cone, E. J., Herrmann, E. S., Bigelow, G. E., Mitchell, J. M., Flegel, R., LoDico, C., & Vandrey, R. (2020). Pharmacodynamic dose effects of oral cannabis ingestion in healthy adults who infrequently use cannabis. Drug and Alcohol Dependence, 211, 107969. https://doi.org/10.1016/j.drugalcdep.2020.107969

 

Schmidt, E. (2020, February 6). Water-soluble cannabinoids: A challenge and solution for the cannabis beverage market. ACS Laboratory. https://acslabcannabis.com/blog/cannabinoids/water-soluble-cannabinoids-a-challenge-and-solution-for-the-cannabis-beverage-market/ 

 

Shakya, P., Madhav, N. V. S., Shakya, A. K., & Singh, K. (2011). Palatal mucosa as a route for systemic drug delivery: A review. Journal of Controlled Release, 151(1), 2-9. https://doi.org/10.1016/j.jconrel.2010.11.003 

 

Shiplo, S., Asbridge, M., Leatherdale, S. T., & Hammond, D. (2016). Medical cannabis use in Canada: Vapourization and modes of delivery. Harm Reduction Journal, 13(1), 30. https://doi.org/10.1186/s12954-016-0119-9

 

Simpson, K. A., Cho, J., & Barrington-Trimis, J. L. (2021). The association of type of cannabis product used and frequency of use with problematic cannabis use in a sample of young adult cannabis user. Drug and Alcohol Dependence, 226, 108865-108865. https://doi.org/10.1016/j.drugalcdep.2021.108865 

 

Sith, D., Bloor, R., George, C., Pysanenko, A., & Španěl, P. (2015). Release of toxic ammonia and volatile organic compounds by heated cannabis and their relation to tetrahydrocannabinol content. Analytical Methods, 7(10), 4104-4110. https://doi.org/10.1039/C5AY00593K 

 

Subritzky, T., Pettigrew, S., & Lenton, S. (2016). Issues in the implementation and evolution of the commercial recreational cannabis market in Colorado. International Journal of Drug Policy, 27, 1-12. https://doi.org/10.1016/j.drugpo.2015.12.001

 

Swan, C., Ferro, M. A., & Thompson, K. (2021). Does how you use matter? The link between mode of use and cannabis-related risk. Addictive Behaviors, 112, 106620-106620. https://doi.org/10.1016/j.addbeh.2020.106620 

 

Tetrault, J. M., Crothers, K., Moore, B. A., Mehra, R., Concato, J., & Fiellin, D. A. (2007). Effects of marijuana smoking on pulmonary function and respiratory complications: A systematic review. Archives of Internal Medicine, 167(3), 221–228. https://doi.org/10.1001/archinte.167.3.221

 

The Canadian Press. (2019, October 18). Edibles, vapes and oils: What you need to know about cannabis 2.0. CTV News. https://www.ctvnews.ca/canada/edibles-vapes-and-oils-what-you-need-to-know-about-cannabis-2-0-1.4644511 

 

Timberlake, D. S. (2009). A comparison of drug use and dependence between blunt smokers and other cannabis users. Substance use & Misuse, 44(3), 401-415. https://doi.org/10.1080/10826080802347651 

 

United Nations Office on Drugs and Crime. (2009). World drug report. https://www.unodc.org/documents/wdr/WDR_2009/WDR2009_eng_web.pdf

 

Urits, I., Gress, K., Charipova, K., Habib, K., Lee,  D., Lee, C., Jung, J. W., Kassem, H., Cornett, E., Paladini, A., Varrassi, G., Kaye, A., D., Viswanath, O. (2020). Use of cannabidiol (CBD) for the treatment of chronic pain. Best Practice & Research. Clinical Anaesthesiology, 34(3), 463-477. https://doi.org/10.1016/j.bpa.2020.06.004

 

van der Pol, P., Liebregts, N., Brunt, T., van Amsterdam, J., de Graaf, R., Korf, D. J., van den Brink, W., & van Laar, M. (2014). Cross-sectional and prospective relation of cannabis potency, dosing and smoking behaviour with cannabis dependence: An ecological study. Addiction (Abingdon, England), 109(7), 1101-1109. https://doi.org/10.1111/add.12508 

 

Varlet, V., Concha-Lozano, N., Berthet, A., Plateel, G., Favrat, B., De Cesare, M., Lauer, E., Augsburger, M., Thomas, A. and Giroud, C. (2016). Drug vaping applied to cannabis: Is “Cannavaping” a therapeutic alternative to marijuana? Scientific reports, 6(1), 25599. https://doi.org/10.1038/srep25599

 

Wang, M., Wang, Y., Avula, B., Radwan, M. M., Wanas, A. S., van Antwerp, J., Parcher, J. F., ElSohly, M. A., & Khan, I. A. (2016). Decarboxylation study of acidic cannabinoids: A novel approach using ultra-high-performance supercritical fluid chromatography/photodiode array-mass spectrometry. Cannabis and Cannabinoid Research, 1(1), 262-271. https://doi.org/10.1089/can.2016.0020 

 

Watanabe, K., Yamaori, S., Funahashi, T., Kimura, T., & Yamamoto, I. (2007). Cytochrome p450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes. Life Sciences, 80(15), 1415-1419. https://doi.org/10.1016/j.lfs.2006.12.032 

 

Watkins, A. (2020, March 4). Understanding edible and beverage onset times. Cannabis Retailer. https://cannabisretailer.ca/2020/understanding-edible-and-beverage-onset-times/ 

 

White, A. E., Van Tubbergen, C., Raymes, B., Contreras, A. E., & Scallan Walter, E. J. (2020). Cannabis-infused edible products in colorado: Food safety and public health implications. American Journal of Public Health, 110(6), 790-795. https://doi.org/10.2105/AJPH.2020.305601

 

Zinberg, N. E. (1984). Drug, set, and setting: The basis for controlled intoxicant use. Yale University Press. 

 

Abizaid, A., Merali, Z., & Anisman, H. (2019). Cannabis: A potential efficacious intervention for ptsd or simply snake oil? Journal of Psychiatry & Neuroscience: JPN, 44(2), 75-78. https://doi.org/10.1503/jpn.190021

 

Abrams, D. I. (2018). The therapeutic effects of cannabis and cannabinoids: An update from the national academies of sciences, engineering and medicine report. European Journal of Internal Medicine, 49, 7-11. https://doi.org/10.1016/j.ejim.2018.01.003

 

Addison, S. (2017). How can cannabis help in the treatment of depression. Cannabis Digest. https://cannabisdigest.ca/cannabis-treatment-depression/

 

A guide to microdosing cannabis. (n.d.). Green Sativa. https://greensativa.com/guide-to-microdosing-cannabis/

 

Alkadhi, K., Zagaar, M., Alhaider, I., Salim, S., & Aleisa, A. (2013). Neurobiological consequences of sleep deprivation. Current Neuropharmacology, 11(3), 231-249. https://doi.org/10.2174/1570159X11311030001

 

Anderson, D. M., Rees, D. I., & Sabia, J. J. (2012). High on life? Medical marijuana laws and suicide. American Journal of Public Health (1971), 104(12), 2369-2376. https://doi.org/10.2105/AJPH.2013.301612

 

Anxiety. (2021). American Psychological Association. https://www.apa.org/topics/anxiety/

 

Arendt, M., Rosenberg, R., Foldager, L., Perto, G., & Munk-Jørgensen, P. (2005). Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: Follow-up study of 535 incident cases. British Journal of Psychiatry, 187(6), 510-515. https://doi.org/10.1192/bjp.187.6.510

 

Arkowitz, H., & Lilienfeld, S. (2021, March 1). Experts tell the truth about pot. Scientific American. https://www.scientificamerican.com/article/the-truth-about-pot/

 

Aronin, T. (2018). In michigan will cannabis-infused drinks elbow beer off the shelves? 517 Mag. https://517mag.com/business/in-michigan-will-cannabis-infused-drinks-elbow-beer-off-the-shelves/

 

Bally, N., Zullino, D., & Aubry, J. (2014). Cannabis use and first manic episode. Journal of Affective Disorders, 165, 103-108. https://doi.org/10.1016/j.jad.2014.04.038

 

Bhattacharyya, S., Egerton, A., Kim, E., Rosso, L., Riano Barros, D., Hammers, A., Brammer, M., Turkheimer, F. E., Howes, O. D., & McGuire, P. (2017). Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (cb1) receptors. Scientific Reports, 7(1), 15025-15. https://doi.org/10.1038/s41598-017-14203-4

 

Bipolar disorder. (n.d.). Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/bipolar-disorder/symptoms-causes/syc-20355955

 

Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 12(4), 825-836. https://doi.org/10.1007/s13311-015-0387-1

 

Boden, M. T., Babson, K. A., Vujanovic, A. A., Short, N. A., & Bonn‐Miller, M. O. (2013). Posttraumatic stress disorder and cannabis use characteristics among military veterans with cannabis dependence. The American Journal on Addictions, 22(3), 277-284. https://doi.org/10.1111/j.1521-0391.2012.12018.x

 

Bolla, K. I., Lesage, S. R., Gamaldo, C. E., Neubauer, D. N., Funderburk, F. R., Lud Cadet, J., David, P. M., Verdejo-Garcia, A., & Benbrook, A. R. (2008). Sleep disturbance in heavy marijuana users. Sleep, 31(6), 901-908. https://doi.org/10.1093/sleep/31.6.901

 

Bonn-Miller, M. O., Babson, K. A., & Vandrey, R. (2013;2014;). Using cannabis to help you sleep: Heightened frequency of medical cannabis use among those with ptsd. Drug and Alcohol Dependence, 136, 162-165. https://doi.org/10.1016/j.drugalcdep.2013.12.008

 

Bonn‐Miller, M. O., Vujanovic, A. A., Feldner, M. T., Bernstein, A., & Zvolensky, M. J. (2007). Posttraumatic stress symptom severity predicts marijuana use coping motives among traumatic event‐exposed marijuana users. Journal of Traumatic Stress, 20(4), 577-586. https://doi.org/10.1002/jts.20243

 

Bonn-Miller, M. O., & Zvolensky, M. J. (2009). An evaluation of the nature of marijuana use and its motives among young adult active users. American Journal on Addictions, 18(5), 409-416. https://pubmed.ncbi.nlm.nih.gov/19874161/

 

Boys, A., Marsden, J., Griffiths, P., Fountain, J., Stillwell, G., & Strang, J. (1999). Substance use among young people: The relationship between perceived functions and intentions. Addiction (Abingdon, England), 94(7), 1043-1050. https://doi.org/10.1046/j.1360-0443.1999.94710439.x

 

Braida, D., Limonta, V., Malabarba, L., Zani, A., & Sala, M. (2007). 5-ht1a receptors are involved in the anxiolytic effect of Δ9-tetrahydrocannabinol and am 404, the anandamide transport inhibitor, in sprague–dawley rats. European Journal of Pharmacology, 555(2-3), 156-163. https://doi.org/10.1016/j.ejphar.2006.10.038

 

Braga, R. J., Burdick, K. E., DeRosse, P., Malhotra, A. K. (2012). Cognitive and clinical outcomes associated with cannabis use in patients with bipolar I disorder. Psychiatry Research, 200(2-3), 242-245. https://doi.org/10.1016/j.psychres.2012.05.025

 

Brown, A. S. (2011). The environment and susceptibility to schizophrenia. Progress in Neurobiology, 93(1), 23-58. https://doi.org/10.1016/j.pneurobio.2010.09.003

 

Buckner, J. D., Crosby, R. D., Wonderlich, S. A., & Schmidt, N. B. (2011;2012;). Social anxiety and cannabis use: An analysis from ecological momentary assessment. Journal of Anxiety Disorders, 26(2), 297-304. https://doi.org/10.1016/j.janxdis.2011.12.006 

 

CAMH. (n.d.). Psychosishttps://www.camh.ca/en/health-info/mental-illness-and-addiction-index/psychosis

 

Campos A, Guimarães F. S. (2008). Involvement of 5ht1a receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats. Psychopharmacology 199(2): 223–230. https://doi.org/10.1007/s00213-008-1168-x

 

Carney, R., Cotter, J., Firth, J., Bradshaw, T., & Yung, A. R. (2017). Cannabis use and symptom severity in individuals at ultra high risk for psychosis: A meta‐analysis. Acta Psychiatrica Scandinavica, 136(1), 5-15. https://doi.org/10.1111/acps.12699

 

Casadio, P., Fernandes, C., Murray, R. M., & Di Forti, M. (2011). Cannabis use in young people: The risk for schizophrenia. Neuroscience and Biobehavioral Reviews, 35(8), 1779-1787. https://doi.org/10.1016/j.neubiorev.2011.04.007 

 

Chandra, S., Radwan, M. M., Majumdar, C. G., Church, J. C., Freeman, T. P., & ElSohly, M. A. (2019). New trends in cannabis potency in usa and europe during the last decade (2008–2017). European Archives of Psychiatry and Clinical Neuroscience, 269(1), 5-15. https://doi.org/10.1007/s00406-019-00983-5

 

Chan, G. C., Hall, W., Freeman, T. P., Ferris, J., Kelly, A. B., & Winstock, A. (2017). User characteristics and effect profile of butane hash oil: An extremely high-potency cannabis concentrate. Drug and Alcohol Dependence, 178, 32-38. https://doi.org/10.1016/j.drugalcdep.2017.04.014

 

Chen, M. (2009). Does cannabis cause or treat anxiety? Medical News Today.  https://www.medicalnewstoday.com/articles/marijuana-and-anxiety

 

Choi, N. G., DiNitto, D. M., & Phillips, K. T. (2021). Mental health treatment use among cannabis users aged 50+: Associations with cannabis use characteristics. Drug and Alcohol Dependence, 223, 108705. https://doi.org/10.1016/j.drugalcdep.2021.108705

 

Clausen, L., Hjorthoj, C. R., Thorup, A., Jeppesen, P., Petersen, L., Bertelsen, M., & Nordentoft, M. (2014). Change in cannabis use, clinical symptoms and social functioning among patients with first-episode psychosis: A 5-year follow-up study of patients in the opus trial. Psychological Medicine, 44(1), 117-126. https://doi.org/10.1017/S0033291713000433

 

Clough, A. R., D’Abbs P., Cairney, S., Gray, D., Maruff, P., Parker, R., & O’reilly, B. (2005). Adverse mental health effects of cannabis use in two indigenous communities in arnhem land, northern territory, australia: Exploratory study. Australian and New Zealand Journal of Psychiatry, 39(7), 612–620. https://doi.org/10.1080/j.1440-1614.2005.01634.x

 

Compton III, W. M., Cottler, L. B., Ben Abdallah, A., Phelps, D. L., Spitznagel, E. L., & Horton, J. C. (2000). Substance dependence and other psychiatric disorders among drug dependent subjects: Race and gender correlates. The American Journal on Addictions, 9(2), 113-125. https://doi.org/10.1080/10550490050173181

 

Conger, J. J. (1956). II. Reinforcement theory and the dynamics of alcoholism. Quarterly Journal of Studies on Alcohol, 17(2), 296-305. https://doi.org/10.15288/qjsa.1956.17.296

 

Cousens, K., & DiMascio, A. (1973). (−)δ9THC as an hypnotic. Psychopharmacologia, 33, 355–364 (1973). https://doi.org/10.1007/BF00437513

 

Crippa, J. A., Derenusson, G. N., Ferrari, T. B., Wichert-Ana, L., Duran, F. L., Martin-Santos, R., Simoes, M. V., Bhattacharyya, S., Fusar-Poli, P., Atakan, Z., Santos Filho, A., Freitas-Ferrari, M. C., McGuire, P. K., Zuardi, A. W., Busatto, G. F., & Hallak, J. E. C. (2011). Neural basis of anxiolytic effects of cannabidiol (cbd) in generalized social anxiety disorder: a preliminary report. Journal of Psychopharmacology (Oxford, England), 25(1), 121-130. https://doi.org/10.1177/0269881110379283

 

Crippa, J. A., Zuardi, A. W., Garrido, G. E., Wichert-Ana, L., Guarnieri, R., Ferrari, L., Azevedo-Marques, P. M., Hallak, J. E., McGuire, P. K., & Filho Busatto, G. (2004). Effects of cannabidiol (cbd) on regional cerebral blood flow. Neuropsychopharmacology, 29(2), 417–426. https://doi.org/10.1038/sj.npp.1300340

 

Crippa, J. A., Zuardi, A. W., Martín-Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., & Fusar-Poli, P. (2009). Cannabis and anxiety: A critical review of the evidence. Human Psychopharmacology, 24(7), 515-523. https://doi.org/10.1002/hup.1048

 

Crocker, C. E., Carter, A. J. E., Emsley, J. G., Magee, K., Atkinson, P., & Tibbo, P. G. (2021). When cannabis use goes wrong: Mental health side effects of cannabis use that present to emergency services. Frontiers in Psychiatry, 12, 640222. https://doi.org/10.3389/fpsyt.2021.640222

 

Cuttler, C., Spradlin, A., & McLaughlin, R. J. (2018). A naturalistic examination of the perceived effects of cannabis on negative affect. Journal of Affective Disorders, 235, 198-205. https://doi.org/10.1016/j.jad.2018.04.054

 

Dannon, P. N., Lowengrub, K., Amiaz, R., Grunhaus, L., & Kotler, M. (2004). Comorbid cannabis use and panic disorder: Short term and long term follow‐up study. Human Psychopharmacology: Clinical and Experimental, 19(2), 97-101. https://doi.org/10.1002/hup.560

 

Deas, D., Gerding, L., & Hazy, J. (2000). Marijuana and panic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 39(12), 1467. https://doi.org/10.1097/00004583-200012000-00006

 

Degenhardt, L., Hall, W., & Lynskey, M. (2003). Exploring the association between cannabis use and depression. Addiction (Abingdon, England), 98(11), 1493-1504. https://doi.org/10.1046/j.1360-0443.2003.00437.x

 

DeVylder, J. E., & Lukens, E. P. (2013). Family history of schizophrenia as a risk factor for axis I psychiatric conditions. Journal of Psychiatric Research, 47(2), 181–187. https://doi.org/10.1016/j.jpsychires.2012.09.023

 

Dorard, G., Berthoz, S., Phan, O., Corcos, M., & Bungener, C. (2008). Affect dysregulation in cannabis abusers: A study in adolescents and young adults. European Child & Adolescent Psychiatry, 17(5), 274–282. https://doi.org/10.1007/s00787-007-0663-7

 

Dreher, M. (2002). Crack heads and roots daughters: The therapeutic use of cannabis in jamaica. Journal of Cannabis Therapeutics, 2(3-4), 121-133. https://doi.org/10.1300/J175v02n03_08

 

D'Souza, D. C., Perry, E., MacDougall, L., Ammerman, Y., Cooper, T., Braley, G., Gueorguieva, R., & Krystal, J. H. (2004). The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: Implications for psychosis. Neuropsychopharmacology, 29(8), 1558-1572. https://doi.org/10.1038/sj.npp.1300496

 

Earlenbaugh, E. (2020). New research reveals why cannabis helps ptsd sufferers. Forbes. https://www.forbes.com/sites/emilyearlenbaugh/2020/09/17/new-research-reveals-why-cannabis-helps-ptsd-sufferers/?sh=26183289179a

 

Farris, M. S., Shakeel, M. K., & Addington, J. (2020). Cannabis use in individuals at clinical high-risk for psychosis: A comprehensive review. Social Psychiatry and Psychiatric Epidemiology, 55(5), 527-537. https://doi.org/10.1007/s00127-019-01810-x

 

Feingold, D., & Weinstein, A. (2021). Cannabis and Depression. Advances in Experimental Medicine and Biology, 1264, 67-80. https://doi.org/10.1007/978-3-030-57369-0_5

 

Fischer, B., Jeffries, V., Hall, W., Room, R., Goldner, E., & Rehm, J. (2011). Lower risk cannabis use guidelines for canada (lrcug): A narrative review of evidence and recommendations. Canadian Journal of Public Health, 102(5), 324-327. https://doi.org/10.1007/BF03404169

 

Fischer, B., Russell, C., Sabioni, P., van den Brink, W., Le Foll, B., Hall, W., Rehm, J., & Room, R. (2017). Lower-risk cannabis use guidelines: A comprehensive update of evidence and recommendations. American Journal of Public Health (1971), 107(8), E1-E12. https://doi.org/10.2105/AJPH.2017.303818 

 

Freeman, T. P., & Winstock, A. R. (2015). Examining the profile of high-potency cannabis and its association with severity of cannabis dependence. Psychological Medicine, 45(15), 3181-3189. https://doi.org/10.1017/S0033291715001178

 

Garrison, E., Gilligan, C., Ladd, B. O., & Anderson, K. G. (2021). Social anxiety, cannabis use motives, and social context’s impact on willingness to use cannabis. International Journal of Environmental Research and Public Health, 18(9), 4882. https://doi.org/10.3390/ijerph18094882

 

Gibbs, M., Winsper, C., Marwaha, S., Gilbert, E., Broome, M., & Singh, S. P. (2015). Cannabis use and mania symptoms: A systematic review and meta-analysis. Journal of Affective Disorders, 171, 39-47. https://doi.org/10.1016/j.jad.2014.09.016

 

Gillette, H. (2021). Does cannabis use affect bipolar disorder symptoms. Psychcentral. https://psychcentral.com/bipolar/cannabis-bipolar-disorder-symptoms

 

Giordano, G.N., Ohlsson, H., Sundquist, K., Sundquist, J., & Kendler, K. (2015). The association between cannabis abuse and subsequent schizophrenia: A swedish national co-relative control study. Psychological Medicine, 45(2), 407–414. https://doi.org/10.1017/S0033291714001524

 

Gregg, J. M., Small, E. W., Moore, R., Raft, D., & Toomey, T. C. (1976). Emotional response to intravenous delta9tetrahydrocannabinol during oral surgery. Journal of Oral Surgery (American Dental Association: 1965), 34(4), 301-313. https://pubmed.ncbi.nlm.nih.gov/1062533/

 

Grewal, J. K., & Loh, L. C. (2020). Health considerations of the legalization of cannabis edibles. Canadian Medical Association Journal (CMAJ), 192(1), E1-E2. https://doi.org/10.1503/cmaj.191217 

 

Grewal. S., & George. T. (2017). Cannabis-induced psychosis: A review. Psychiatric Times, 34(7). https://www.psychiatrictimes.com/view/cannabis-induced-psychosis-review

 

Grunberg, V. A., Cordova, K. A., Bidwell, L. C., & Ito, T. A. (2015). Can marijuana make it better? Prospective effects of marijuana and temperament on risk for anxiety and depression. Psychology of Addictive Behaviors, 29(3), 590-602. https://doi.org/10.1037/adb0000109

 

Guimarães, F. S., Chiaretti, T. M., Graeff, F. G., and Zuardi, A. W. (1990). Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology, 100(4), 558–559. https://doi.org/10.1007/BF02244012

 

Guzman, F. ( 2019). 5-ht1a receptors in psychopharmacology. Psychopharmacology Institutehttps://psychopharmacologyinstitute.com/publication/5-ht1a-receptors-in-psychopharmacology-2123

 

Hall, W. (2015). What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? Addiction (Abingdon, Endlang), 110(1), 19-35. https://doi.org/10.1111/add.12703

 

Hall, W., Hoch, E., & Lorenzetti, V. (2019). Cannabis use and mental health: Risks and benefits. European Archives of Psychiatry and Clinical Neuroscience, 269(1), 1-3. https://doi.org/10.1007/s00406-019-00986-2

 

Hall, W., & Solowij, N. (1998). Adverse effects of cannabis. Lancet (London, England), 352(9140), 1611-1616. https://doi.org/10.1016/S0140-6736(98)05021-1

 

Hartogsohn, I. (2017). Constructing drug effects: A history of set and setting. Drug Science, Policy and Law. https://doi.org/10.1177/2050324516683325

 

Hasin, D. S., Saha, T. D., Kerridge, B. T., Goldstein, R. B., Chou, S. P., Zhang, H., Jung, J., Pickering, R. P., Ruan, W. J., Smith, S. M., Huang, B., & Grant, B. F. (2015). Prevalence of marijuana use disorders in the united states between 2001-2002 and 2012-2013. JAMA Psychiatry, 72(12), 1235-1242. https://doi.org/10.1001/jamapsychiatry.2015.1858

 

Hathaway, A. D. (2003). Cannabis effects and dependency concerns in long-term frequent users: A missing piece of the public health puzzle. Addiction Research & Theory, 11(6), 441-458. https://doi.org/10.1080/1606635021000041807

 

Henquet, C., Di Forti, M., Morrison, P., Kuepper, R., & Murray, R. M. (2008). Gene-environment interplay between cannabis and psychosis. Schizophrenia Bulletin, 34(6), 1111-1121. https://doi.org/10.1093/schbul/sbn108

 

Henquet, C., Krabbendam, L., de Graaf, R., ten Have, M., & van Os, J. (2006). Cannabis use and expression of mania in the general population. Journal of Affective Disorders, 95(1–3), 103–110. https://doi.org/10.1016/j.jad.2006.05.002

 

Hodgson, K., Coleman, J. R. I., Hagenaars, S. P., Purves, K. L., Glanville, K., Choi, S. W., O'Reilly, P., Breen, G., Lewis, C. M., & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. (2020). Cannabis use, depression and self‐harm: Phenotypic and genetic relationships. Addiction (Abingdon, England), 115(3), 482-492. https://doi.org/10.1111/add.14845 

 

Hollister, L. E. (1986). Health aspects of cannabis. Pharmacological Reviews, 38(1), 1-20. https://pubmed.ncbi.nlm.nih.gov/3520605/

 

Huizink, A. C. (2013). Commentary on degenhardt et al. (2013): Specific effect of adolescent cannabis use on anxiety – Tentative explanations. Addiction (Abingdon, England), 108(1), 134-135. https://doi.org/10.1111/add.12046

 

Iliades, C. (2012). Depression’s effect on your appetite. Everyday Health. https://www.everydayhealth.com/hs/major-depression/depressions-effect-on-appetite/

 

Innamorati, M., Pompili, M., Ferrari, V., Girardi, P., Tatarelli, R., Tamburello, A., & Lester, D. (2008). Cannabis use and the risk behavior syndrome in italian university students: Are they related to suicide risk? Psychological Reports, 102(2), 577-594. https://doi.org/10.2466/pr0.102.2.577-594

 

Kamal, B. S., Kamal, F., & Lantela, D. E. (2018). Cannabis and the anxiety of fragmentation-A systems approach for finding an anxiolytic cannabis chemotype. Frontiers in Neuroscience, 12, 730. https://doi.org/10.3389/fnins.2018.00730

 

Kaplan, H. B., Martin, S. S., Johnson, R. J., & Robbins, C. A. (1986). Escalation of marijuana use: Application of a general theory of deviant behavior. Journal of Health and Social Behavior, 27(1), 44-61. https://doi.org/10.2307/2136502

 

Kedzior, K. K., & Laeber, L. T. (2014). A positive association between anxiety disorders and cannabis use or cannabis use disorders in the general population--a meta-analysis of 31 studies. BMC Psychiatry, 14(1), 136-136. https://doi.org/10.1186/1471-244X-14-136 

 

Kim, S. W., Dodd, S., Berk, L., Kulkarni, J., de Castella, A., Fitzgerald, P. B., Kim, J. M., Yoon, J. S., & Berk, M. (2015). Impact of cannabis use on long-term remission in bipolar I and schizoaffective disorder. Psychiatry Investigation, 12(3), 349-355. https://doi.org/10.4306/pi.2015.12.3.349

 

Konefal, S., Gabrys, R., & Porath, A. (2019). Clearing the smoke on cannabis. Canadian Centre on Substance Use and Addiction. https://www.ccsa.ca/clearing-smoke-cannabis-regular-use-and-mental-health

 

Korem, N., Zer-Aviv, T. M., Ganon-Elazar, E., Abush, H., & Akirav, I. (2016). Targeting the endocannabinoid system to treat anxiety-related disorders. Journal of Basic and Clinical Physiology and Pharmacology, 27(3), 193-202. https://doi.org/10.1515/jbcpp-2015-0058

 

Kraan, T., Velthorst, E., Koenders, L., Zwaart, K., Ising, H. K., van den Berg, D., de Haan, L., & van der Gaag, M. (2016). Cannabis use and transition to psychosis in individuals at ultra-high risk: Review and meta-analysis. Psychological Medicine, 46(4), 673-681. https://doi.org/10.1017/S0033291715002329

 

Ksir, C., & Hart, C. L. (2016). Cannabis and psychosis: A critical overview of the relationship. Current Psychiatry Reports, 18(2), 1-11. https://doi.org/10.1007/s11920-015-0657-y

 

Lake, S., Kerr, T., Buxton, J., Walsh, Z., Marshall, B. D., Wood, E., & Milloy, M. (2020). Does cannabis use modify the effect of post-traumatic stress disorder on severe depression and suicidal ideation? Evidence from a population-based cross-sectional study of canadians. Journal of Psychopharmacology (Oxford, England), 34(2), 181-188. https://doi.org/10.1177/0269881119882806

 

Lake, S., Kerr, T., Werb, D., Haines‐Saah, R., Fischer, B., Thomas, G., Walsh, Z., Ware, M. A., Wood, E., & Milloy, M. (2019). Guidelines for public health and safety metrics to evaluate the potential harms and benefits of cannabis regulation in canada. Drug and Alcohol Review, 38(6), 606-621. https://doi.org/10.1111/dar.12971  

 

Langs, G., Fabisch, H., Fabisch, K., & Zapotoczky, H. G. (1997). Can cannabis trigger recurrent panic attacks in susceptible patients? European Psychiatry, 12(8), 415-419. https://doi.org/10.1016/S0924-9338(97)83568-7

 

Lau, N., Sales, P., Averill, S., Murphy, F., Sato, S., & Murphy, S. (2015). A safer alternative: Cannabis substitution as harm reduction. Drug and Alcohol Review, 34(6), 654-659. https://doi.org/10.1111/dar.12275 

 

Lesch, K. P., Wiesmann, M., Hoh, A., Muller, T., Disselkamp-Tietze, J., Osterheider, M., & Schulte, H. M. (1992). 5-ht1a receptor-effector system responsivity in panic disorder. Psychopharmacology, 106(1), 111-7. https://doi.org/10.1007/BF02253597

 

Lev-Ran, S., Le Foll, B., McKenzie, K., George, T. P., & Rehm, J. (2013). Cannabis use and cannabis use disorders among individuals with mental illness. Comprehensive Psychiatry, 54(6), 589-598. https://doi.org/10.1016/j.comppsych.2012.12.021

 

Leweke, F. M., Piomelli, D., Pahlisch, F., Muhl, D., Gerth, C. W., Hoyer, C., Klosterkötter, J., Hellmich, M., & Koethe, D. (2012). Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia. Translational Psychiatry, 2(3), e94-e94. https://doi.org/10.1038/tp.2012.15

 

Linscott, R. J., & van Os, J. (2013). An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: On the pathway from proneness to persistence to dimensional expression across mental disorders. Psychological Medicine, 43(6), 1133-1149. https://doi.org/10.1017/S0033291712001626

 

Lowe, D. J. E., Sasiadek, J. D., Coles, A. S., & George, T. P. (2019). Cannabis and mental illness: A review. European Archives of Psychiatry and Clinical Neuroscience, 269(1), 107-120. https://doi.org/10.1007/s00406-018-0970-7

 

Lucas, P. (2012). Cannabis as an adjunct to or substitute for opiates in the treatment of chronic pain. Journal of Psychoactive Drugs, 44(2), 125–33. https://doi.org/10.1080/02791072.2012.684624

 

Lucas, P., Reiman, A., Earleywine, M., McGowan, S. K., Oleson, M., Coward, M. P., & Thomas, B. (2013). Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in canadian medical cannabis patients. Addiction Research & Theory, 21(5), 435–442. https://doi.org/10.3109/16066359.2012.733465

 

Lynskey, M. T., Heath, A. C., Nelson, E. C., Bucholz, K. K., Madden, P. A. F., Slutske, W. S., Statham, D. J., & Martin, N. G. (2002). Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. Psychological Medicine, 32(2), 195-207. https://doi.org/10.1017/s0033291701005062

 

Manzanares, J., Urigüen, L., Rubio, G., & Palomo, T. (2004). Role of endocannabinoid system in mental diseases. Neurotoxicity Research, 6(3), 213-224. https://doi.org/10.1007/BF03033223

 

Marconi, A., Di Forti, M., Lewis, C. M., Murray, R. M., & Vassos, E. (2016). Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophrenia Bulletin, 42(5), 1262-1269. https://doi.org/10.1093/schbul/sbw003

 

McGee, R., Williams, S., Poulton, R., & Moffitt, T. (2000). A longitudinal study of cannabis use and mental health from adolescence to early adulthood. Addiction (Abingdon, England), 95(4), 491-503. https://doi.org/10.1046/j.1360-0443.2000.9544912.x

 

McGill University. (2007). Cannabis: Potent anti-depressant in low doses, worsens depression at high doses. https://www.sciencedaily.com/releases/2007/10/071023183937.htm

 

McGuire, P., Robson, P., Cubala, W. J., Vasile, D., Morrison, P. D., Barron, R., Taylor, A., & Wright, S. (2018). Cannabidiol (CBD) as an adjunctive therapy in schizophrenia: A multicenter randomized controlled trial. The American Journal of Psychiatry, 175(3), 225-231. https://doi.org/10.1176/appi.ajp.2017.17030325

 

Medical cannabis for anxiety. (n.d.). Cannabis clinics. https://www.cannabisclinics.ca/medical-cannabis/anxiety/

 

Mental Health Commission of Canada. (2019). Cannabis and mental health: Priorities for research in canada. https://www.mentalhealthcommission.ca/wp-content/uploads/drupal/2019-07/Cannabis_mental_Health_Summary_july_2019_eng.pdf

 

Metzner, R., & Leary, T. (1967). On programming psychedelic experiences. Psychedelic Review, 9, 5-19. https://maps.org/research-archive/psychedelicreview/n09/n09005met.pdf

 

Mikuriya, T., & Mandel, J. (2001). Cannabis substitution: Harm reduction treatment for alcoholism and drug dependence. https://www.mikuriya.com/cw_cansub.html

 

Mikuriya, T. H. (2004). Cannabis as a substitute for alcohol: A harm-reduction approach. Journal of Cannabis Therapeutics, 4(1), 79-93. https://doi.org/10.1300/J175v04n01_04

 

Miller, B. (2021). Does cannabis cause psychosis? Psychiatric Times, 38(3). https://www.psychiatrictimes.com/view/cannabis-cause-psychosis

 

Misiak, B., Stramecki, F., Gawęda, Ł., Prochwicz, K., Sąsiadek, M.M., Moustafa, A.A., & Frydecka, D. (2018). Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: A systematic review. Molecular Neurobiology, 55(6), 5075–5100. https://doi.org/10.1007/s12035-017-0708-y

 

Moran, C. (1986). Depersonalization and agoraphobia associated with marijuana use. British Journal of Medical Psychology, 59(2), 187-196. https://doi.org/10.1111/j.2044-8341.1986.tb02684.x

 

Mueser, K. T., Drake, R. E., & Wallach, M. A. (1998). Dual diagnosis: A review of etiological theories. Addictive Behaviors, 23(6), 717-734. https://doi.org/10.1016/S0306-4603(98)00073-2

 

Mundell, E., J. (2020). One joint may cause psychotic symptoms: Study. A Family Pharmacy Apple Valley. https://www.afamilypharmacy.com/patient-resources/article/755848/one-joint-may-cause-psychotic-symptoms-study

 

Muntoni, A. L., Pillolla, G., Melis, M., Perra, S., Gessa, G. L., & Pistis, M. (2006). Cannabinoids modulate spontaneous neuronal activity and evoked inhibition of locus coeruleus noradrenergic neurons. European Journal of Neuroscience, 23(9), 2385-2394. https://doi.org/10.1111/j.1460-9568.2006.04759.x

 

Naliboff, B. D., Rickles, W. H., Cohen, M. J., & Naimark, R. S. (1976). Interactions of marijuana and induced stress: Forearm blood flow, heart rate, and skin conductance. Psychophysiology, 13(6), 517-522. https://doi.org/10.1111/j.1469-8986.1976.tb00871.x

 

Ogborne, A. C., Smart, R. G., Weber, T., & Birchmore-Timney, C. (2000). Who is using cannabis as a medicine and why: An exploratory study. Journal of Psychoactive Drugs, 32(4), 435-443. https://doi.org/10.1080/02791072.2000.10400245

 

O'Shea, M., McGregor, I. S., & Mallet, P. E. (2006). Repeated cannabinoid exposure during perinatal, adolescent or early adult ages produces similar long lasting deficits in object recognition and reduced social interaction in rats. Journal of Psychopharmacology (Oxford), 20(5), 611-621. https://doi.org/10.1177/0269881106065188

 

O'Shea, M., Singh, M. E., McGregor, I. S., & Mallet, P. E. (2004). Chronic cannabinoid exposure produces lasting memory impairment and increased anxiety in adolescent but not adult rats. Journal of Psychopharmacology (Oxford), 18(4), 502-508. https://doi.org/10.1177/0269881104047277

 

Ortiz-Medina, M. B., Perea, M., Torales, J., Ventriglio, A., Vitrani, G., Aguilar, L., & Roncero, C. (2018). Cannabis consumption and psychosis or schizophrenia development. The International Journal of Social Psychiatry, 64(7), 690-703. https://doi.org/10.1177/0020764018801690

 

Passie, T., Emrich, H. M., Karst, M., Brandt, S. D., & Halpern, J. H. (2012). Mitigation of post‐traumatic stress symptoms by cannabis resin: A review of the clinical and neurobiological evidence. Drug Testing and Analysis, 4(7-8), 649-659. https://doi.org/10.1002/dta.1377

 

Patel, S., & Hillard, C. J. (2006). Pharmacological evaluation of cannabinoid receptor ligands in a mouse model of anxiety: Further evidence for an anxiolytic role for endogenous cannabinoid signaling. The Journal of Pharmacology and Experimental Therapeutics, 318(1), 304–311. https://doi.org/10.1124/jpet.106.101287

 

Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., and Holmes, A. (2017). The endocannabinoid system as a target for novel anxiolytic drugs. Neuroscience and Biobehavioral Reviews, 76(Pt A), 56–66. https://doi.org/10.1016/j.neubiorev.2016.12.033

 

Pertwee, R. G. (2008). The diverse cb1 and cb2 receptor pharmacology of three plant cannabinoids: Δ9‐tetrahydrocannabinol, cannabidiol and Δ9‐tetrahydrocannabivarin. British Journal of Pharmacology, 153(2), 199-215. https://doi.org/10.1038/sj.bjp.0707442

 

Pierre, J. M. (2010). Psychosis associated with medical marijuana: Risk vs. benefits of medicinal cannabis use. The American Journal of Psychiatry, 167(5), 598-599. https://doi.org/10.1176/appi.ajp.2010.09121762

 

Price, C., Tomas, H., Lewis, G., Zammit, S., & Allebeck, P. (2009). Cannabis and suicide: Longitudinal study. The British Journal of Psychiatry, 195(6), 492-497. https://doi.org/10.1192/bjp.bp.109.065227

 

Proal, A. C., Fleming, J., Galvez-Buccollini, J. A., & DeLisi, L. E. (2014). A controlled family study of cannabis users with and without psychosis. Schizophrenia Research, 152(1), 283–288; https://doi.org/10.1016/j.schres.2013.11.014

 

Rabinak, C. A., Blanchette, A., Zabik, N. L., Peters, C., Marusak, H. A., Iadipaolo, A., & Elrahal, F. (2020). Cannabinoid modulation of corticolimbic activation to threat in trauma-exposed adults: A preliminary study. Psychopharmacology, 237(6), 1813-1826. https://doi.org/10.1007/s00213-020-05499-8

 

Radhakrishnan, R., Wilkinson, S. T., D'Souza, D. C. (2014). Gone to pot—A review of the association between cannabis and psychosis. Frontiers in Psychiatry, 5, 54. https://doi.org/10.3389/fpsyt.2014.00054

 

Raymundi, A. M., da Silva, T. R., Sohn, J. M. B., Bertoglio, L. J., & Stern, C. A. (2020). Effects of ∆ 9 -tetrahydrocannabinol on aversive memories and anxiety: A review from human studies. BMC Psychiatry, 20(1), 420-17. https://doi.org/10.1186/s12888-020-02813-8

 

Reilly, D., Didcott, P., Swift, W., & Hall, W. (1998). Long‐term cannabis use: Characteristics of users in an australian rural area. Addiction (Abingdon, England), 93(6), 837-846. https://doi.org/10.1046/j.1360-0443.1998.9368375.x

 

Reiman, A. (2007). Medical cannabis patients: Patient profiles and health care utilization patterns. Complementary Health Practice Review, 12(1), 31-50. https://doi.org/10.1177/1533210107301834

 

Reiman, A. (2009). Cannabis as a substitute for alcohol and other drugs. Harm Reduction Journal, 6(1), 35-35. https://doi.org/10.1186/1477-7517-6-35

 

Rey, J. M., & Tennant, C. C. (2002). Cannabis and mental health: More evidence establishes clear link between use of cannabis and psychiatric illness. BMJ (Clinical Research ed.), 325(7374), 1183-1184. https://doi.org/10.1136/bmj.325.7374.1183

 

Ringen, P. A., Vaskinn, A., Sundet, K., Engh, J. A., Jonsdottir, H., Simonsen, C., Friis, S., Opjordsmoen, S., Melle, I., & Andreassen, O. A. (2010). Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia. Psychological Medicine, 40(8), 1337-1347. https://doi.org/10.1017/S0033291709991620

 

Roy-Byrne, P. P., & Uhde, T. W. (1988). Exogenous factors in panic disorder: clinical and research implications. The Journal of Clinical Psychiatry, 49(2), 56-61. https://pubmed.ncbi.nlm.nih.gov/3276668/

 

Rubino, T., Sala, M., Viganò, D., Braida, D., Castiglioni, C., Limonta, V., Guidali, C., Realini, N., & Parolaro, D. (2007). Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Δ9-tetrahydrocannabinol in rats. Neuropsychopharmacology, 32(9), 2036–2045. https://doi.org/10.1038/sj.npp.1301330

 

Rup, J., Freeman, T. P., Perlman, C., & Hammond, D. (2021). Cannabis and mental health: Prevalence of use and modes of cannabis administration by mental health status. Addictive Behaviors, 121, 106991. https://doi.org/10.1016/j.addbeh.2021.106991

 

Russo, E. B., Guy, G. W., & Robson, P. J. (2007). Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of sativex®, a cannabis‐based medicine. Chemistry & Biodiversity, 4(8), 1729-1743. https://doi.org/10.1002/cbdv.200790150

 

Safe ways to consume cannabis for people with anxiety. (2020). Green Rush Daily. https://greenrushdaily.com/guides/safest-ways-to-consume-cannabis-for-people-with-anxiety/

 

Sagar, K. A., Dahlgren, M. K., Racine, M. T., Dreman, M. W., Olson, D. P., & Gruber, S. A. (2016). Joint effects: A pilot investigation of the impact of bipolar disorder and marijuana use on cognitive function and mood. PLoS One, 11(6), e0157060. https://doi.org/10.1371/journal.pone.0157060

 

Sansone, R. A., & Sansone, L. A. (2014). Marijuana and body weight. Innovations in Clinical Neuroscience, 11(7-8), 50-54. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204468/

 

Savundranayagam, M. Y., & Sager, Z. S. (2021). The experiences, benefits, and harms of cannabis use in later life. Clinical Gerontologist, 44(1), 1-2. https://doi.org/10.1080/07317115.2020.1855131

 

Schierenbeck, T., Riemann, D., Berger, M., & Hornyak, M. (2008). Effect of illicit recreational drugs upon sleep: Cocaine, ecstasy and marijuana. Sleep Medicine Reviews, 12(5), 381-389. https://doi.org/10.1016/j.smrv.2007.12.004

 

Schizophrenia Working Group of the Psychiatric Genomics. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511, 421–427. https://doi.org/10.1038/nature13595

 

Semple, D. M., McIntosh, A. M., & Lawrie, S. M. (2005). Cannabis as a risk factor for psychosis: Systematic review. Sage Publicationshttps://doi.org/10.1177/0269881105049040

 

Set and setting: How they affect cannabis experience. (2019). 3 Leaf Edibles. https://www.3leafedibles.com/set-and-setting/

 

Shannon, S., Lewis, N., Lee, H., & Hughes, S.(2019). Cannabidiol in anxiety and sleep: A large case series. Permanente Journal, 23, 18-041.https://doi.org/10.7812/TPP/18-041

 

Šikić, J.( 2020). Cbd fights schizophrenia, but with different dose range for different symptoms. Ilesol Pharmaceuticals. https://ilesol.com/cbd-schizophrenia-symptoms/

 

Spalletta, G., Bria, P., & Caltagirone, C. (2007). Differences in temperament, character and psychopathology among subjects with different patterns of cannabis use. Psychopathology, 40(1), 29–34. https://doi.org/10.1159/000096387

 

Statistics Canada. (2015). Section b-Anxiety disordershttps://www150.statcan.gc.ca/n1/pub/82-619-m/2012004/sections/sectionb-eng.htm

 

Stoner, S. (2017). Effects of marijuana on mental health: Bipolar disorder. Alcohol & Drug Abuse Institute, University of Washington. http://adai.uw.edu/pubs/pdf/2017mjbipolar.pdf.

 

Studies from washington university yield new information about marijuana/cannabis (A large-scale genome-wide association study meta-analysis of cannabis use disorder). (2021). Psychology & Psychiatry Journal, 503https://link.gale.com/apps/doc/A646718700/AONE?u=humber&sid=summon&xid=bc33d18f

 

Subbaraman, M. S. (2014). Can cannabis be considered a substi-tute medication for alcohol? Alcohol and Alcoholism (Oxford), 49(3), 292–298. https://doi.org/10.1093/alcalc/agt182

 

Szoke, A., Galliot, A., Richard, J., Ferchiou, A., Baudin, G., Leboyer, M., & Schürhoff, F. (2014). Association between cannabis use and schizotypal dimensions –A meta-analysis of cross-sectional studies. Psychiatry Research, 219(1), 58-66. https://doi.org/10.1016/j.psychres.2014.05.008

 

Szuster, R. R., Pontius, E. B., & Campos, P. E. (1988). Marijuana sensitivity and panic anxiety. The Journal of Clinical Psychiatry, 49(11), 427-429. https://pubmed.ncbi.nlm.nih.gov/3182732/

 

Tambaro, S., & Bortolato, M. (2012). Cannabinoid-related agents in the treatment of anxiety disorders: Current knowledge and future perspectives. Recent Patents on CNS Drug Discovery, 7(1), 25-40. https://doi.org/10.2174/157488912798842269

 

Taylor, B., & Rehm, J. (2005). J-shape or linear relationship between alcohol consumption and depression: Does it matter? Addiction (Abingdon, England), 100(6), 871-872. https://doi.org/10.1111/j.1360-0443.2005.01062.x

 

Thomas, H. (1993). Psychiatric symptoms in cannabis users. The British Journal of Psychiatry, 163(2), 141-149. https://doi.org/10.1192/bjp.163.2.141

 

Thomas, H. (1996). A community survey of adverse effects of cannabis use. Drug and Alcohol Dependence, 42(3), 201-207. https://doi.org/10.1016/s0376-8716(96)01277-x

 

Torres, F. (2020). What is depression? American Psychiatric Association. https://www.psychiatry.org/patients-families/depression/what-is-depression

 

Torres, F. (2020). What is posttraumatic stress disorder?American Psychiatric Association. https://www.psychiatry.org/patients-families/ptsd/what-is-ptsd

 

Tournier, M., Sorbara, F., Gindre, C., Swendsen, J. D., & Verdoux, H. (2003). Cannabis use and anxiety in daily life: a naturalistic investigation in a non-clinical population. Psychiatry Research, 118(1), 1-8. https://doi.org/10.1016/s0165-1781(03)00052-0

 

Troisi, A., Pasini, A., Saracco, M., & Spalletta, G. (1998). Psychiatric symptoms in male cannabis users not using other illicit drugs. Addiction (Abingdon, England), 93(4), 487–492. https://doi.org/10.1046/j.1360-0443.1998.9344874.x

 

Tunving, K. (1987). Psychiatric aspects of cannabis use in adolescents and young adults. Pediatrician, 14(1-2), 83-91. https://pubmed.ncbi.nlm.nih.gov/3497393/

 

Turna, J., Patterson, B., and Van Ameringen, M. (2017). Is cannabis treatment for anxiety, mood, and related disorders ready for prime time? Depression and Anxiety, 34(11), 1006–1017. https://doi.org/10.1002/da.22664

 

Ullman, S. E., Relyea, M., Peter-Hagene, L., & Vasquez, A. L. (2013). Trauma histories, substance use coping, ptsd, and problem substance use among sexual assault victims. Addictive Behaviors, 38(6), 2219-2223. https://doi.org/10.1016/j.addbeh.2013.01.027

 

Vann, R. E., Gamage, T. F., Warner, J. A., Marshall, E. M., Taylor, N. L., Martin, B. R., & Wiley, J. L. (2008). Divergent effects of cannabidiol on the discriminative stimulus and place conditioning effects of Δ9-tetrahydrocannabinol. Drug and Alcohol Dependence, 94(1-3), 191-198. https://doi.org/10.1016/j.drugalcdep.2007.11.017

 

van Os, J., Bak, M., Hanssen, M., Bijl, R., De Graaf, R., & Verdoux, H. (2002). Cannabis use and psychosis: A longitudinal population-based study. American Journal of Epidemiology, 156(4), 319–327. https://doi.org/10.1093/aje/kwf043

 

Veteran Affairs Canada. (2020). Cannabis for medical purposeshttps://www.veterans.gc.ca/eng/about-vac/research/research-directorate/publications/reports/cmp

 

Viveros, M. P., Marco, E. M., & File, S. E. (2005). Endocannabinoid system and stress and anxiety responses. Pharmacology Biochemistry and Behavior, 81(2), 331-342. https://doi.org/10.1016/j.pbb.2005.01.029

 

Walsh, Z., Gonzalez, R., Crosby, K., Thiessen, M. S., Carroll, C., & Bonn-Miller, M. O. (2017). Medical cannabis and mental health: A guided systematic review. Clinical Psychology Review, 51, 15-29. https://doi.org/10.1016/j.cpr.2016.10.002

 

Webb, C. W., & Webb, S. M. (2014). Therapeutic benefits of cannabis: A patient survey. Hawai'i Journal of Medicine & Public Health, 73(4), 109-111. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998228/

 

Witkin, J. M., Tzavara, E. T., & Nomikos, G. G. (2005). A role for cannabinoid cb1 receptors in mood and anxiety disorders. Behavioural Pharmacology, 16(5–6), 315–331. https://doi.org/10.1097/00008877-200509000-00005

 

World Health Organization. (2016). The health and social effects of nonmedical cannabis use. https://apps.who.int/iris/handle/10665/251056

 

World Health Organization. (2019). Schizophrenia. Key facts. https://www.who.int/news-room/fact-sheets/detail/schizophrenia

 

Zinberg, N. E. (1984). Drug, set, and setting: The basis for controlled intoxicant use. Yale University Press. 

 

Zuardi, A. W., Shirakawa, I., Finkelfarb, E., & Karniol, I. G. (1982). Action of cannabidiol on the anxiety and other effects produced by Δ 9-thc in normal subjects. Psychopharmacology, 76(3), 245-250. https://doi.org/10.1007/BF00432554

 

Zvolensky, M. J., Bernstein, A., Marshall, E. C., & Feldner, M. T. (2006). Panic attacks, panic disorder, and agoraphobia: Associations with substance use, abuse, and dependence. Current Psychiatry Reports, 8(4), 279-285. https://doi.org/10.1007/s11920-006-0063-6

 

Zvolensky, M. J., Bonn-Miller, M. O., Bernstein, A., McLeish, A. C., Feldner, M. T., &  Leen-Feldner, E. W. (2006). Anxiety sensitivity interacts with marijuana use in the prediction of anxiety symptoms and panic-related catastrophic thinking among daily tobacco users. Behaviour Research and Therapy, 44(7), 907–924. https://doi.org/10.1016/j.brat.2005.06.005

 

Ashton, C. H. (2001). Pharmacology and effects of cannabis: A brief review. The British Journal of Psychiatry, 178(2), 101-106. https://doi.org/10.1192/bjp.178.2.101

 

Aurora. (n.d.). What to do if you green out. https://www.auroramedical.com/blogs/news/what-to-do-if-you-green-out

 

Brust, J. C. (1993). Other agents. Phencyclidine, marijuana, hallucinogens, inhalants, and anticholinergics. Neurologic Clinics, 11(3), 555-561. https://pubmed.ncbi.nlm.nih.gov/8377742/

 

Canadian Nurses Association. (2017). Harm reduction for non-medical cannabis use. https://hl-prod-ca-oc-download.s3-ca-central-1.amazonaws.com/CNA/2f975e7e-4a40-45ca-863c-5ebf0a138d5e/UploadedImages/documents/Harm_Reduction_for_Non_Medical_Cannabis_Use.pdf

 

Cao, D., Srisuma, S., Bronstein, A. C., & Hoyte, C. O. (2016). Characterization of edible marijuana product exposures reported to united states poison centers. Clinical Toxicology, 54(9), 840-846. https://doi.org/10.1080/15563650.2016.1209761

 

Centers for Disease Control and Prevention. (2009). Inadvertent ingestion of marijuana-los angeles, california, 2009. MMWR: Morbidity and Mortality Weekly Report, 58(34), 947-950. https://pubmed.ncbi.nlm.nih.gov/19730407/

 

Crippa, J. A., Derenusson, G. N., Chagas, M. H., Atakan, Z., Martín-Santos, R., Zuardi, A. W., & Hallak, J. E. (2012). Pharmacological interventions in the treatment of the acute effects of cannabis: A systematic review of literature. Harm reduction journal, 9(1), 7. https://doi.org/10.1186/1477-7517-9-7

 

Crippa, J. A., Zuardi, A. W., Martín‐Santos, R., Bhattacharyya, S., Atakan, Z., McGuire, P., & Fusar‐Poli, P. (2009). Cannabis and anxiety: A critical review of the evidence. Human Psychopharmacology: Clinical and Experimental, 24(7), 515-523. https://doi.org/10.1002/hup.1048

 

CSSDP. (2018). Sensible cannabis education - A toolkit for educating youth. https://cssdp.org/uploads/2018/04/Sensible-Cannabis-Education-A-Toolkit-for-Educating-Youth.pdf

 

Dalgarno, P., & Shewan, D. (2005). Reducing the risks of drug use: The case for set and setting. Addiction Research & Theory, 13(3), 259-265. https://doi.org/10.1080/16066350500053562

 

Egan, K. L., Cox, M. J., Suerken, C. K., Reboussin, B. A., Song, E. Y., Wagoner, K. G., & Wolfson, M. (2019). More drugs, more problems? Simultaneous use of alcohol and marijuana at parties among youth and young adults. Drug and Alcohol Dependence, 202, 69-75. https://doi.org/10.1016/j.drugalcdep.2019.07.003

 

Government of Canada. (2019). Cannabis: Lower your riskshttps://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/resources/loWer-your-risks.html

 

Grotenhermen, F. (2003). Pharmacokinetics and pharmacodynamics of cannabinoids. Clinical Pharmacokinetics, 42(4), 327-360. https://doi.org/10.2165/00003088-200342040-00003

 

Grotenhermen, F. (2007). The toxicology of cannabis and cannabis prohibition. Chemistry & Biodiversity, 4(8), 1744-1769. https://doi.org/10.1002/cbdv.200790151

 

Guidet, C., Gregoire, M., Le Dreau, A., Vrignaud, B., Deslandes, G., & Monteil-Ganière, C. (2020). Cannabis intoxication after accidental ingestion in infants: Urine and plasma concentrations of Δ-9-tetrahydrocannabinol (thc), thc-cooh and 11-oh-thc in 10 patients. Clinical Toxicology (Philadelphia, Pa.), 58(5), 421-423. https://doi.org/10.1080/15563650.2019.1655569

 

Hammond, D. (2019). Communicating thc levels and ‘dose’ to consumers: implications for product labelling and packaging of cannabis products in regulated markets. International Journal of Drug Policy, 91, 102509. https://doi.org/10.1016/j.drugpo.2019.07.004

 

Hand, A., Blake, A., Kerrigan, P., Samuel, P., & Friedberg, J. (2016). History of medical cannabis. Journal of Pain Management, 9(4), 387-394. https://www.researchgate.net/publication/316545890_History_of_medical_cannabis

 

Hartogsohn, I. (2017). Constructing drug effects: A history of set and setting. Drug Science, Policy and Law, 3. https://doi.org/10.1177/2050324516683325

 

Hendrickson, R. G., McKeown, N. J., Kusin, S. G., & Lopez, A. M. (2020). Acute cannabis toxicity in older adults. Toxicology Communications, 4(1), 67-70. https://doi.org/10.1080/24734306.2020.1852821

 

Hudak, M., Severn, D., & Nordstrom, K. (2015). Edible cannabis–induced psychosis: Intoxication and beyond. American Journal of Psychiatry, 172(9), 911-912. https://doi.org/10.1176/appi.ajp.2015.15030358

 

Huestis, M. A. (2007). Human cannabinoid pharmacokinetics. Chemistry & Biodiversity, 4(8), 1770–1804. https://doi.org/10.1002/cbdv.200790152

 

Levene, R. J., Pollak-Christian, E., & Wolfram, S. (2019). A 21st century problem: Cannabis toxicity in a 13-month-old child. The Journal of Emergency Medicine, 56(1), 94-96. https://doi.org/10.1016/j.jemermed.2018.09.040

 

Levinsohn, E. A., & Hill, K. P. (2020). Clinical uses of cannabis and cannabinoids in the united states. Journal of the Neurological Sciences, 411, 116717. https://doi.org/10.1016/j.jns.2020.116717

 

MacCallum, C. A., & Russo, E. B. (2018). Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine, 49, 12-19. https://doi.org/10.1016/j.ejim.2018.01.004

 

Molly, C., Mory, O., Basset, T., & Patural, H. (2012). Acute cannabis poisoning in a 10-month-old infant. Archives de pediatrie: Organe Officiel de la Societe Francaise de Pediatrie, 19(7), 729-732. https://doi.org/10.1016/j.arcped.2012.04.018

 

Murphy, K. (2017). “Greening out” Treating cannabis-related problems in the ed. Nursing Made Incredibly Easy!, 15(6), 47-50. https://doi.org/10.1097/01.NME.0000521808.84893.e7

 

Nickel J. C. (2018). Medical marijuana for urologic chronic pelvic pain. Canadian Urological Association Journal, 12(6 Suppl 3), S181–S183. https://doi.org/10.5489/cuaj.5331

 

Noble, M. J., Hedberg, K., & Hendrickson, R. G. (2019). Acute cannabis toxicity. Clinical Toxicology (Philadelphia, Pa.), 57(8), 735-742. https://doi.org/10.1080/15563650.2018.1548708

 

Richards, J. R., Smith, N. E., & Moulin, A. K. (2017). Unintentional cannabis ingestion in children: A systematic review. The Journal of Pediatrics, 190, 142-152. https://doi.org/10.1016/j.jpeds.2017.07.005

 

Rock, E. M., Bolognini, D., Limebeer, C. L., Cascio, M. G., Anavi-Goffer, S., Fletcher, P. J., Mechoulam, R., Pertwee, R. G., & Parker, L. A. (2013). Cannabidiol, a non-intoxicating component of cannabis, suppresses nausea and vomiting in rats and shrews. University of Guelph, Institute for Community Engaged Scholarshiphttps://atrium.lib.uoguelph.ca/xmlui/bitstream/handle/10214/5491/Parker%20-%20Cannibidiol%20a%20non-psychotropic%20component.pdf?sequence=3

 

Rough, L. (2020). 8 ways to sober up from being high. Leafly. https://www.leafly.ca/news/cannabis-101/8-ways-to-counteract-a-too-intense-cannabis-high

 

Sachs, J., McGlade, E., & Yurgelun-Todd, D. (2015). Safety and toxicology of cannabinoids. Neurotherapeutics : The Journal of the American Society for Experimental NeuroTherapeutics, 12(4), 735–746. https://doi.org/10.1007/s13311-015-0380-8

 

Saez, A. (n.d.). How much weed is too much? 7 signs you’re greening out and how to handle it. The Bluntness. https://www.thebluntness.com/posts/signs-you-re-greening-out-and-how-to-handle-it

 

Schlag, A. K., Hindocha, C., Zafar, R., Nutt, D. J., & Curran, H. V. (2021). Cannabis based medicines and cannabis dependence: A critical review of issues and evidence. Journal of Psychopharmacology (Oxford, England), 35(7), 773-785. https://doi.org/10.1177/0269881120986393

 

Schmid, Y., Scholz, I., Mueller, L., Exadaktylos, A. K., Ceschi, A., Liechti, M. E., & Liakoni, E. (2020). Emergency department presentations related to acute toxicity following recreational use of cannabis products in switzerland. Drug and Alcohol Dependence, 206, 107726. https://doi.org/10.1016/j.drugalcdep.2019.107726

 

Sharpe, L., Sinclair, J., Kramer, A., de Manincor, M., & Sarris, J. (2020). Cannabis, a cause for anxiety? A critical appraisal of the anxiogenic and anxiolytic properties. Journal of Translational Medicine, 18(1), 374. https://doi.org/10.1186/s12967-020-02518-2

 

Shen, L. (2021). Greening out explained–and what to do when you do go green. Cannabis Life Network. https://cannabislifenetwork.com/greening-out-explained-and-what-to-do-when-you-do-go-green/

 

Shewan, D., Dalgarno, P., & Reith, G. (2000). Perceived risk and risk reduction among ecstasy users: The role of drug, set, and setting. International Journal of Drug Policy, 10(6), 431-453. https://doi.org/10.1016/S0955-3959(99)00038-9

 

Venkatesan,T., Levinthal, D. J., Li, B. U., Tarbell, S. E., Adams, K. A., Issenman, R. M., Sarosiek, I., Jaradeh, S. S., Sharaf, R. N., Sultan, S., Stave, C. D., Monte, A. A., & Hasler, W. L. (2019). Role of chronic cannabis use: Cyclic vomiting syndrome vs cannabinoid hyperemesis syndrome. Neurogastroenterology and Motility, 31(S2). https://doi.org/10.1111/nmo.13606

 

Vo, K. T., Horng, H., Li, K., Ho, R. Y., Wu, A. H., Lynch, K. L., & Smollin, C. G. (2018). Cannabis intoxication case series: The dangers of edibles containing tetrahydrocannabinol. Annals of Emergency Medicine, 71(3), 306-313. https://doi.org/10.1016/j.annemergmed.2017.09.008

 

Voser, S. (2020). What is greening out and how to avoid it. Canna Connection. https://www.cannaconnection.com/blog/18321-what-greening-out-how-prevent-solve-it

 

Wang, G. S., Banerji, S., Contreras, A. E., & Hall, K. E. (2020). Marijuana exposures in colorado, reported to regional poison centre, 2000–2018. Injury Prevention, 26(2), 184-186. https://doi.org/10.1136/injuryprev-2019-043360

 

Wang, T., Collet, J. P., Shapiro, S., & Ware, M. A. (2008). Adverse effects of medical cannabinoids: A systematic review. CMAJ : Canadian Medical Association Journal, 178(13), 1669–1678. https://doi.org/10.1503/cmaj.071178

 

Weinstein, L. C., & Worster, B. (2019). Medical Cannabis: A guide to the clinical and legal landscapes. The Journal of Family Practice, 68(7), 390-399. https://pubmed.ncbi.nlm.nih.gov/31532813/

 

Zinberg, N. E. (1984). Drug, set and setting: The basis for controlled intoxicant use. JAMA (1985), 253(10), 1467. https://doi.org/10.1001/jama.1985.03350340121039

 

Acion, L., Ramirez, M. R., Jorge, R. E., & Arndt, S. (2013). Increased risk of alcohol and drug use among children from deployed military families. Addiction, 108(8), 1418–1425. https://doi.org/10.1111/add.12161

 

Ahmadi, H., & Green, S. L. (2011). Screening, brief intervention, and referral to treatment for military spouses experiencing alcohol and substance use disorders: A literature review. Journal of Clinical Psychology in Medical Settings, 18(2), 129-136. https://doi.org/10.1007/s10880-011-9234-7

 

Arkes, J. (2007). Does the economy affect teenage substance use? Health Economics, 16(1), 19–36. https://doi.org/10.1002/hec.1132

 

Arkes, J. (2011). Recessions and the participation of youth in the selling and use of illicit drugs. International Journal of Drug Policy, 22(5), 335–340. https://doi.org/10.1016/j.drugpo.2011.03.001

 

Attar, B. K., Guerra, N. G., & Tolan, P. H. (1994). Neighborhood disadvantage, stressful life events and adjustments in urban elementary-school children. Journal of Clinical Child Psychology, 23(4), 391–400. https://doi.org/10.1207/s15374424jccp2304_5

 

Ayer, L. A., Harder, V. S., Rose, G. L., & Helzer, J. E. (2011). Drinking and stress: An examination of sex and stressor differences using ivr-based daily data. Drug and Alcohol Dependence, 115(3), 205–212. https://doi.org/10.1016/j.drugalcdep.2010.10.022

 

Bachman, J. G., Freedman-Doan, P., O’Malley, P. M., Johnston, L. D., & Segal, D. R. (1999). Changing patterns of drug use among us military recruits before and after enlistment. American Journal of Public Health (1971), 89(5), 672–677. https://doi.org/10.2105/AJPH.89.5.672

 

Baker, C. K., Hishinuma, E. S., Chang, J. Y., & Nixon, D. C. (2010). The relationship among exposure to stressful life events, drug use, and violence perpetration in a sample of native hawaiian, samoan, and filipino adolescents. Journal of Interpersonal Violence25(3), 379–399. https://doi.org/10.1177/0886260509334397

 

Boardman, J. D., Finch, B. K., Ellison, C. G., Williams, D. R., & Jackson, J. S. (2001). Neighborhood disadvantage, stress, and drug use among adults. Journal of Health and Social Behavior, 42(2), 151–165. https://doi.org/10.2307/3090175

 

Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2014). Associations between exposure to stressful life events and alcohol use disorder in a longitudinal birth cohort studied to age 30. Drug and Alcohol Dependence, 142, 154–160. https://doi.org/10.1016/j.drugalcdep.2014.06.010

 

Bolton, J. M., Robinson, J., & Sareen, J. (2009). Self-medication of mood disorders with alcohol and drugs in the national epidemiologic survey on alcohol and related conditions. Journal of Affective Disorders, 115(3), 367–375. https://doi.org/10.1016/j.jad.2008.10.003

 

Bonin, M. F., McCreary, D. R., & Sadava, S. W. (2000). Problem drinking behavior in two community-based samples of adults: Influence of gender, coping, loneliness, and depression. Psychology of Addictive Behaviors, 14(2), 151-161. https://doi.org/10.1037/0893-164X.14.2.151

 

Booth, B., Segal, M. W., Bell, D. B., Martin, J. A., Ender, M. G., & Rohall, D. (2007). What we know about army families. Fairfax, VA: Caliber. 

 

Bor, J., Basu, S., Coutts, A., McKee, M., & Stuckler, D. (2013). Alcohol use during the great recession of 2008–2009. Alcohol and Alcoholism (Oxford), 48(3), 343–348. https://doi.org/10.1093/alcalc/agt002

 

Boscarino, J. A., Adams, R. E., & Galea, S. (2006). Alcohol use in new york after the terrorist attacks: a study of the effects of psychological trauma on drinking behavior. Addictive Behaviors, 31(4), 606–621. https://doi.org/10.1016/j.addbeh.2005.05.035

 

Bretteville-Jensen, A. L. (2011). Illegal drug use and the economic recession—What can we learn from the existing research? International Journal of Drug Policy, 22(5), 353–359. https://doi.org/10.1016/j.drugpo.2011.03.009

 

Brown, P. J., & Wolfe, J. (1994). Substance abuse and post-traumatic stress disorder comorbidity. Drug and Alcohol Dependence, 35(1), 51–59. https://doi.org/10.1016/0376-8716(94)90110-4

 

Bruguera, P., Reynolds, J., Gilvarry, E., Braddick, F., Marath-Veettil, A. L., Anderson, P., Mielecka-Kubien, Z., Kaner, E., & Gual, A. (2018). How does economic recession affect substance use? A reality check with clients of drug treatment centres. The Journal of Mental Health Policy and Economics, 21(1), 11–16. https://pubmed.ncbi.nlm.nih.gov/29643264/

 

Cappell, H., & Greeley, J. (1987). Alcohol and tension reduction: An update on research and theory. In H. T. Blane & K. E. Leonard (Eds.), Psychological theories of drinking and alcoholism New York: The Guilford Press. 

 

Carliner, H., Keyes, K. M., McLaughlin, K. A., Meyers, J. L., Dunn, E. C., & Martins, S. S. (2016). Childhood trauma and illicit drug use in adolescence: A population-based national comorbidity survey replication–adolescent supplement study. Journal of the American Academy of Child & Adolescent Psychiatry, 55(8), 701–708. https://doi.org/10.1016/j.jaac.2016.05.010

 

Catalano, R., Goldman-Mellor, S., Saxton, K., Margerison-Zilko, C., Subbaraman, M., LeWinn, K., & Anderson, E. (2011). The health effects of economic decline. Annual Review of Public Health, 32, 431–450. https://doi.org/10.1146/annurev-publhealth-031210-101146

 

Chatterjee, D. (2020). The mellow high and the psychedelic war: The rise of marijuana, the (counter)-culture of dissidence, and the fall of the american army in the vietnam war. eSharp, 25(1). https://www.researchgate.net/publication/340454299_The_Mellow_High_and_the_Psychedelic_War

 

Colder, C. R. (2001). Life stress, physiological and subjective indexes of negative emotionality, and coping reasons for drinking: Is there evidence for a self-medication model of alcohol use? Psychology of Addictive Behaviors, 15(3), 237-245. https://doi.org/10.1037/0893-164X.15.3.237

 

Colell, E., Sánchez‐Niubò, A., Delclos, G. L., Benavides, F. G., & Domingo‐Salvany, A. (2015). Economic crisis and changes in drug use in the spanish economically active population. Addiction (Abingdon, England), 110(7), 1129–1137. https://doi.org/10.1111/add.12923

 

Compton, W. M., Gfroerer, J., Conway, K. P., & Finger, M. S. (2014). Unemployment and substance outcomes in the united states 2002–2010. Drug and Alcohol Dependence, 142, 350–353. https://doi.org/10.1016/j.drugalcdep.2014.06.012

 

Darke, S. (2013). Pathways to heroin dependence: Time to re‐appraise self‐medication. Addiction (Abingdon, England), 108(4), 659–667. https://doi.org/10.1111/j.1360-0443.2012.04001.x

 

Darke, S., Williamson, A., Ross, J., & Teesson, M. (2005). Attempted suicide among heroin users: 12-month outcomes from the australian treatment outcome study (atos). Drug and Alcohol Dependence, 78(2), 177–186. https://doi.org/10.1016/j.drugalcdep.2004.10.009

 

Dávalos, M. E., Fang, H., & French, M. T. (2012). Easing the pain of an economic downturn: Macroeconomic conditions and excessive alcohol consumption. Health Economics21(11), 1318–1335. https://doi.org/10.1002/hec.1788

 

Dawson, D. A., Grant, B. F., & Ruan, W. J. (2005). The association between stress and drinking: Modifying effects of gender and vulnerability. Alcohol and Alcoholism (Oxford, Oxfordshire), 40(5), 453–460. https://doi.org/10.1093/alcalc/agh176

 

Dee, T. S. (2001). Alcohol abuse and economic conditions: Evidence from repeated cross‐sections of individual‐level data. Health Economics, 10(3), 257–270. https://doi.org/10.1002/hec.588

 

de Goeij, M. C. M., Suhrcke, M., Toffolutti, V., van de Mheen, D., Schoenmakers, T. M., & Kunst, A. E. (2015). How economic crises affect alcohol consumption and alcohol-related health problems: A realist systematic review. Social Science & Medicine (1982), 131, 131–146. https://doi.org/10.1016/j.socscimed.2015.02.025

 

Deutsch, H. (1967). Selected problems of adolescence. International Universities Press, New York. 

 

Dom, G., Samochowiec, J., Evans-Lacko, S., Wahlbeck, K., Van Hal, G., & McDaid, D. (2016). The impact of the 2008 economic crisis on substance use patterns in the countries of the European Union. International Journal of Environmental Research and Public Health13(1), 122. https://doi.org/10.3390/ijerph13010122

 

Dore, G., Mills, K., Murray, R., Teesson, M., & Farrugia, P. (2012). Post‐traumatic stress disorder, depression and suicidality in inpatients with substance use disorders. Drug and Alcohol Review, 31(3), 294–302. https://doi.org/10.1111/j.1465-3362.2011.00314.x

 

Dube, S. R., Miller, J. W., Brown, D. W., Giles, W. H., Felitti, V. J., Dong, M., & Anda, R. F. (2006). Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence. Journal of Adolescent Health, 38(4), 444.e1-444.e10. https://doi.org/10.1016/j.jadohealth.2005.06.006

 

DuBois, D. L., Felner, R. D., Meares, H., & Krier, M. (1994). Prospective investigation of the effects of socioeconomic disadvantage, life stress, and social support on early adolescent adjustment. Journal of Abnormal Psychology, 103(3), 511-522. https://doi.org/10.1037/0021-843X.103.3.511

 

Ehring, T., & Quack, D. (2010). Emotion regulation difficulties in trauma survivors: The role of trauma type and ptsd symptom severity. Behavior Therapy, 41(4), 587–598. https://doi.org/10.1016/j.beth.2010.04.004

 

Enoch, M. A. (2011). The role of early life stress as a predictor for alcohol and drug dependence. Psychopharmacology, 214(1), 17–31. https://doi.org/10.1007/s00213-010-1916-6

 

Ettner, S. L. (1997). Measuring the human cost of a weak economy: Does unemployment lead to alcohol abuse? Social Science & Medicine (1982), 44(2), 251–260. https://doi.org/10.1016/S0277-9536(96)00160-8

 

Falba, T., Teng, H., Sindelar, J. L., & Gallo, W. T. (2005). The effect of involuntary job loss on smoking intensity and relapse. Addiction (Abingdon, England), 100(9), 1330–1339. https://doi.org/10.1111/j.1360-0443.2005.01150.x

 

Farris, C. A., & Fenaughty, A. M. (2002). Social isolation and domestic violence among female drug users. The American Journal of Drug and Alcohol Abuse, 28(2), 339–351. https://doi.org/10.1081/ADA-120002977

 

Flett, R. A., Kazantzis, N., Long, N. R., MacDonald, C., & Millar, M. (2002). Traumatic events and physical health in a new zealand community sample. Journal of Traumatic Stress15(4), 303–312. https://doi.org/10.1023/A:1016251828407

 

Fosnocht, A. Q., Lucerne, K. E., Ellis, A. S., Olimpo, N. A., & Briand, L. A. (2019). Adolescent social isolation increases cocaine seeking in male and female mice. Behavioural Brain Research, 359, 589–596. https://doi.org/10.1016/j.bbr.2018.10.007

 

Fu, S. S., McFall, M., Saxon, A. J., Beckham, J. C., Carmody, T. P., Baker, D. G., & Joseph, A. M. (2007). Post-traumatic stress disorder and smoking: A systematic review. Nicotine & Tobacco Research, 9(11), 1071–1084. https://doi.org/10.1080/14622200701488418

 

Goodwin, D. W., Davis, D. H., & Robins, L. N. (1975). Drinking amid abundant illicit drugs: The Vietnam case. Archives of General Psychiatry, 32(2), 230–233. https://doi.org/10.1001/archpsyc.1975.01760200094009

 

Hall, W., & Weier, M. (2017). Lee robins’ studies of heroin use among us vietnam veterans. Addiction (Abingdon, England), 112(1), 176–180. https://doi.org/10.1111/add.13584

 

Hamilton, S. B., van Mouwerik, S., Oetting, E. R., Beauvais, F., & Keilin, W. G. (1988). Nuclear war as a source of adolescent worry: Relationships with age, gender, traitemotionality, and drug use. The Journal of Social Psychology, 128(6), 745–763. https://doi.org/10.1080/00224545.1988.9924554

 

Hammarström, A., Janlert, U., & Theorell, T. (1988). Youth unemployment and ill health: Results from a 2-year follow-up study. Social Science & Medicine (1982), 26(10), 1025–1033. https://doi.org/10.1016/0277-9536(88)90220-1

 

Hammer, T. (1992). Unemployment and use of drug and alcohol among young people: A longitudinal study in the general population. British Journal of Addiction, 87(11), 1571–1581. https://doi.org/10.1111/j.1360-0443.1992.tb02665.x

 

Harrell, A. (1992). Drugs, crime, and social isolation: Barriers to urban opportunity. The Urban Institute. 

 

Henkel, D. (2011). Unemployment and substance use: A review of the literature (1990-2010). Current Drug Abuse Reviews, 4(1), 4–27. https://doi.org/10.2174/1874473711104010004

 

Hoffmann, J. P., & Su, S. S. (1997). The conditional effects of stress on delinquency and drug use: A strain theory assessment of sex differences. Journal of Research in Crime and Delinquency, 34(1), 46–78. https://doi.org/10.1177/0022427897034001004

 

House, J. S., Landis, K. R., & Umberson, D. (1988). Social relationships and health. Science (New York, N.Y.), 241(4865), 540–545. https://doi.org/10.1126/science.3399889

 

Johnson, B. R., Pagano, M. E., Lee, M. T., & Post, S. G. (2018). Alone on the inside: The impact of social isolation and helping others on aod use and criminal activity. Youth & Society50(4), 529–550. https://doi.org/10.1177/0044118X15617400

 

Kalousova, L., & Burgard, S. A. (2014). Unemployment, measured and perceived decline of economic resources: Contrasting three measures of recessionary hardships and their implications for adopting negative health behaviors. Social Science & Medicine, 106, 28–34. https://doi.org/10.1016/j.socscimed.2014.01.007

 

Kelsall, H. L., Wijesinghe, M. S. D., Creamer, M. C., McKenzie, D. P., Forbes, A. B., Page, M. J., & Sim, M. R. (2015). Alcohol use and substance use disorders in gulf war, afghanistan, and iraq war veterans compared with nondeployed military personnel. Epidemiologic Reviews, 37(1), 38–54. https://doi.org/10.1093/epirev/mxu014

 

Keyes, K. M., Hatzenbuehler, M. L., & Hasin, D. S. (2011). Stressful life experiences, alcohol consumption, and alcohol use disorders: The epidemiologic evidence for four main types of stressors. Psychopharmacology, 218(1), 1–17. https://doi.org/10.1007/s00213-011-2236-1

 

Khan, S., Murray, R. P., & Barnes, G. E. (2002). A structural equation model of the effect of poverty and unemployment on alcohol abuse. Addictive Behaviors, 27(3), 405–423. https://doi.org/10.1016/s0306-4603(01)00181-2

 

Khantzian, E. J. (2013). Addiction as a self‐regulation disorder and the role of self‐medication. Addiction (Abingdon, England), 108(4), 668–669. https://doi.org/10.1111/add.12004

 

Kilpatrick, D. G., Acierno, R., Resnick, H. S., Saunders, B. E., & Best, C. L. (1997). A 2-year longitudinal analysis of the relationships between violent assault and substance use in women. Journal of Consulting and Clinical Psychology, 65(5), 834-837. https://doi.org/10.1037/0022-006X.65.5.834

 

King, A. C., Bernardy, N. C., & Hauner, K. (2003). Stressful events, personality, and mood disturbance:: Gender differences in alcoholics and problem drinkers. Addictive Behaviors28(1), 171–187. https://doi.org/10.1016/S0306-4603(01)00264-7

 

Lee, J. O., Hill, K. G., Hartigan, L. A., Boden, J. M., Guttmannova, K., Kosterman, R., Bailey, J. A., & Catalano, R. F. (2015). Unemployment and substance use problems among young adults: Does childhood low socioeconomic status exacerbate the effect? Social Science & Medicine (1982), 143, 36–44. https://doi.org/10.1016/j.socscimed.2015.08.016

 

Lemke, S., Schutte, K. K., Brennan, P. L., & Moos, R. H. (2008). Gender differences in social influences and stressors linked to increased drinking. Journal of Studies on Alcohol and Drugs, 69(5), 695–702. https://doi.org/10.15288/jsad.2008.69.695

 

Lijffijt, M., Hu, K., & Swann, A. C. (2014). Stress modulates illness-course of substance use disorders: A translational review. Frontiers in Psychiatry, 5, 83. https://doi.org/10.3389/fpsyt.2014.00083

 

McAloney, K., McCrystal, P., Percy, A., & McCartan, C. (2009). Damaged youth: Prevalence of community violence exposure and implications for adolescent well‐being in post‐conflict Northern Ireland. Journal of Community Psychology, 37(5), 635–648. https://doi.org/10.1002/jcop.20322

 

Miller, N. S., Mahler, J. C., & Gold, M. S. (1991). Suicide risk associated with drug and alcohol dependence. Journal of Addictive Diseases, 10(3), 49–61. https://doi.org/10.1300/J069v10n03_06

 

Mulia, N., Ye, Y., Zemore, S. E., & Greenfield, T. K. (2008). Social disadvantage, stress, and alcohol use among black, hispanic, and white americans: Findings from the 2005 us national alcohol survey. Journal of Studies on Alcohol and Drugs, 69(6), 824–833. https://doi.org/10.15288/jsad.2008.69.824

 

Myers, B., McLaughlin, K. A., Wang, S., Blanco, C., & Stein, D. J. (2014). Associations between childhood adversity, adult stressful life events, and past-year drug use disorders in the national epidemiological study of alcohol and related conditions (nesarc). Psychology of Addictive Behaviors, 28(4), 1117-1126. https://doi.org/10.1037/a0037459

 

Nagelhout, G. E., Hummel, K., de Goeij, M. C. M., de Vries, H., Kaner, E., & Lemmens, P. (2017). How economic recessions and unemployment affect illegal drug use: A systematic realist literature review. International Journal of Drug Policy, 44, 69–83. https://doi.org/10.1016/j.drugpo.2017.03.013

 

Nandi, A., Charters, T. J., Strumpf, E. C., Heymann, J., & Harper, S. (2013). Economic conditions and health behaviours during the ‘great recession.’. Journal of Epidemiology and Community Health (1979), 67(12), 1038–1046. https://doi.org/10.1136/jech-2012-202260

 

Ngo, H. M., & Le, T. N. (2007). Stressful life events, culture, and violence. Journal of Immigrant and Minority Health, 9(2), 75–84. https://doi.org/10.1007/s10903-006-9018-6

 

Ornish, D. (1998). Love & survival: The scientific basis for the healing power of intimacy and love. Rocco Publishing Company. 

 

Pelissier, B. M. M., & O’Neil, J. A. (2000). Antisocial personality and depression among incarcerated drug treatment participants. Journal of Substance Abuse, 11(4), 379–393. https://doi.org/10.1016/S0899-3289(00)00034-1

 

Pilowsky, D. J., Keyes, K. M., & Hasin, D. S. (2009). Adverse childhood events and lifetime alcohol dependence. American Journal of Public Health (1971), 99(2), 258–263. https://doi.org/10.2105/AJPH.2008.139006

 

Rardin, D. R., Lawson, T. R., & Rush Jr, J. A. (1973). Drug use by american soldiers in europe. Social Work (New York), 18(1), 34–41. https://doi.org/10.1093/sw/18.1.34

 

Raz, S., & Berger, B. D. (2010). Social isolation increases morphine intake: Behavioral and psychopharmacological aspects. Behavioural Pharmacology, 21(1), 39–46. https://doi.org/10.1097/FBP.0b013e32833470bd

 

Reed, S. C., Bell, J. F., & Edwards, T. C. (2011). Adolescent well-being in washington state military families. American Journal of Public Health (1971), 101(9), 1676–1682. https://doi.org/10.2105/AJPH.2011.300165

 

Ritter, A., & Chalmers, J. (2011). The relationship between economic conditions and substance use and harm. Drug and Alcohol Review, 30(1), 1–3. https://doi.org/10.1111/j.1465-3362.2010.00282.x

 

Robins, L. N. (1974). The Vietnam drug user returns: Final report, September 1973. US Government Printing Office. 

 

Robins, L. N., Davis, D. H., & Nurco, D. N. (1974). How permanent was vietnam drug addiction? American Journal of Public Health (1971), 64 Suppl 12(12_Suppl), 38–43. https://doi.org/10.2105/AJPH.64.12_Suppl.38

 

Rokach, A. (2000). Loneliness and the life cycle. Psychological Reports, 86(2), 629–642. https://doi.org/10.2466/PR0.86.2.629-642

 

Rokach, A., & Orzeck, T. (2003). Coping with loneliness and drug use in young adults. Social Indicators Research, 61(3), 259–283. https://doi.org/10.1023/A:1021977731756

 

Rospenda, K. M., Fujishiro, K., Shannon, C. A., & Richman, J. A. (2008). Workplace harassment, stress, and drinking behavior over time: Gender differences in a national sample. Addictive Behaviors, 33(7), 964–967. https://doi.org/10.1016/j.addbeh.2008.02.009

 

Rossi, D., Singh, D. Z., Pawlowicz, M. P., Touzé, G., Bolyard, M., Mateu-Gelabert, P., Sandoval, M., & Friedman, S. R. (2011). Changes in time-use and drug use by youngadults in poor neighbourhoods of greater buenos aires, argentina, after the political transitions of 2001-2002: Results of a survey. Harm Reduction Journal, 8(1), 2. https://doi.org/10.1186/1477-7517-8-2

 

Schiff, M. (2006). Living in the shadow of terrorism: Psychological distress and alcohol use among religious and non-religious adolescents in jerusalem. Social Science & Medicine (1982), 62(9), 2301–2312. https://doi.org/10.1016/j.socscimed.2005.10.016

 

Schiff, M., Benbenishty, R., McKay, M., DeVoe, E., Liu, X., & Hasin, D. (2006). Exposure to terrorism and israeli youths’ psychological distress and alcohol use: An exploratory study. American Journal on Addictions, 15(3), 220–226. https://doi.org/10.1080/10550490600626200

 

Schiff, M., Pat-Horenczyk, R., Benbenishty, R., Brom, D., Baum, N., & Astor, R. A. (2012). High school students’ posttraumatic symptoms, substance abuse and involvement in violence in the aftermath of war. Social Science & Medicine (1982), 75(7), 1321–1328. https://doi.org/10.1016/j.socscimed.2012.05.010

 

Schiff, M., Zweig, H. H., Benbenishty, R., & Hasin, D. S. (2007). Exposure to terrorism and israeli youths’ cigarette, alcohol, and cannabis use. American Journal of Public Health (1971), 97(10), 1852–1858. https://doi.org/10.2105/AJPH.2006.090514

 

Shedler, J., & Block, J. (1990). Adolescent drug use and psychological health: A longitudinal inquiry. American Psychologist, 45(5), 612-630. https://doi.org/10.1037/0003-066X.45.5.612

 

Sinha, R. (2001). How does stress increase risk of drug abuse and relapse? Psychopharmacology158(4), 343–359. https://doi.org/10.1007/s002130100917

 

Sinha, R. (2008). Chronic stress, drug use, and vulnerability to addiction. Annals of the New York Academy of Sciences, 1141(1), 105-130. https://doi.org/10.1196/annals.1441.030

 

Skaff, M. M., Finney, J. W., & Moos, R. H. (1999). Gender differences in problem drinking and depression: Different “vulnerabilities?” American Journal of Community Psychology27(1), 25–54. https://doi.org/10.1023/A:1022813727823

 

Slopen, N., Williams, D. R., Fitzmaurice, G. M., & Gilman, S. E. (2011). Sex, stressful life events, and adult onset depression and alcohol dependence: Are men and women equally vulnerable? Social Science & Medicine (1982), 73(4), 615–622. https://doi.org/10.1016/j.socscimed.2011.06.022

 

Stanton, M. D. (1976). Drugs, vietnam, and the vietnam veteran: an overview. The American Journal of Drug and Alcohol Abuse, 3(4), 557–570. https://doi.org/10.3109/00952997609014295

 

Steckler, T., Kalin, N. H., & Reul, J. M. H. M. (2005). Handbook of stress and the brain part 2: Stress: Integrative and clinical aspects. Elsevier. 

 

Stewart, S. H. (1996). Alcohol abuse in individuals exposed to trauma: A critical review. Psychological Bulletin, 120(1), 83-112. https://doi.org/10.1037/0033-2909.120.1.83

 

Stewart, S. H., & Israeli, A. L. (2002). Substance abuse and co-occurring psychiatric disorders in victims of intimate violence. In C. Wekerle & A. -M. Walls (Eds.), The violence and addiction equation: Theoretical and clinical issues in substance abuse and relationship violence (pp. 98-122). Brunner-Routledge. 

 

Ullman, S. E., Relyea, M., Peter-Hagene, L., & Vasquez, A. L. (2013). Trauma histories, substance use coping, ptsd, and problem substance use among sexual assault victims. Addictive Behaviors, 38(6), 2219–2223. https://doi.org/10.1016/j.addbeh.2013.01.027

 

Veenstra, M. Y., Lemmens, P. H. H. M., Friesema, I. H. M., Tan, F. E. S., Garretsen, H. F. L., Knottnerus, J. A., & Zwietering, P. J. (2007). Coping style mediates impact of stress on alcohol use: A prospective population‐based study. Addiction (Abingdon, England)102(12), 1890–1898. https://doi.org/10.1111/j.1360-0443.2007.02026.x

 

Whitaker, L. R., Degoulet, M., & Morikawa, H. (2013). Social deprivation enhances vta synaptic plasticity and drug-induced contextual learning. Neuron, 77(2), 335–345. https://doi.org/10.1016/j.neuron.2012.11.022

 

Winton, M., Heather, N., & Robertson, I. (1986). Effects of unemployment on drinking behavior: A review of the relevant evidence. International Journal of the Addictions,21(12), 1261–1283. https://doi.org/10.3109/10826088609074854

 

Wish, E. D., Robins, L. N., Hesselbrock, M., & Helzer, J. E. (1979). The course of alcohol problems in vietnam veterans. Currents in Alcoholism, 6, 239-256. https://pubmed.ncbi.nlm.nih.gov/520054/

 

Youngstrom, E., Weist, M. D., & Albus, K. E. (2003). Exploring violence exposure, stress, protective factors and behavioral problems among inner‐city youth. American Journal of Community Psychology, 32(1–2), 115–129. https://doi.org/10.1023/A:1025607226122

 

Government of Canada. (2020). What you need to know about cannabishttps://www.canada.ca/en/services/health/campaigns/cannabis/canadians.html

 

Government of Canada. (2021). Authorized cannabis retailers in the provinces and territories. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/laws-regulations/provinces-territories.html

 

Hahn, R. A., Middleton, J. C., Elder, R., Brewer, R., Fielding, J., Naimi, T. S., Toomey, T. L., Chattopadhyay, S., Lawrence, B., Campbell, C. A., & Community Preventive Services Task Force. (2012). Effects of alcohol retail privatization on excessive alcohol consumption and related harms: A community guide systematic review. American Journal of Preventive Medicine, 42(4), 418-427. https://doi.org/10.1016/j.amepre.2012.01.002

 

How to read a label. (2020). Tweed. https://www.tweed.com/en/vault/articles/how-to-read-a-cannabis-label

 

Legal vs. Illegal: Inside canada’s marketplace. (2020). Responsible Cannabis Use. https://thercu.org/blogs/blog/legal-vs-illegal-inside-canada-s-cannabis-marketplace

 

Macdonald, A. (2018). Cannabis is now legal in canada! What is still illegal? (Part II). Right Legal https://www.rightlegal.ca/canada-cannabis-illegal-part2/

 

Myran, D. T., Chen, J. T., Giesbrecht, N., Rees, V. W. (2019). The association between alcohol access and alcohol-attributable emergency department visits in ontario, canada. Addiction (Abingdon, England), 114(7), 1183–1191. https://doi.org/10.1111/add.14597

 

Myran, D. T., Staykov, E., Cantor, N., Taljaard, M., Quach, B. I., Hawken, S., & Tanuseputro, P. (2021). How has access to legal cannabis changed over time? an analysis of the cannabis retail market in canada 2 years following the legalisation of recreational cannabis. Drug and Alcohol Review, 41(2), 377-385. https://doi.org/10.1111/dar.13351

 

Nunavut - Department of Finance. (2021). Cannabishttps://gov.nu.ca/finance/information/cannabis

 

Ontario. (2019). Buying recreational cannabishttps://www.ontario.ca/page/buying-recreational-cannabis

 

Ontario Cannabis Store. (2020). A Year in review-2019-2020: Ontario's first full year of legal cannabis operations. https://regulatorwatch.com/wp-content/uploads/2020/07/Cannabis-OCS-InsightsReport_2019-2020.pdf

 

Ontario Cannabis Store. (n.d.). Reading a cannabis labelhttps://ocs.ca/blogs/choosing-cannabis-products/reading-a-cannabis-product-label

 

Prince Edward Island. (2018). Cannabis policy, legislation and regulationhttps://www.princeedwardisland.ca/en/information/cannabis-policy-legislation-and-regulAtion

 

Rotermann, M. (2019). National cannabis survey 2nd quarter. Statistics Canada. https://www150.statcan.gc.ca/n1/en/catalogue/11-627-M2019057

 

Rotermann, M. (2021). Looking back from 2020, how cannabis use and related behaviours changed in canada. Health Reports, 32(4), 3-14. https://doi.org/10.25318/82-003-x202100400001-eng

 

Statistics Canada. (2019). The retail cannabis market in canada: A portrait of the first yearhttps://www150.statcan.gc.ca/n1/pub/11-621-m/11-621-m2019005-eng.htm

 

Wadsworth, E., Driezen, P., & Hammond, D. (2021). Retail availability and legal purchases of dried flower in canada post-legalization. Drug and Alcohol Dependence, 225, 108794. https://doi.org/10.1016/j.drugalcdep.2021.108794

 

Where can I buy recreational cannabis in canada? (2019). BudHubCanada. https://budhubcanada.ca/where-can-i-buy-legal-recreational-cannabis-in-canada/

 

Where to buy legal cannabis online in canada. (2020). Namaste. https://www.namaste.ca/blog/buy-marijuana-online-canada/

 

Alberta Health Services. (2020). Tobacco reduction programhttps://myhealth.alberta.ca/Alberta/Pages/Using-cannabis-and-tobacco-together.aspx

 

Alston, E. (2020). What happens when you mix xanax and marijuana. The Recovery Village. https://www.therecoveryvillage.com/xanax-addiction/xanax-and-weed/

 

Alston, L. (2021). Cbd and xanax: Can you take them together? CFAH. https://cfah.org/cbd-and-xanax/

 

Carter, A. (2019). What really happens when you mix alcohol and weed? Healthline. https://www.healthline.com/health/alcohol-and-weed

 

Christiansen, T. (2020). Can you mix weed and cocaine? The Recovery Village. https://www.therecoveryvillage.com/cocaine-addiction/cocaine-and-weed/

 

Dangers of combining marijuana and lsd. (2018). Skywood Recovery. https://skywoodrecovery.com/marijuana/dangers-of-combining-marijuana-and-lsd/

 

DeVito, L. (2017). Cb1 and cb2: Different cannabinoid receptors in the brain. LabRoots. https://www.labroots.com/trending/health-and-medicine/7420/cb1-cb2-cannabinoid-receptors-brain

 

Goodwin, R. D., Pacek, L. R., Copeland, J., Moeller, S. J., Dierker, L., Weinberger, A., Gbedemah, M., Zvolensky, M. J., Wall, M. M., & Hasin, D. S. (2018). Trends in daily cannabis use among cigarette smokers: United states, 2002–2014. American Journal of Public Health, 108(1), 137-142. https://doi.org/10.2105/AJPH.2017.304050

 

Haney, M., Bedi, G., Cooper, Z. D., Glass, A., Vosburg, S. K., Comer, S. D., & Foltin, R. W. (2013). Predictors of marijuana relapse in the human laboratory: Robust impact of tobacco cigarette smoking status. Biological Psychiatry (1969), 73(3), 242-248. https://doi.org/10.1016/j.biopsych.2012.07.028

 

Henry, J. A., Oldfield, W. L. G., & Kon, O. M. (2003). Comparing cannabis with tobacco: Smoking cannabis, like smoking tobacco, can be a major public health hazard. BMJ: British Medical Journal, 326(7396), 942-943. https://doi.org/10.1136/bmj.326.7396.942

 

Hindocha, C., Brose, L. S., Walsh, H., & Cheeseman, H. (2021). Cannabis use and co‐use in tobacco smokers and non‐smokers: Prevalence and associations with mental health in a cross‐sectional, nationally representative sample of adults in great britain, 2020. Addiction (Abingdon, England), 116(8), 2209-2219. https://doi.org/10.1111/add.15381

 

How do you look after someone who is ‘greening out’ on cannabis? ( 2014). Drug and Alcohol Research and Training Australia. https://darta.net.au/wordpress-content/uploads/2015/01/YPID-GREENING-OUT.pdf

 

Hutchison, S. (2021). The effects of mixing marijuana and ecstasy. River Oaks Treatment. https://riveroakstreatment.com/marijuana-abuse/mixing-with-ecstasy/

 

Isbell, H., & Jasinski, D. R. (1969). A comparison of lsd-25 with (-)-Δ9-trans-tetrahydrocannabinol (thc) and attempted cross tolerance between lsd and thc. Psychopharmacologia, 14(2), 115-123. https://doi.org/10.1007/BF00403684

 

Iversen, L. (2003). Cannabis and the brain. Brain (London, England : 1878), 126(6), 1252-1270. https://doi.org/10.1093/brain/awg143

 

Kossen, J. (2017). How does cannabis interact with other drugs? Leafly. https://www.leafly.ca/news/health/cannabis-cannabinoids-drug-interactions

 

LaNeve, N. (2021). Is it safe to mix alcohol & marijuana? The Recovery Village. https://www.therecoveryvillage.com/alcohol-abuse/alcohol-and-marijuana/

 

Martin, P., & Consroe, P. (1981). A preliminary study of thc-lsd interactions on rabbit eeg and behavior. Physiological Psychology, 9(2), 219-222. https://doi.org/10.3758/BF03332927

 

McClure, E. A., Rabin, R. A., Lee, D. C., & Hindocha, C. (2020). Treatment implications associated with cannabis and tobacco co-use. Current Addiction Reports, 7(4), 533-544. https://doi.org/10.1007/s40429-020-00334-8

 

McDaniel, B. (2020). Why mixing opioids and marijuana to treat chronic pain is dangerous? Asheville Recovery Center. https://www.ashevillerecoverycenter.com/why-mixing-opioids-and-marijuana-to-treat-chronic-pain-is-dangerous/

 

Melamede, R. (2005). Cannabis and tobacco smoke are not equally carcinogenic. Harm Reduction Journal, 2(1), 21. https://doi.org/10.1186/1477-7517-2-21

 

Meier, E., & Hatsukami, D. K. (2016). A review of the additive health risk of cannabis and tobacco co-use. Drug and Alcohol Dependence, 166, 6-12. https://doi.org/10.1016/j.drugalcdep.2016.07.013

 

Mixing marijuana with other drugs. (2020). Aspenridge Recovery. https://www.aspenridgerecoverycenters.com/mixing-marijuana-with-other-drugs/

 

Moke: What it is and why it is unhealthy for teens? ( 2018). Newport Academy. https://www.newportacademy.com/resources/substance-abuse/moke-drug-definition-and-risks/

 

National Institute on Drug Abuse. (2021). Cocaine drug facts. What is cocaine? https://www.drugabuse.gov/publications/drugfacts/cocaine

 

Pacek, L. R., Copeland, J., Dierker, L., Cunningham, C. O., Martins, S. S., & Goodwin, R. D. (2018). Among whom is cigarette smoking declining in the united states? The impact of cannabis use status, 2002–2015. Drug and Alcohol Dependence, 191, 355-360. https://doi.org/10.1016/j.drugalcdep.2018.01.040

 

Parrott, A. C., Milani, R. M., Gouzoulis-Mayfrank, E., & Daumann, J. (2007). Cannabis and ecstasy/mdma (3,4-methylenedioxymethamphetamine): An analysis of their neuropsychobiological interactions in recreational users. Journal of Neural Transmission, 114(8), 959-968. https://doi.org/10.1007/s00702-007-0715-7

 

Peters, E. N., Budney, A. J., & Carroll, K. M. (2012). Clinical correlates of co‐occurring cannabis and tobacco use: A systematic review. Addiction (Abingdon, England), 107(8), 1404-1417. https://doi.org/10.1111/j.1360-0443.2012.03843.x

 

Peters, E. N., Schwartz, R. P., Wang, S., O’Grady, K. E., & Blanco, C. (2014). Psychiatric, psychosocial, and physical health correlates of co-occurring cannabis use disorders and nicotine dependence. Drug and Alcohol Dependence, 134, 228-234. https://doi.org/10.1016/j.drugalcdep.2013.10.003

 

Rahn, B. (2015). Why does cannabis cause paranoia in some but helps anxiety in others? Leafly. https://www.leafly.ca/news/cannabis-101/why-does-cannabis-cause-paranoia-and-anxiety

 

Ramo, D. E., Liu, H., & Prochaska, J. J. (2012). Tobacco and marijuana use among adolescents and young adults: A systematic review of their co-use. Clinical Psychology Review, 32(2), 105-121. https://doi.org/10.1016/j.cpr.2011.12.002

 

Rettner, R. (2016). Mixing the pot? 7 ways marijuana interacts with medicines. LiveScience. https://www.livescience.com/56439-how-marijuana-interacts-with-medicines.html

 

Schauer, G. L., Berg, C. J., Kegler, M. C., Donovan, D. M., & Windle, M. (2015). Differences in tobacco product use among past month adult marijuana users and nonusers: Findings from the 2003–2012 national survey on drug use and Health. Nicotine & Tobacco Research, 18(3), 281-288. https://doi.org/10.1093/ntr/ntv093

 

Sidney, S., Beck, J. E., Tekawa, I. S., Quesenberry, C. P., & Friedman, G. D. (1997). Marijuana use and mortality. American Journal of Public Health, 87(4), 585-590. https://doi.org/10.2105/ajph.87.4.585

 

Singh, T., Kennedy, S. M., Sharapova, S. S., Schauer, G. L., & Rolle, I. V. (2016). Modes of ever marijuana use among adult tobacco users and non-tobacco users—styles 2014. Journal of Substance Use, 21(6), 631-635. https://doi.org/10.3109/14659891.2015.1122100

 

Statistics Canada. (2017). Canadian tobacco, alcohol and drugs survey. https://www.canada.ca/en/health-canada/services/canadian-alcohol-drugs-survey/2017-suMmary.html

 

Stephens, C. (2017). What should you know about hyperthermia? Medical News Today. https://www.medicalnewstoday.com/articles/320226

 

Tashkin, D. P., Baldwin, G. C., Sarafian, T., Dubinett, S., Roth, M. D. (2002). Respiratory and immunologic consequences of marijuana smoking. Journal of Clinical Pharmacology, 42(S1), 71S-81S. https://doi.org/10.1002/j.1552-4604.2002.tb06006.x

 

The dangers of mixing marijuana and cocaine. (2021). Vertava Health. https://vertavahealth.com/polysubstances/marijuana-and-cocaine/

 

Tucker, J. S., Pedersen, E. R., Seelam, R., Dunbar, M.S., Shih, R. A., & D'Amico, E. J. (2019). Types of cannabis and tobacco/nicotine co-use and associated outcomes in young adulthood. Psychology of Addictive Behaviors, 33(4), 401-411. https://doi.org/10.1037/adb0000464

 

United Nations Office on Drugs and Crime. (2019). World drug report 2019. https://wdr.unodc.org/wdr2019/

 

Wilcox, A. (2019). What happens to your body when you mix weed and tobacco? Herb. https://herb.co/learn/smoke-weed-and-tobacco/

 

Wilson, D., R. (2019). Is weed a depressant, stimulant, or hallucinogen? Healthline. https://www.healthline.com/health/is-weed-a-depressant

 

World Health Organization. (2020). Tobaccohttps://www.who.int/news-room/fact-sheets/detail/tobacco

 

Van der Kooy, F., Pomahacova, B., & Verpoorte, R. (2009). Cannabis smoke condensate II: Influence of tobacco on tetrahydrocannabinol levels. Inhalation Toxicology, 21(2), 87-90. https://doi.org/10.1080/08958370802187296

 

Abdallah, S. J., Smith, B. M., Ware, M. A., Moore, M., Li, P. Z., Bourbeau, J., & Jensen, D. (2018). Effect of vaporized cannabis on exertional breathlessness and exercise endurance in advanced chronic obstructive pulmonary disease: A randomized controlled trial. Annals of the American Thoracic Society, 15(10), 1146-1158. https://doi.org/10.1513/AnnalsATS.201803-198OC

 

Aldington, S., Williams, M., Nowitz, M., Weatherall, M., Pritchard, A., McNaughton, A., Robinson, G., & Beasley, R. (2007). Effects of cannabis on pulmonary structure,function and symptoms. Thorax, 62(12), 1058-1063. https://doi.org/10.1136/thx.2006.077081

 

Baczynsky, W. O., & Zimmerman, A. M. (1983a). Effects of Δ9-tetrahydrocannabinol, cannabinol and cannabidiol on the immune system in mice. I. In vivo investigation of the primary and secondary immune response. Pharmacology, 26(1), 12-19. https://doi.org/10.1159/000137763

 

Baczynsky, W. O., & Zimmerman, A. M. (1983b). Effects of Δ9-tetrahydrocannabinol, cannabinol and cannabidiol on the immune system in mice: II. In vitro investigation using cultured mouse splenocytes. Pharmacology, 26(1), 12-19. https://doi.org/10.1159/000137764

 

BC Lung Foundation. (2019). Cannabis and Lung Healthhttps://bclung.ca/how-we-can-help/cannabis-and-lung-health

 

Biles, M. (2019). Cannabis & the immune system: A complex balancing act. Project CBD. https://www.projectcbd.org/science/cannabis-and-immune-system

 

CDC. (2018). Marijuana and public health: Immune function. Centers for Disease Control and Prevention. https://www.cdc.gov/marijuana/nas/immune-function.html

 

Coggans, N., Dalgarno, P., Johnson, L., & Shewan, D. (2020). Long-term heavy cannabis use: Implications for health education. Drugs: Education Prevention and Policy, 11(4), 299-313. https://doi.org/10.108009687630410001687860

 

Croxford, J. L., & Yamamura, T. (2005). Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? Journal of Neuroimmunology, 166(1-2), 3–18. https://doi.org/10.1016/j.jneuroim.2005.04.023

 

Dax, E.M., Pilotte, N.S., Adler, W.H., Nagel, J.E., & Lange, W. R. (1989). The effects of 9-ene-tetrahydrocannabinol on hormone release and immune function. Journal of Steroid Biochemistry, 34(1-6), 263-270. https://doi.org/10.1016/0022-4731(89)90090-3

 

Earleywine, M., & Barnwell, S. S. (2007). Decreased respiratory symptoms in cannabis users who vaporize. Harm Reduction Journal, 4(11). https://doi.org/10.1186/1477-7517-4-11

 

Gates, P., Jaffe, A., & Copeland, J. (2014). Cannabis smoking and respiratory health: Consideration of the literature. Respirology, 19(5), 655-662. https://doi.org/10.1111/resp.12298

 

Hancox, R. J., Poulton, R., Ely, M., Welch, D., Taylor, D. R., McLachlan, C. R., Greene, J. M., Moffitt, T. E., Caspi, A., & Sears, M. R. (2010). Effects of cannabis on lung function: A population-based cohort study. The European Respiratory Journal, 35(1), 42–47. https://doi.org/10.1183/09031936.00065009

 

He, T., Oks, M., Esposito, M., Steinberg, H., & Makaryus, M. (2017). “Tree-in-bloom”: Severe acute lung injury induced by vaping cannabis oil. Annals of the American Thoracic Society, 14(3). https://doi.org/10.1513/AnnalsATS.201612-974LE

 

Hui-ChihWu, J. (2014). Evidence brief: Communicable disease impacts of sharing electronic-cigarettes with drip tips. Public Health Ontario. https://www.publichealthontario.ca/-/media/documents/eb-ecig-communicable-driptip.pdf?la=en

 

Joshi, M., Joshi, A., & Bartter, T. (2014). Marijuana and lung diseases. Current Opinion in Pulmonary Medicine, 20(2), 173-179. https://doi.org/10.1097/MCP.0000000000000026

 

Keen, L., 2nd, Abbate, A., Blanden, G., Priddie, C., Moeller, F. G., & Rathore, M. (2017). Confirmed marijuana use and lymphocyte count in black people living with hiv. Drug and Alcohol Dependence, 180, 22–25. https://doi.org/10.1016/j.drugalcdep.2017.07.026 (Retraction published Drug Alcohol Depend. 2019 May 1;198:199)

 

Klein, T. W., & Friedman, H. (1990). Modulation of murine immune cell function by marijuana components. In R. R. Watson (Ed.), Drugs of Abuse and Immune Function, (pp. 87-112). CRC Press. https://books.google.ca/books?hl=en&lr=&id=5ePEDE1-r5YC&oi=fnd&pg=PA87&dq=Klein+and+Friedman,+1990+immune&ots=_Jh7HBFTTJ&sig=hFM-xogPK0HMXqIPGhHtw5M0-hg#v=onepage&q=Klein%20and%20Friedman%2C%201990%20immune&f=false

 

Klein, T. W., Friedman, H., Specter, S. (1998, March 15). Marijuana, immunity, and infection. The Journal of Neuroimmunology, 83(1-2), 102-115. https://doi.org/10.1016/S0165-5728(97)00226-9

 

Klein, T. W., Newton, C., & Friedman, H. (1986). Inhibition of natural killer cell function by marijuana components. Journal of Toxicology and Environmental Health, 20(4), 321- 332. https://doi.org/10.1080/15287398709530986

 

Lee, M. H. S., & Hancox, R. J. (2011). Effects of smoking cannabis on lung function. Expert Review of Respiratory Medicine, 5(4), 537-547. https://doi.org/10.1586/ers.11.40

 

Marcellin, F., Lions, C., Rosenthal, E., Roux, P., Sogni, P., Wittkop, L., Protopopescu, C., Spire, B., Salmon-Ceron, D., Dabis, F., Carrieri, M. P., & HEPAVIH ANRS CO13 StudyGroup (2017). No significant effect of cannabis use on the count and percentage of circulating cd4 t-cells in hiv-hcv co-infected patients (anrs co13-hepavih french cohort). Drug and Alcohol Review, 36(2), 227–238. https://doi.org/10.1111/dar.12398

 

Martin, R., Safaee, S. D., Somsamouth, K., Mounivong, B., Sinclair, R., Bansal, S., & Singh,P. N. (2013). Mixed methods pilot study of sharing behaviors among waterpipe smokers of rural lao pdr: Implications for infectious disease transmission. International Journal of Environmental Research and Public Health, 10(6), 2120-2132. https://doi.org/10.3390/ijerph10062120

 

McInnis, O. A., & Plecas, D. (2016). Clearing the smoke on cannabis: Respiratory effects of cannabis smoking: An update. Canadian Centre on Substance Abuse. https://www.ccsa.ca/sites/default/files/2019-04/CCSA-Cannabis-Use-Respiratory-Effects-Report-2016-en.pdf

 

Michael G. DeGroote Centre for Medicinal Cannabis Research. (2018).What effects does smoking cannabis have on the respiratory system? McMaster University MDCMCR. https://cannabisresearch.mcmaster.ca/news/2018/04/27/cannabis-smoking-and-effects-on-the-respiratory-system

 

Molina, P. E., Amedee, A. M., LeCaptaine, N. J., Zabaleta, J., Mohan, M., Winsauer, J., Vande Stouwe, C., McGoey, R. R., Auten, M. W., LaMotte, L., Chandra, L. C., & Birke, L. L. (2014). Modulation of gut-specific mechanisms by chronic Δ9-tetrahydrocannabinol administration in male rhesus macaques infected with simian immunodeficiency virus: A systems biology analysis. AIDS Research and Human Retroviruses, 30(6), 567-578. https://doi.org/10.1089/aid.2013.0182

 

Molina, P. E., Winsauer, P., Zhang, P., Walker, E., Birke, L., Amedee, A., Stouwe, C. V., Troxclair, D., McGoey, R., Varner, K., Byerley, L., & LaMotte, L. (2011). Cannabinoid administration attenuates the progression of simian immunodeficiency virus. AIDS Research and Human Retroviruses, 27(6), 585–592. https://doi.org/10.1089/aid.2010.0218

 

Munckhof, W. J., Konstantinos, A., Wamsley, M., Mortlock, M., & Gilpin, C. (2003). A cluster of tuberculosis associated with use of a marijuana water pipe. The International Journal of Tuberculosis and Lung Disease, 7(9), 860–865. https://pubmed.ncbi.nlm.nih.gov/12971670/

 

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on the Health Effects of Marijuana: An Evidence Review and Research Agenda. (2017). The Health Effects of Cannabis and Cannabinoids: The Current State of Evidence and Recommendations for Research. Washington (DC): National Academies Press (US); 2017 Jan 12. https://doi.org/10.17226/24625

 

National Institute on Drug Abuse. (2019). What are marijuana's effects on lung health? https://nida.nih.gov/publications/research-reports/marijuana/what-are-marijuanas-effects-lung-health

 

Papatheodorou, S. I., Buettner, H., Rice, M. B., & Mittleman, M. A. (2016). Recent marijuana use and associations with exhaled nitric oxide and pulmonary function in adults in the united states. Chest, 149(6), 1428-1435. https://doi.org/10.1016/j.chest.2015.12.033

 

Patel, V., Borysenko, M., Kumar, M. S. A., & Millard, W.J. (1985). Effects of acute and subchronic Δ9-tetrahydrocannabinol administration on the plasma catecholamine, β-endorphin, and corticosterone levels and splenic natural killer cell activity in rats. Proceedings of the Society for Experimental Biology and Medicine, 180(2), 400–404. https://doi.org/10.3181/00379727-180-42195

 

Pletcher, M. J., Vittinghoff, E., Kalhan, R., Richman, J., Safford, M., Sidney, S., Lin, F., & Kertesz, S. (2012). Association between marijuana exposure and pulmonary function over 20 years. JAMA, 307(2), 173–181. https://doi.org/10.1001/jama.2011.1961

 

Ribeiro, L., & Ind, P. (2016). S127 effect of cannabis smoking on the development of bullous lung disease: A structured literature review. Thorax, 71, A74-A76. https://dx.doi.org/10.1136/thoraxjnl-2016-209333.133

 

Statistics Canada. (2018). Canadian tobacco, alcohol and drugs (ctads) survey: 2017 detailed tables. https://www.canada.ca/en/health-canada/services/canadian-tobacco-alcohol-drugs-survey/2017-summary/2017-detailed-tables.html#t16

 

Tan, W.C., Lo, C., Jong, A., Xing, L., FitzGerald, M.J., Vollmer, W.M., Buist, S.A., & Sin, D.D. (2009). Marijuana and chronic obstructive lung disease: A population-based study. CMAJ : Canadian Medical Association Journal, 180(8), 814-820. https://doi.org/10.1503/cmaj.081040

 

Tashkin, D.P. & Roth, M.D. (2019). Pulmonary effects of inhaled cannabis smoke. The American Journal of Drug and Alcohol Abuse, 45(6), 596-609. https://doi.org/10.1080/00952990.2019.1627366

 

Taylor, D. R., Fergusson, D. M., Milne, B. J., Horwood, L. J., Moffitt, T. E., Sears, M. R., & Poulton, R. (2002). A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults. Addiction (Abingdon, England), 97(8), 1055–1061. https://doi.org/10.1046/j.1360-0443.2002.00169.x

 

Tetrault, J.M., Crothers, K., Moore, B.A., Mehra, R., Concato, &  J., Fiellin, D.A. (2007). Effects of marijuana smoking on pulmonary function and respiratory complications: A systematic review. Archives of Internal Medicine, 167(3), 221–228. https://doi.org/10.1001/archinte.167.3.221

 

Thu, K., Hayes, M., Miles, S., Tierney, L., & Foy, A. (2013). Marijuana 'bong' smoking and tuberculosis. Internal Medicine Journal, 43(4), 456–458. https://doi.org/10.1111/imj.12089

 

Van Dam, N. T., & Earleywine, M. (2010). Pulmonary function in cannabis users: Support for a clinical trial of the vaporizer. International Journal on Drug Policy, 21(6), 511–513. https://doi.org/10.1016/j.drugpo.2010.04.001

 

Wu, T. C., Tashkin, D. P., Djahed, B., & Rose, J. E. (1988). Pulmonary hazards of smoking marijuana as compared with tobacco. The New England Journal of Medicine, 318(6), 347–351. https://doi.org/10.1056/NEJM198802113180603

 

Asbridge, M., Hayden, J. A., & Cartwright, J. L. (2012). Acute cannabis consumption and motor vehicle collision risk: Systematic review of observational studies and meta-analysis. BMJ (Online), 344, e536. https://doi.org/10.1136/bmj.e536 

 

Downey, L. A., King, R., Papafotiou, K., Swann, P., Ogden, E., Boorman, M., & Stough, C. (2013). The effects of cannabis and alcohol on simulated driving: Influences of dose and experience. Accident Analysis and Prevention, 50, 879-886. https://doi.org/10.1016/j.aap.2012.07.016 

 

Fischer, B., Jeffries, V., Hall, W., Room, R., Goldner, E., & Rehm, J. (2011). Lower risk cannabis use guidelines for canada (lrcug): A narrative review of evidence and recommendations. Canadian Journal of Public Health, 102(5), 324-327. https://doi.org/10.1007/BF03404169

 

Fischer, B., Russell, C., Sabioni, P., van den Brink, W., Le Foll, B., Hall, W., Rehm, J., & Room, R. (2017). Lower-risk cannabis use guidelines: A comprehensive update ofevidence and recommendations. American Journal of Public Health (1971), 107(8), E1-E12. https://doi.org/10.2105/AJPH.2017.303818 

 

Hall, W. (2018). How should we respond to cannabis‐impaired driving? Drug and Alcohol Review, 37(1), 3-5. https://doi.org/10.1111/dar.12651 

 

Hall, W., & Homel, R. (2007). [commentary] Reducing cannabis‐impaired driving: Is there sufficient evidence for drug testing of drivers? Addiction (Abingdon, England), 102(12), 1918-1919. https://doi.org/10.1111/j.1360-0443.2007.02042.x 

 

Jones, C. B., Meier, M. H., & Pardini, D. A. (2018). Comparison of the locations where young adults smoke, vape, and eat/drink cannabis: Implications for harm reduction. Addictive Behaviors Reports, 8, 140-146. https://doi.org/10.1016/j.abrep.2018.09.002

 

Lake, S., Kerr, T., Werb, D., Haines‐Saah, R., Fischer, B., Thomas, G., Walsh, Z., Ware, M. A., Wood, E., & Milloy, M. (2019). Guidelines for public health and safety metrics to evaluate the potential harms and benefits of cannabis regulation in canada. Drug and Alcohol Review, 38(6), 606-621. https://doi.org/10.1111/dar.12971  

 

Laumon, B., Gadegbeku, B., Martin, J., Biecheler, M., & SAM Group. (2005). Cannabis intoxication and fatal road crashes in france: Population based case-control study. BMJ331(7529), 1371-1374. https://doi.org/10.1136/bmj.38648.617986.1F 

 

Richer, I., & Bergeron, J. (2009). Driving under the influence of cannabis: Links with dangerous driving, psychological predictors, and accident involvement. Accident Analysis and Prevention, 41(2), 299-307. https://doi.org/10.1016/j.aap.2008.12.004 

 

Shiplo, S., Asbridge, M., Leatherdale, S. T., & Hammond, D. (2016). Medical cannabis use in canada: Vapourization and modes of delivery. Harm Reduction Journal, 13(1), 30-30. https://doi.org/10.1186/s12954-016-0119-9

 

Wettlaufer, A., Florica, R. O., Asbridge, M., Beirness, D., Brubacher, J., Callaghan, R., Fischer, B., Gmel, G., Imtiaz, S., Mann, R. E., McKiernan, A., & Rehm, J. (2017). Estimating the harms and costs of cannabis-attributable collisions in the canadian provinces. Drug and Alcohol Dependence, 173, 185-190. https://doi.org/10.1016/j.drugalcdep.2016.12.024

 

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596

 

Anthony, J. C, & Helzer, J. E. (1991). Syndromes of drug abuse and dependence. In Robins, L. N, & Regier, D. A. (eds). Psychiatric disorders in america. (pp. 116-154). New York. Free Press. McMillan.

 

Arendt, M., Rosenberg, R., Foldager, L., Perto, G., & Munk-Jørgensen, P. (2005). Cannabis-induced psychosis and subsequent schizophrenia-spectrum disorders: Follow-up study of 535 incident cases. British Journal of Psychiatry, 187(6), 510-515. https://doi.org/10.1192/bjp.187.6.510

 

Arkowitz, H., & Lilienfeld, S. (2021, March 1). Experts tell the truth about pot. Scientific American. https://www.scientificamerican.com/article/the-truth-about-pot/

 

Barnwell, S. S., Earleywine, M., & Wilcox, R. (2006). Cannabis, motivation, and life satisfaction in an internet sample. Substance Abuse Treatment, Prevention and Policy, 1(1), 2-2. https://doi.org/10.1186/1747-597X-1-2

 

Bloomfield, M. A. P., Morgan, C. J. A., Kapur, S., Curran, H. V., & Howes, O. D. (2014). The link between dopamine function and apathy in cannabis users: An [18f]-Dopa pet imaging study. Psychopharmacology, 231(11), 2251-2259. https://doi.org/10.1007/s00213-014-3523-4

 

Birchard, K. (2001). Cannabis weakens immune system, may cause mental illness: Cannabis today much more potent than in past. The Medical Post, 37(7), 59. https://www.proquest.com/trade-journals/cannabis-weakens-immune-system-may-cause-mental/docview/228747678/se-2?accountid=11530

 

Bryant, A. L., Schulenberg, J. E., O'Malley, P. M., Bachman, J. G., & Johnston, L. D. (2003). How academic achievement, attitudes, and behaviors relate to the course of substance use during adolescence: A 6-year, multiwave national longitudinal study. Journal of Research on Adolescence, 13(3), 361-397. https://doi.org/10.1111/1532-7795.1303005

 

Bryant, A. L., & Zimmerman, M. A. (2002). Examining the effects of academic beliefs and behaviors on changes in substance use among urban adolescents. Journal of Educational Psychology, 94, 621-637. https://doi.org/10.1037/0022-0663.94.3.621

 

Campolongo, P., Trezza, V., Cassano, T., Gaetani, S., Morgese, M. G., Ubaldi, M., Soverchia, L., Antonelli, T., Ferraro, L., Massi, M., Ciccocioppo, R., & Cuomo, V. (2007). Perinatal exposure to delta-9-tetrahydrocannabinol causes enduring cognitive deficits associated with alteration of cortical gene expression and neurotransmission in rats. Addiction Biology, 12(3). 485-495. https://doi.org/10.1111/j.1369-1600.2007.00074.x

 

Carney, R., Cotter, J., Firth, J., Bradshaw, T., & Yung, A. R. (2017). Cannabis use and symptom severity in individuals at ultra high risk for psychosis: A meta‐analysis. Acta Psychiatrica Scandinavica, 136(1), 5-15. https://doi.org/10.1111/acps.12699

 

Compton, D. R., Dewey, W. L., & Martin, B. R. (1990). Cannabis dependence and tolerance production. Advances in Alcohol & Substance Abuse, 9(1-2), 129-147. https://doi.org/10.1300/J251v09n01_08

 

Cox, R. G., Zhang, L., Johnson, W. D., & Bender, D. R. (2007). Academic performance and substance use: From a state survey of public high school students. Journal of School Health, 77(3), 109-115. https://doi.org/10.1111/j.1746-1561.2007.00179.x

 

Degenhardt, L., Chiu, W. T., Sampson, N., Kessler, R. C., Anthony, J. C. (2007). Epidemiological patterns of extra-medical drug use in the united states: Evidence from the national comorbidity survey replication, 2001–2003. Drug and Alcohol Dependence, 90(2), 210–23. https://doi.org/10.1016/j.drugalcdep.2007.03.007

 

Dreher, M. (2002). Crack heads and roots daughters: The therapeutic use of cannabis in jamaica. Journal of Cannabis Therapeutics, 2(3-4), 121-133. https://doi.org/10.1300/J175v02n03_08

 

Dryfoos, J. G. (1990). Adolescents at risk: Prevalence and prevention. New York: Oxford University Press. https://doi.org/10.1093/oso/9780195072686.001.0001

 

Duncan, D. F. (1987). Lifetime prevalence of “amotivational syndrome” among users and nonusers of hashish. Psychology of Addictive Behaviors, 1(2), 114-119. https://doi.org/10.1037/0893-164X.1.2.114

 

Farris, M. S., Shakeel, M. K., & Addington, J. (2020). Cannabis use in individuals at clinical high-risk for psychosis: A comprehensive review. Social Psychiatry and Psychiatric Epidemiology, 55(5), 527-537. https://doi.org/10.1007/s00127-019-01810-x

 

Fergusson, D. M., & Boden, J. M. (2008). Cannabis use and later life outcomes. Addiction (Abingdon, England), 103(6), 969-976. https://doi.org/10.1111/j.1360-0443.2008.02221.x

 

Fergusson, D. M., Horwood, L. J., & Beautrais, A. L. (2003). Cannabis and educational achievement. Addiction (Abingdon, England), 98(12), 1681–1692. https://doi.org/10.1111/j.1360-0443.2003.00573.x

 

Finn, K. V. (2012). Marijuana use at school and achievement-linked behaviors. The High School Journal, 95(3), 3-13. https://doi.org/10.1353/hsj.2012.0005

 

Freeman, T. P., & Winstock, A. R. (2015). Examining the profile of high-potency cannabis and its association with severity of cannabis dependence. Psychological Medicine, 45(15), 3181-3189. https://doi.org/10.1017/S0033291715001178

 

Gerard, A. (2014). Medical cannabis and the myth of amotivational syndrome. Substance Abuse Policy. https://substanceabusepolicy.biomedcentral.com/articles/10.1186/1747-597X-1-2

 

Grewal, J. K., & Loh, L. C. (2020). Health considerations of the legalization of cannabis edibles. Canadian Medical Association Journal (CMAJ), 192(1), E1-E2. https://doi.org/10.1503/cmaj.191217

 

Grewal, S., & George. T. (2017). Cannabis-induced psychosis: A review. Psychiatric Times, 34(7). https://www.psychiatrictimes.com/view/cannabis-induced-psychosis-review

 

Guimarães, F. S., Chiaretti, T. M., Graeff, F. G., and Zuardi, A. W. (1990). Antianxiety effect of cannabidiol in the elevated plus-maze. Psychopharmacology, 100(4), 558–559. https://doi.org/10.1007/BF02244012

 

Hall, W. (2015). What has research over the past two decades revealed about the adverse health effects of recreational cannabis use? Addiction (Abingdon, Endlang), 110(1), 19-35. https://doi.org/10.1111/add.12703

 

Hartney, E. (2021). Recognize the symptoms of marijuana addiction. VeryWellMind. https://www.verywellmind.com/characteristics-of-marijuana-addiction-22298

 

Hasin, D. S., O'Brien, C. P., Auriacombe, M., Borges, G., Bucholz, K., Budney, A., Compton, W. M., Crowley, T., Ling, W., Petry, N. M., Schuckit, M., & Grant, B. F. (2013). Dsm-5 criteria for substance use disorders: Recommendations and rationale. The American Journal of Psychiatry, 170(8), 834-851. https://doi.org/10.1176/appi.ajp.2013.12060782

 

Hasin, D. S., Saha, T. D., Kerridge, B. T., Goldstein, R. B., Chou, S. P., Zhang, H., Jung, J., Pickering, R. P., Ruan, W. J., Smith, S. M., Huang, B., & Grant, B. F. (2015). Prevalence of marijuana use disorders in the united states between 2001-2002 and 2012-2013. JAMA Psychiatry, 72(12), 1235-1242. https://doi.org/10.1001/jamapsychiatry.2015.1858

 

Hawkins, J. D., Catalano, R. F., & Miller, J. Y. (1992). Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: Implications for substance abuse prevention. Psychological Bulletin, 112(1), 64-105. https://doi.org/10.1037/0033-2909.112.1.64

 

Henry, K. L. (2010). Academic achievement and adolescent drug use: An examination of reciprocal effects and correlated growth trajectories. Journal of School Health, 80, 38-43. https://doi.org/10.1111/j.1746-1561.2009.00455.x

 

Jafari, S., & Tang, T. (2016). Diagnosis and treatment of marijuana dependence. British Columbia Medical Journal, 58(6), 315-317. https://bcmj.org/articles/diagnosis-and-treatment-marijuana-dependence

 

Joo, S. H., Durband, D. B., & Grable, J. (2008). The academic impact of financial stress on college students. Journal of College Student Retention: Research, Theory & Practice, 10(3), 287-305. https://doi.org/10.2190/CS.10.3.c

 

Kouri, E., Pope Jr, H. G., Yurgelun-Todd, D., & Gruber, S. (1995). Attributes of heavy vs. occasional marijuana smokers in a college population. Biological Psychiatry (1969), 38(7), 475-481. https://doi.org/10.1016/0006-3223(94)00325-W

 

Krumrei-Mancuso, E. J., Newton, F. B., Kim, E., & Wilcox, D. (2013). Psychosocial factors predicting first-year college student success. Journal of College Student Development, 54(3), 247-266. https://doi.org/10.1353/csd.2013.0034

 

Ksir, C., & Hart, C. L. (2016). Cannabis and psychosis: A critical overview of the relationship. Current Psychiatry Reports, 18(2), 1-11. https://doi.org/10.1007/s11920-015-0657-y

 

Lac, A., & Luk, J. W. (2018). Testing the amotivational syndrome: Marijuana use longitudinally predicts lower self-efficacy even after controlling for demographics, personality, and alcohol and cigarette use. Prevention Science, 19(2), 117-126. https://doi.org/10.1007/s11121-017-0811-3

 

Lachenmeier, D. W., & Rehm, J. (2015). Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach. Scientific Reports, 5(1), 8126. https://doi.org/10.1038/srep08126

 

Linscott, R. J., & van Os, J. (2013). An updated and conservative systematic review and meta-analysis of epidemiological evidence on psychotic experiences in children and adults: On the pathway from proneness to persistence to dimensional expression across mental disorders. Psychological Medicine, 43(6), 1133-1149. https://doi.org/10.1017/S0033291712001626

 

Lucas, P. (2012). Cannabis as an adjunct to or substitute for opiates in the treatment of chronic pain. Journal of Psychoactive Drugs, 44(2), 125-133. https://doi.org/10.1080/02791072.2012.684624

 

Lucas, P., Reiman, A., Earleywine, M., McGowan, S. K., Oleson, M., Coward, M. P., & Thomas, B. (2013). Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients. Addiction Research & Theory, 21(5), 435-442. https://doi.org/10.3109/16066359.2012.733465

 

Lynskey, M. T., & Hall, W. (2000). The effects of adolescent cannabis use on educational achievement: A review. Addiction (Abingdon, England), 95(11), 1621-1630. https://doi.org/10.1046/j.1360-0443.2000.951116213.x

 

Mattern, K. D., & Shaw, E. J. (2010). A look beyond cognitive predictors of academic success: Understanding the relationship between academic self-beliefs and outcomes. Journal of College Student Development, 51(6), 665-678. https://doi.org/10.1353/csd.2010.0017

 

Marconi, A., Di Forti, M., Lewis, C. M., Murray, R. M., & Vassos, E. (2016). Meta-analysis of the association between the level of cannabis use and risk of psychosis. Schizophrenia Bulletin, 42(5), 1262-1269. https://doi.org/10.1093/schbul/sbw003

 

Media Relations. (2017).  Marijuana use tied to poorer school performance. University of Waterloo. https://uwaterloo.ca/news/news/marijuana-use-tied-poorer-school-performance

 

Mikuriya, T. H. (2004). Cannabis as a substitute for alcohol: A harm-reduction approach. Journal of Cannabis Therapeutics, 4(1), 79-93. https://doi.org/10.1300/J175v04n01_04

 

Mikuriya, T., & Mandel, J. (2001). Cannabis substitution: Harm reduction treatment for alcoholism and drug dependence. https://www.mikuriya.com/cw_cansub.html

 

Miller, B. (2021). Does cannabis cause psychosis? Psychiatric Times, 38(3). https://www.psychiatrictimes.com/view/cannabis-cause-psychosis

 

Mundell, E., J. (2020). One joint may cause psychotic symptoms: Study. A Family Pharmacy Apple Valley. https://www.afamilypharmacy.com/patient-resources/article/755848/one-joint-may-cause-psychotic-symptoms-study

 

Musty, R. E., & Kaback, L. (1995). Relationships between motivation and depression in chronic marijuana users. Life Sciences, 56(23-24), 2151-2158. https://doi.org/10.1016/0024-3205(95)00202-h

 

Newcomb, M. D., Bentler, P. M. (1988). Impact of adolescent drug use and social support on problems of young adults: a longitudinal study. Journal of Abnormal Psychology (1965), 97(1), 64–75. https://doi.org/10.1037/0021-843X.97.1.64

 

Patton G. C., Coffey C., Lynskey M. T., Reid S., Hemphill S., Carlin J. B., & Hall, W. (2007). Trajectories of adolescent alcohol and cannabis use into young adulthood. Addiction (Abingdon, England), 102(4), 607–15. https://doi.org/10.1111/j.1360-0443.2006.01728.x

 

Petrucci, A. S., LaFrance, E. M., & Cuttler, C. (2020). A comprehensive examination of the links between cannabis use and motivation. Substance Use & Misuse, 55(7), 1155-1164. https://doi.org/10.1080/10826084.2020.1729203

 

Pike, G. R., Kuh, G. D., & Massa-McKinley, R. C. (2008). First-year students' employment, engagement, and academic achievement: Untangling the relationship between work and grades. NASPA Journal, 45(4), 560-582. https://doi.org/10.2202/1949-6605.2011

 

Radhakrishnan, R., Wilkinson, S. T., D'Souza, D. C. (2014). Gone to pot—A review of the association between cannabis and psychosis. Frontiers in Psychiatry, 5, 54. https://doi.org/10.3389/fpsyt.2014.00054

 

Ramo, D. E., Delucchi, K. L., Hall, S. M., Liu, H., & Prochaska, J. J. (2013). Marijuana and tobacco co-use in young adults: Patterns and thoughts about use. Journal of Studies on Alcohol and Drugs, 74(2), 301-310. https://doi.org/10.15288/jsad.2013.74.301

 

Register, C. A., Williams, D. R., & Grimes, P. W. (2001). Adolescent drug use and educational attainment. Education Economics, 9(1), 1-18. https://doi.org/10.1080/09645290124529

 

Reilly, D., Didcott, P., Swift, W., & Hall, W. (1998). Long‐term cannabis use: Characteristics of users in an australian rural area. Addiction (Abingdon, England), 93(6), 837-846. https://doi.org/10.1046/j.1360-0443.1998.9368375.x

 

Reiman, A. (2007). Medical cannabis patients: Patient profiles and health care utilization patterns. Complementary Health Practice Review, 12(1), 31-50. https://doi.org/10.1177/1533210107301834

 

Reiman, A. (2009). Cannabis as a substitute for alcohol and other drugs. Harm Reduction Journal, 6(1), 35. https://doi.org/10.1186/1477-7517-6-35

 

Robb, C. A., Moody, B., & Abdel-Ghany, M. (2012). College student persistence to degree: The burden of debt. Journal of College Student Retention: Research, Theory & Practice, 13(4), 431-456. https://doi.org/10.2190/CS.13.4.b

 

Rubinstein, M. L., Rait, M. A., & Prochaska, J. J. (2014). Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers. Drug and Alcohol Dependence, 141, 159-162. https://doi.org/10.1016/j.drugalcdep.2014.05.015

 

Schmidt, L., Weisner, C., & Wiley J. (1998). Substance abuse and the course of welfare dependency. American Journal of Public Health (1971), 88(11), 1616–22. https://doi.org/10.2105/AJPH.88.11.1616

 

Semple, D. M., McIntosh, A. M., & Lawrie, S. M. (2005). Cannabis as a risk factor for psychosis: Systematic review. Sage Publicationshttps://doi.org/10.1177/0269881105049040

 

Smith, D. E. (1968). Acute and chronic toxicity of marijuana. Journal of Psychedelic Drugs, 2(1), 37-48. https://doi.org/10.1080/02791072.1968.10524399

 

Studies from washington university yield new information about marijuana/cannabis (A large-scale genome-wide association study meta-analysis of cannabis use disorder). (2021). Psychology & Psychiatry Journal, 503https://link.gale.com/apps/doc/A646718700/AONE?u=humber&sid=summon&xid=bc33d18f

 

Subbaraman, M. S. (2014). Can cannabis be considered a substitute medication for alcohol? Alcohol and Alcoholism (Oxford), 49(3), 292-298. https://doi.org/10.1093/alcalc/agt182

 

Suresh, K. (2011). An overview of randomization techniques: An unbiased assessment of outcome in clinical research. Journal of Human Reproductive Sciences, 4(1), 8-11. https://doi.org/10.4103/0974-1208.82352

 

Szoke, A., Galliot, A., Richard, J., Ferchiou, A., Baudin, G., Leboyer, M., & Schürhoff, F. (2014). Association between cannabis use and schizotypal dimensions –A meta-analysis of cross-sectional studies. Psychiatry Research, 219(1), 58-66. https://doi.org/10.1016/j.psychres.2014.05.008

 

Timmins, B. (2017). Cannabis users are more successful and satisfied, finds new study. Independent. https://www.independent.co.uk/life-style/cannabis-users-success-satisfied-marijuana-weed-study-well-adjusted-rich-a7792991.html

 

Voelkl, K. E., & Frone, M. R. (2000). Predictors of substance use at school among high school students. Journal of Educational Psychology, 92(3), 583-592. https://doi.org/10.1037//0022-0663.92.3.583

 

Watkins. M., (2020). Marijuana (Weed, cannabis) Overdose symptoms, signs & treatment. American Addictions Centers. https://drugabuse.com/drugs/marijuana/overdose/

 

Wiesbeck, G. A., Schuckit, M. A., Kalmijn, J. A., Tipp, J. E., Bucholz, K. K., & Smith, T. L. (1996). An evaluation of the history of a marijuana withdrawal syndrome in a large population. Addiction (Abingdon, England), 91(10), 1469-1478. https://pubmed.ncbi.nlm.nih.gov/8917915/

 

World Health Organization. (2016). The health and social effects of nonmedical cannabis use. https://apps.who.int/iris/handle/10665/251056

 

World Health Organization (WHO). (2016). International statistical classification of diseases and related health problems - Tenth revision (ICD-10). https://apps.who.int/iris/bitstream/handle/10665/246208/9789241549165-V3-eng.pdf?sequence=3&isAllowed=y

 

Adlaf, E. M., Hamilton, H. A., Wu, F., & Noh, S. (2009). Adolescent stigma towards drug addiction: Effects of age and drug use behaviour. Addictive Behaviors, 34(4), 360–364. https://doi.org/10.1016/j.addbeh.2008.11.012

 

Botvin, G. J., & Griffin, K. W. (2007). School-based programmes to prevent alcohol, tobacco and other drug use. International Review of Psychiatry (Abingdon, England), 19(6), 607–615. https://doi.org/10.1080/09540260701797753

 

Bränström, R., Sjöström, E., & Andréasson, S. (2007). Individual, group and community risk and protective factors for alcohol and drug use among swedish adolescents. European Journal of Public Health, 18(1), 12–18. https://doi.org/10.1093/eurpub/ckm038

 

Chaloupka, F. J., Grossman, M., & Saffer, H. (2002). The effects of price on alcohol consumption and alcohol-related problems. Alcohol Research & Health: The Journal of the National Institute on Alcohol Abuse and Alcoholism, 26(1), 22–34. https://pubmed.ncbi.nlm.nih.gov/12154648/

 

Chaloupka, F. J., & Wechsler, H. (1996). Binge drinking in college: The impact of price, availability, and alcohol control policies. Contemporary Economic Policy, 14(4), 112–124. https://doi.org/10.1111/j.1465-7287.1996.tb00638.x

 

Farrelly, M. C., Bray, J. W., Zarkin, G. A., & Wendling, B. W. (2001). The joint demand for cigarettes and marijuana: Evidence from the national household surveys on drug abuse. Journal of Health Economics, 20(1), 51–68. https://doi.org/10.1016/S0167-6296(00)00067-9

 

Grossman, M. (2005). Individual behaviours and substance use: The role of price. In B. lindgren & M. grossman (Eds.), Substance Use: Individual Behaviour, Social Interactions, Markets and Politics. https://doi.org/10.1016/S0731-2199(05)16002-6

 

Grossman, M., Chaloupka, F. J., Saffer, H., & Laixuthai, A. (1994). Effects of alcohol price policy on youth: A summary of economic research. Journal of Research on Adolescence (Lawrence Erlbaum), 4(2), 347–364. https://doi.org/10.3386/w4385

 

Hathaway, A. D., Comeau, N. C., & Erickson, P. G. (2011). Cannabis normalization and stigma: Contemporary practices of moral regulation. Criminology & Criminal Justice, 11(5), 451–469. https://doi.org/10.1177/1748895811415345

 

Kuo, M., Wechsler, H., Greenberg, P., & Lee, H. (2003). The marketing of alcohol to college students: The role of low prices and special promotions. American Journal of Preventive Medicine, 25(3), 204–211. https://doi.org/10.1016/s0749-3797(03)00200-9

 

Leverett, M., Ashe, M., Gerard, S., Jenson, J., & Woollery, T. (2002). Tobacco use: The impact of prices. The Journal of Law, Medicine & Ethics, 30(3), 88–95. https://pubmed.ncbi.nlm.nih.gov/12508509/

 

Parker, H., & Egginton, R. (2002). Adolescent recreational alcohol and drugs careers gone wrong: developing a strategy for reducing risks and harms. International Journal of Drug Policy, 13(5), 419–432. https://doi.org/https://doi.org/10.1016/S0955-3959(02)00154-8

 

Rhodes, W., Johnston, P., Han, S., McMullen, Q., & Hozik, L. (2000). Illicit drugs: Price elasticity of demand and supply. Abt Associates. 

 

Stockwell, T., Zhao, J., Giesbrecht, N., Macdonald, S., Thomas, G., & Wettlaufer, A. (2012). The raising of minimum alcohol prices in saskatchewan, canada: Impacts on consumptionand implications for public health. American Journal of Public Health, 102(12), e103–e110. https://doi.org/10.2105/AJPH.2012.301094

 

van Ours, J. C., & Williams, J. (2007). Cannabis prices and dynamics of cannabis use. Journal of Health Economics, 26(3), 578–596. https://doi.org/10.1016/j.jhealeco.2006.10.001

 

Xu, X., & Chaloupka, F. J. (2011). The effects of prices on alcohol use and its consequences. Alcohol Research & Health : The Journal of the National Institute on Alcohol Abuse and Alcoholism, 34(2), 236–245. https://pubmed.ncbi.nlm.nih.gov/22330223

 

Alcohol and Gaming Commission of Ontario. (n.d.). First allocation of stores - Expression of interest lottery. https://www.agco.ca/cannabis/cannabis-retail-lottery 

 

Cannabis Act (S.C. 2018, c. 16). https://laws-lois.justice.gc.ca/eng/acts/c-24.5/ 

 

Cannabis Regulations (SOR/2018-144). https://laws-lois.justice.gc.ca/eng/Regulations/SOR-2018-144/index.html  

 

CDPE. (2020, October 14). Canada’s legal cannabis industry lacks diversity, a new policy brief by the centre on drug policy evaluation and the university of toronto finds. https://cdpe.org/canadas-legal-cannabis-industry-lacks-diversity/#:~:text=The%20new%20policy%20brief%20found,%2C%20and%201%25%20Latinx). 

 

Government of Canada. (2016, December 13). A framework for the legalization and regulation of cannabis in canada. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/laws-regulations/task-force-cannabis-legalization-regulation/framework-legalization-regulation-cannabis-in-canada.html#a2.2 

 

Government of Canada. (2019). Final regulations: Edible cannabis, cannabis extracts, cannabis topicals. https://www.canada.ca/content/dam/hc-sc/documents/services/drugs-medication/cannabis/resources/final-regulations-edible-cannabis-extracts-topical-eng.pdf 

 

Government of Canada. (2019, December 23). Summary of results for the canadian student tobacco, alcohol and drugs survey 2018-19. https://www.canada.ca/en/health-canada/services/canadian-student-tobacco-alcohol-drugs-survey/2018-2019-summary.html 

 

Government of Canada. (2019, June 14). Directory of nutrition facts table formats for edible cannabis. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/laws-regulations/regulations-support-cannabis-act/directory-nutrition-facts-table-formats-edible.html 

 

Government of Canada. (2019, November 5). The cannabis act and cannabis regulations: Promotion prohibitions. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/laws-regulations/promotion-prohibitions.html 

 

Government of Canada. (2020). Canadian cannabis survey 2020: Summaryhttps://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/research-data/canadian-cannabis-survey-2020-summary.html#a4

 

Government of Canada. (2021). Authorized cannabis retailers in the provinces and territories. https://www.canada.ca/en/health-canada/services/drugs-medication/cannabis/laws-regulations/provinces-territories.html

 

Government of Canada. (2021, February 3). Cannabis legalization and regulation. https://www.justice.gc.ca/eng/cj-jp/cannabis/ 

 

Health Canada. (2018). Cannabis public education activities. Government of Canada. https://www.canada.ca/en/health-canada/news/2018/06/cannabis-public-education-activities.html

 

Health Canada, Cannabis Legalization and Regulation Branch. (2018). Promotion prohibitions under the cannabis act. https://commb.ca/wp-content/uploads/2018/09/25152254/Cannabis_Act_Promotion_Prohibitions_EN.pdf 

 

Lisdahl, K. M., Gilbart, E. R., Wright, N. E., & Shollenbarger, S. (2013). Dare to delay? The impacts of adolescent alcohol and marijuana use onset on cognition, brain structure, and function. Frontiers in psychiatry, 4, 53. https://doi.org/10.3389/fpsyt.2013.00053

 

Pfeffer, A. (2019, November 13). Pot producers implore ontario to open more stores. CBC News. https://www.cbc.ca/news/canada/ottawa/pot-producers-implore-ontario-open-stores-1.5357101

 

Rotermann, M. (2020, February 19). What has changed since cannabis was legalized? Statistics Canada. https://www150.statcan.gc.ca/n1/pub/82-003-x/2020002/article/00002-eng.htm 

 

Solowij, N., Jones, K. A., Rozman, M. E., Davis, S. M., Ciarrochi, J., Heaven, P. C., Lubman, D. I., & Yücel, M. (2011). Verbal learning and memory in adolescent cannabis users, alcohol users and non-users. Psychopharmacology, 216(1), 131–144.https://doi.org/10.1007/s00213-011-2203-x 

 

Tobacco and Vaping Products Act, S.C. 1997, c. 13. https://laws-lois.justice.gc.ca/eng/acts/t-11.5/

 

Abelman, D. D. (2017). Mitigating risks of students use of study drugs through understanding motivations for use & applying harm reduction theory: A literature review. Harm Reduction Journal, 14(1), 68. https://doi.org/10.1186/s12954-017-0194-6 

 

Ali, S., Mouton, C. P., Jabeen, S., Ofoemezie, E. K., Bailey, R. K., Shahid, M., & Zeng, Q. (2011). Early detection of illicit drug use in teenagers. Innovations in Clinical Neuroscience, 8(12), 24–28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257983/

 

Arria, A. M., & DuPont, R. L. (2010). Nonmedical prescription stimulant use among college students: Why we need to do something and what we need to do. Journal of Addictive Diseases, 29(4), 417-426. https://doi.org/10.1080/10550887.2010.509273 

 

Canadian Centre on Substance Abuse. (n.d.). Canadian centre on substance abuse. https://www.ccsa.ca/

 

Canadian Centre on Substance Abuse. (2014). The canadian standards for youth substance abuse prevention: An overview. https://www.ccsa.ca/sites/default/files/2019-05/2014-CCSA-Canadian-Standards-Youth-Substance-Abuse-Prevention-Overview-en.pdf

 

Department of Justice. (2018, September 26). National anti-drug strategy evaluationhttps://www.justice.gc.ca/eng/rp-pr/cp-pm/eval/rep-rap/12/nas-sna/p4.html

 

Fischer, B. (2005). Substance abuse in canada: Current challenges and choices. Canadian Centre on Substance Abuse, 11–12. https://www.ccsa.ca/sites/default/files/2019-04/ccsa-004032-2005.pdf 

 

Gaetz, S. (2014). Harm reduction. Homeless Hub. https://www.homelesshub.ca/solutions/supports/harm-reduction 

 

Mitra, S., & Globerman, J. (2016). Engaging law enforcement in harm reduction programs for people who inject drugs. Ontario HIV Treatment Network. http://www.ohtn.on.ca/wp-content/uploads/2016/08/rr109_law-enforcement-harm-reduction.pdf 

 

Public Health England. (2015). The international evidence on the prevention of drug and alcohol use. https://healtheducationresources.unesco.org/library/documents/international-evidence-prevention-drug-and-alcohol-use-summary-and-examples

 

Shaw, A., Egan, J., & Gillespie, M. (2007). Drugs and poverty: A literature review. Scottish Drugs Forum. http://www.dldocs.stir.ac.uk/documents/drugpovertylitrev.pdf 

 

Spooner, C., & Hetherington, K. (2004). Social Determinants of Drug Use. National Drug and Alcohol Research Centre. https://ndarc.med.unsw.edu.au/sites/default/files/ndarc/resources/TR.228.pdf

 

United Nations International Drug Control Programme (UNDCP). (1995). The social impact of drug abuse. https://www.unodc.org/pdf/technical_series_1995-03-01_1.pdf

 

Vancouver Police Department. (2006). Vancouver police department drug policy. https://vancouver.ca/police/assets/pdf/reports-policies/vpd-policy-drug.pdf

 

Warren, F. (2016, December). 'What works' in drug education and prevention? Scottish Government. http://www.edex.es/wp-content/uploads/What-works-in-prevention.pdf

 

Becvar, D. S. (2007). Families that flourish: Facilitating resilience in clinical practice. WW Norton & Company. 

 

Birtchnell, J. (1975). Psychiatric breakdown following recent parent death. British Journal of Medical Psychology, 48(4), 379–390. https://doi.org/10.1111/j.2044-8341.1975.tb02346.x

 

Bonanno, G. A., Wortman, C. B., Lehman, D. R., Tweed, R. G., Haring, M., Sonnega, J., Carr, D., & Nesse, R. M. (2002). Resilience to loss and chronic grief: A prospective study from preloss to 18-months postloss. Journal of Personality and Social Psychology, 83(5), 1150-1164. https://doi.org/10.1037//0022-3514.83.5.1150

 

Brent, D. A., Perper, J. A., Moritz, G., Liotus, L., Schweers, J., & Canobbio, R. (1994). Major depression or uncomplicated bereavement? A follow-up of youth exposed to suicide. Journal of the American Academy of Child & Adolescent Psychiatry, 33(2), 231–239. https://doi.org/10.1097/00004583-199402000-00012

 

Brewer, N. T., Weinstein, N. D., Cuite, C. L., & Herrington, J. E. (2004). Risk perceptions and their relation to risk behavior. Annals of Behavioral Medicine, 27(2), 125–130. https://doi.org/10.1207/s15324796abm2702_7

 

Burton, A. M., Haley, W. E., & Small, B. J. (2006). Bereavement after caregiving or unexpected death: Effects on elderly spouses. Aging and Mental Health, 10(3), 319–326. https://doi.org/10.1080/13607860500410045

 

Bush, J., Phillimore, P., Pless-Mulloli, T., & Thompson, C. (2005). Carcass disposal and siting controversy: Risk, dialogue and confrontation in the 2001 foot-and-mouth outbreak. Local Environment, 10(6), 649–664. https://doi.org/10.1080/13549830500321907

 

Carey, M. P., Braaten, L. S., Jaworski, B. C., Durant, L. E., & Forsyth, A. D. (1999). Hiv and aids relative to other health, social, and relationship concerns among low-income urban women: A brief report. Journal of Women’s Health and Gender-Based Medicine, 8(5), 657–661. https://doi.org/10.1089/jwh.1.1999.8.657

 

Carr, D. (2004). Gender, preloss marital dependence, and older adults’ adjustment to widowhood. Journal of Marriage and Family, 66(1), 220–235. https://doi.org/10.1111/j.0022-2445.2004.00016.x

 

Conner, M., & Norman, P. (2005). Predicting health behaviour. UK: McGraw-Hill Education. 

 

De Cock, K. M., Jaffe, H. W., & Curran, J. W. (2011). Reflections on 30 years of aids. Emerging Infectious Diseases, 17(6), 1044-1048. https://doi.org/10.3201/eid/1706.100184

 

Drew, S. (2007). Having cancer changed my life, and changed my life forever’: Survival, illness legacy and service provision following cancer in childhood. Chronic Illness, 3(4), 278–295. https://doi.org/10.1177/1742395307085236

 

Egnew, T. R. (2005). The meaning of healing: Transcending suffering. The Annals of Family Medicine, 3(3), 255–262. https://doi.org/10.1370/afm.313

 

Elwert, F., & Christakis, N. A. (2008). The effect of widowhood on mortality by the causes of death of both spouses. American Journal of Public Health, 98(11), 2092–2098. https://doi.org/10.2105/AJPH.2007.114348

 

Fauci, A. S., & Morens, D. M. (2012). The perpetual challenge of infectious diseases. New England Journal of Medicine, 366(5), 454–461. https://doi.org/10.1056/NEJMra1108296

 

Folkman, S., & Greer, S. (2000). Promoting psychological well-being in the face of serious illness: When theory, research and practice inform each other. Psycho-Oncology: Journal of the Psychological, Social and Behavioural Dimensions of Cancer, 9(1), 11–19. https://doi.org/10.1002/(sici)1099-1611(200001/02)9:1<11::aid-pon424>3.0.co;2-z

 

Gallacher, J., Bronstering, K., Palmer, S., Fone, D., & Lyons, R. (2007). Symptomatology attributable to psychological exposure to a chemical incident: A natural experiment. Journal of Epidemiology & Community Health, 61(6), 506–512. https://doi.org/10.1136/jech.2006.046987

 

Greene, G., Turley, R., Mann, M., Amlôt, R., Page, L., & Palmer, S. (2014). Differing community responses to similar public health threats: A cross-disciplinary systematic literature review. Science of the Total Environment, 470, 759–767. https://doi.org/10.1016/j.scitotenv.2013.10.031

 

Greyson, B., & Khanna, S. (2014). Spiritual transformation after near-death experiences. Spirituality in Clinical Practice, 1(1), 43-45. https://doi.org/10.1037/scp0000010

 

Guidotti, T. L., & Jacobs, P. (1993). The implications of an epidemiological mistake: A community’s response to a perceived excess cancer risk. American Journal of Public Health, 83(2), 233–239. https://doi.org/10.2105/AJPH.83.2.233

 

Horowitz, M. J., Krupnick, J., Kaltreider, N., Wilner, N., Leong, A., & Marmar, C. (1981). Initial psychological response to parental death. Archives of General Psychiatry, 38(3), 316–323. https://doi.org/10.1001/archpsyc.1981.01780280084010

 

Hughes, M. E., & Waite, L. J. (2009). Marital biography and health at mid-life. Journal of Health and Social Behavior, 50(3), 344–358. https://doi.org/10.1177/002214650905000307

 

Kilpatrick, A. M., & Randolph, S. E. (2012). Drivers, dynamics, and control of emerging vector-borne zoonotic diseases. The Lancet, 380(9857), 1946–1955. https://doi.org/10.1016/S0140-6736(12)61151-9

 

Lau, J. T., Yang, X., Pang, E., Tsui, H. Y., Wong, E., & Wing, Y. K. (2005). Sars-related perceptions in hong kong. Emerging Infectious Diseases, 11(3), 417-424. https://pubmed.ncbi.nlm.nih.gov/15757557/

 

Lee, G. R., & DeMaris, A. (2007). Widowhood, gender, and depression: A longitudinal analysis. Research on Aging, 29(1), 56–72. https://doi.org/10.1177/0164027506294098

 

Leung, G. M., Quah, S., Ho, L. M., Ho, S. Y., Hedley, A. J., Lee, H. P., & Lam, T. H. (2004). A tale of two cities: Community psychobehavioral surveillance and related impact on outbreak control in hong kong and singapore during the severe acute respiratory syndrome epidemic. Infection Control & Hospital Epidemiology, 25(12), 1033–1041. https://doi.org/10.1086/502340

 

Liu, W.-M., Forbat, L., & Anderson, K. (2019). Correction: Death of a close friend: Short and long-term impacts on physical, psychological and social well-being. PloS One, 14(5), e0218026. https://doi.org/10.1371/journal.pone.0218026

 

Lucas, R. E., Clark, A. E., Georgellis, Y., & Diener, E. (2003). Reexamining adaptation and the set point model of happiness: reactions to changes in marital status. Journal of Personality and Social Psychology, 84(3), 527-539. https://doi.org/10.1037//0022-3514.84.3.527

 

Melhem, N. M., Porta, G., Shamseddeen, W., Payne, M. W., & Brent, D. A. (2011). Grief in children and adolescents bereaved by sudden parental death. Archives of General Psychiatry, 68(9), 911–919. https://doi.org/10.1001/archgenpsychiatry.2011.101

 

Morens, D. M., & Fauci, A. S. (2013). Emerging infectious diseases: threats to human health and global stability. PLoS Pathogens, 9(7), e1003467. https://doi.org/10.1371/journal.ppat.1003467

 

Moskowitz, J. T., Hult, J. R., Bussolari, C., & Acree, M. (2009). What works in coping with hiv? A meta-analysis with implications for coping with serious illness. Psychological Bulletin135(1), 121-141. https://doi.org/10.1037/a0014210

 

Ong, A. D., Fuller-Rowell, T. E., & Bonanno, G. A. (2010). Prospective predictors of positive emotions following spousal loss. Psychology and Aging, 25(3), 653-660. https://doi.org/10.1037/a0018870

 

Perrins, J., King, N., & Collings, J. (1998). Assessment of long-term psychological well-being following intensive care. Intensive and Critical Care Nursing, 14(3), 108–116. https://doi.org/10.1016/s0964-3397(98)80351-0

 

Rowan, K. M. (1992). Outcome comparisons of intensive care units in Great Britain and Ireland using the APACHE II method. Oxford: University of Oxford. 

 

Rubin, G. J., Amlôt, R., Page, L., & Wessely, S. (2009). Public perceptions, anxiety, and behaviour change in relation to the swine flu outbreak: Cross sectional telephone survey. BMJ: British Medical Journal, 339(7713), 156. https://doi.org/10.1136/bmj.b2651

 

Rubin, G. J., Finn, Y., Potts, H. W. W., & Michie, S. (2015). Who is sceptical about emerging public health threats? Results from 39 national surveys in the united kingdom. Public Health, 129(12), 1553–1562. https://doi.org/10.1016/j.puhe.2015.09.004

 

Rubin, G. J., Potts, H. W. W., & Michie, S. (2010). The impact of communications about swine flu (influenza a h1n1v) on public responses to the outbreak: Results from 36 national telephone surveys in the uk. Health Technology Assessment, 14(34), 183–266. https://doi.org/10.3310/hta14340-03

 

Schulz, R., & Beach, S. R. (1999). Caregiving as a risk factor for mortality: The caregiver health effects study. JAMA, 282(23), 2215–2219. https://doi.org/10.1001/jama.282.23.2215

 

Setbon, M., & Raude, J. (2009). Population response to the risk of vector-borne diseases: Lessons learned from socio-behavioural research during large-scale outbreaks. Emerging Health Threats Journal, 2, e6. https://pubmed.ncbi.nlm.nih.gov/22460287/

 

Smith, R. D. (2006). Responding to global infectious disease outbreaks: Lessons from sars on the role of risk perception, communication and management. Social Science & Medicine (1982), 63(12), 3113–3123. https://doi.org/10.1016/j.socscimed.2006.08.004

 

Stroebe, M., Schut, H., & Stroebe, W. (2007). Health outcomes of bereavement. The Lancet (British Edition), 370(9603), 1960–1973. https://doi.org/10.1016/S0140-6736(07)61816-9

 

Stroebe, W., & Stroebe, M. S. (1987). Bereavement and health: The psychological and physical consequences of partner loss. Cambridge University Press. 

 

Sutton, S. (1987). Social-psychological approaches to understanding addictive behaviours: Attitude-behaviour and decision-making models. British Journal of Addiction, 82(4), 355–370. https://doi.org/10.1111/j.1360-0443.1987.tb01492.x

 

Taylor, S. (2020). Transformation through loss and grief: A study of personal transformation following bereavement. The Humanistic Psychologist, 49(3), 381-399. https://doi.org/10.1037/hum0000172

 

Tedlie Moskowitz, J., & Wrubel, J. (2005). Coping with hiv as a chronic illness: A longitudinal analysis of illness appraisals. Psychology & Health, 20(4), 509–531. https://doi.org/10.1080/08870440412331337075

 

Tyson, J. (2013). Turning a tragedy into a tribute: A literature review of creating meaning after loss of a loved one. Illness, Crisis & Loss, 21(4), 325–340. https://doi.org/10.2190/IL.21.4.e

 

Umberson, D., & Chen, M. D. (1994). Effects of a parent’s death on adult children: Relationship salience and reaction to loss. American Sociological Review, 59(1), 152–168. https://doi.org/10.2307/2096138

 

Umberson, D., Wortman, C. B., & Kessler, R. C. (1992). Widowhood and depression:Explaining long-term gender differences in vulnerability. Journal of Health and Social Behavior, 33(1), 10–24. https://doi.org/10.2307/2136854

 

van Eys, J. (1988). Is all well with the young man, Absalom. Springfield, IL: Charles C. Thomas

 

Weinstein, N. D. (1993). Testing four competing theories of health-protective behavior. Health Psychology, 12(4), 324-333. https://doi.org/10.1037/0278-6133.12.4.324

 

Williams, K. (2003). Has the future of marriage arrived? A contemporary examination of gender, marriage, and psychological well-being. Journal of Health and Social Behavior,44(4), 470-487. https://doi.org/10.2307/1519794

 

Wurm, S., Tomasik, M. J., & Tesch-Römer, C. (2008). Serious health events and their impact on changes in subjective health and life satisfaction: The role of age and a positive view on ageing. European Journal of Ageing, 5(2), 117–127. https://doi.org/10.1007/s10433-008-0077-5

 

Zisook, S., Chentsova-Dutton, Y., & Shuchter, S. R. (1998). Ptsd following bereavement. Annals of Clinical Psychiatry, 10(4), 157–163. https://doi.org/10.1023/a:1022342028750